Analysis Of Cushing 's Syndrome ( Cs )

1379 Words6 Pages
Cushing’s syndrome (CS) is a condition whereby there is an excessive amount of glucocorticoids circulating in the human body1. There are two categories of CS, the most common type is exogenous, which is caused by supraphysiological amounts of glucocorticoids from an external