Amyloidosis is a disease characterized by the extracellular deposition of insoluble fibrillar proteins in the tissues and organs including the heart [1,2]. There are 3 major subtypes of cardiac amyloid: light chain amyloidosis, hereditary transthyretin amyloidosis and wild-type transthyretin amyloidosis, also called senile systemic amyloidosis (SSA). SSA is almost exclusively a disease of the elderly caused by the deposition of wild-type transthyretin fibrils predominantly in the myocardium leading to progressive heart failure, arrhythmia and conduction blocks [3]. Post mortem studies have shown that the finding of amyloid depositis (wild-type transthyretin) is not uncommon [4], however the actual prevalence is not known.
The natural history of SSA is not well documented, most likely due to the fact that it’s rarely diagnosed before death [5]. Typically it presents with symptoms and signs of biventricular cardiac failure
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This, however, is difficult in the patient population affected, as an endomyocardial biopsy is an invasive procedure that patients are not keen to undergo. Cardiac MRI is a useful investigation when cardiac amyloid is suspected but it is unable to differentiate between different amyloid types [13]. Tc-DPD scintigraphy is a recent addition to the workup of the condition and has been shown to be a specific imaging tool for transthyretin cardiac amyloid [12].
The prognosis of patients with SSA is much better than other subtypes of cardiac amyloid [5,9]; a previous study found that for patients with SSA and heart failure the median survival was 5 years [9] compared with 6 months after the onset of heart failure for AL amyloidosis [14]. Currently no specific disease modifying therapies are available, although promising new agents are being investigated in a number of clinical
Robert is a ninety-year-old man, who has been experiencing progressive and worsening heart failure. He has a long cardiac history and has been under the care of a cardiologist for the past 30 years. His medical history includes, hypertension, osteoarthritis, dyslipidemia and heart disease. Robert lives in a senior condominium community with his wife Janet.
Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior. It is the most common form of Dementia which is a general term for a decline in mental ability severe enough to interfere with daily life. Alzheimer’s accounts for 60-80% of dementia cases. Based on 2018 Alzheimer’s Association statistics, there are more than 5 million Americans living with Alzheimer’s over the age of 65 (Alzheimer’s Association, 2018). Many scientists state the death rate for heart disease has declined by 11% while death by Alzheimer’s has raised by 123% (Alzheimer’s Association, 2018). It is considered to be the 6th leading cause of death in the United States (Alzheimer’s Association, 2018). Alzheimer’s disease(AD) is an abnormal aging
Alzheimer’s disease is a chronic neurodegenerative disease that accounts for sixty to seventy percent of Dementia cases. It is characterized by the development of amyloid plaques and neurofibrillary tangles, the loss of connection between neurons in the brain and the death of nerve cells. There are two types of Alzheimer’s Early on-set Alzheimer’s which occur from the ages of thirty to sixty is very rare and makes up less than five percent of the cases of Alzheimer’s . The second type is Late on-set Alzheimer’s which is the most common type and it is found in those of ages sixty and up. The progression of Alzheimer’s is a lengthy progress from the time of diagnosis the average life expectancy is three to nine years. In the early stages people have difficulty with short term memory loss as the disease progresses symptoms include difficulties with language, disorientation, mood swings, loss of motivation, loss of self-care and behavioral issues. As Alzheimer’s progresses a person slowly withdraws from family life and society due to the jumbled state of their memory. On a physical level the body’s physical function slowly degenerates and eventually leads to death.
Alzheimer’s Disease is a disease of the future. With the growing aged population, this disease, which affects primarily the elderly, will become of increasing relevance to the medical profession. Also, the high frequency of Alzheimer’s, and the high cost in labor, money, and material of caring for its victims shall put considerable burden on the society as a whole. Here, however, these issues are not going to be debated. Instead the pathology of Alzheimer’s will be reviewed to the extent it is known today.
Alzheimer disorder is an major nervous condition that present in irreparable loss of neuron in the cortex and hippocampus of the brain. The recurrence of the disease is 7% of people above 65 years old and 40% of individual above 80 years old. Patients commonly have issues in decision making, remembrance, and judgment. Pathological lineaments are specified as loss of neuron, extracellular senile plaques include peptide β-amyloid. Diagnosis is established on neurological feedback to rule out other reasons by using autopsy. Dopamine as neurotransmitter has an important part in etiology of Alzheimer disease and it is reduced in this disease.[3]
The Simon-Ehrlich wager was all about this idea of Malthusian catastrophe (Regis, 1997). The idea is that because of population growth we are running out of resources and we will eventually exhaust them all and die out. Julian Simon the so call cornucopian doom slayer challenged the Malthusian believer Paul Ehrlich to a bet. Simon told Ehrlich that he could pick any-raw material and and any date in the future. If Simon was correct the eventually price of these resources would decrease or not change more then inflation and if Ehrlich was correct since we are running out of resources the price of these metal would increase. Ehrlich selected five assorted metal which included chromium, copper, nickel, tin and tungsten. In the prices rose Simon
Alzheimer's Disease is a condition that affects 50% of the population over the age of eighty five, which equals four million Americans each year. It is becoming an important and high-profile issue in today's society for everyone. There are rapid advancements being made in the fight against this disease now more than ever, and the purpose of this essay is to educate the public on the background as well as the new discoveries. There are many new drugs that are being tested and studied every day which slow down, and may even halt the progress of the disease.
Symptoms. Alzheimer’s disease is commonly known for the symptom of forgetfulness; however, this is not the only symptom of Alzheimer’s. There are a few common symptoms that are associated with Alzheimer’s which include memory lapses, disorientation, trouble with speaking and writing, difficulties with thinking and reasoning, struggling with decision-making and judgement, trouble planning and performing familiar tasks, and changes in personality and behavior that affect a person’s daily life. According to the Alzheimer’s Association in their article “What is Alzheimer’s?,” “The most common early symptom of Alzheimer's is difficulty remembering newly learned information because Alzheimer's changes typically begin in the part of the brain that
Alzheimer's disease is worse than almost any other in a certain way. At least when you get cancer or heart disease you don't forget the names of loved ones and friends. It's almost worse to have your life mentally slip away as it does with Alzheimer's even if you are still physically intact. A relationship has been discovered between high blood pressure and this awful disease and strangely, it has been found to be an inverse relationship.
When judges are spoken of as a group, they are referred to as the judiciary. There are many different levels of judges, but the basic function is the same at all levels: judges are there to adjudicate on disputes in a fair, unbiased way, applying the legal rules of England and Wales. There is no clear-cut division between civil and criminal judges, as many judges at the various levels are required to sit for both types of case. This in itself causes problem as, before their appointment, most judges will have specialised in one area of law. The head of the judiciary is the Lord Chief Justice. When considering judges the first point is that there is a marked difference between what are we called superior judges and inferior judges. Superior
It is estimated that between 4.5 and 5.4 million Americans are affected by Alzheimer’s Disease (AD) (Vanmeter. P. 376). AD is a progressive disease that causes problems with memory, thinking and behavior. Changes with Alzheimer’s Disease are degenerative and results in gross atrophy of the cerebral cortex. The disease destroys brain cells which causes two types of abnormalities; neurofibrillary tangles and amyloid plaques (orange book p. 212). Neurofibrillary tangles cause death of neurons, which contributes to the development of dementia. Amyloid plaque disrupts transmission of nerve impulses. It is not clear if the plaque causes AD or a by-product of the AD process causes it. (212 orange).
Alzheimer's disease is a progressive neurodegenerative disease that occurs when nerve cells in the brain die. It was first diagnosed in 1906 by the German doctor Alois Alzheimer. AD is now the most common and serious type of dementia. Approximately 2.5 million people over the age of 65 in the United States have this disease. It has been predicted that AD could triple over the next 50 years as increasing numbers of people live to older ages.
Alzheimer’s disease is a neurodegenerative brain process that develops slowly over time. It is also known as senile dementia. Alzheimer’s disease is most widely thought to be caused by an increase in the production or accumulation of a specific protein (beta-amyloid protein) that leads to nerve cell death. This disease is thought to be inherited, though it does not mean that because either parent has it that the child will automatically have it. There is also a correlation that persons with limited formal education – less than eight years – are at an increased risk for Alzheimer’s disease. The likelihood of developing Alzheimer’s disease doubles every 5.5 years from age 65 to 85. The onset of Alzheimer’s disease can occur as early as 45 years
One of the most common forms of dementia in US is Alzheimer’s disease with an estimated 5.3 million Americans with Alzheimer’s disease in 2015 and approximately 700,000 patients of age 65 and older to die of this disease. Alzheimer’s has thus become the sixth leading cause of death in the U.S. Currently, one of the top 10 causes of death in America, Alzheimer’s disease progression cannot be slowed, cured or prevented. However, various researchers have been working on methods to decrease the progression or cure the disease, primarily focusing on the potentially modifiable risk factors.
Alzheimer’s disease, a life threatening disease that attacks your brain tissues. Imagine being a high school student whose grandfather is suffering from Alzheimer's Disease; always on the lookout waiting for him to show up unpleasant doing random tasks in the night. Alzheimer's Disease is a leading cause of death in the United States. There are 500,000 deaths yearly, and research shows that in 2050, 100 million will be diagnosed worldwide with as many as 16 million in the states (Marsa).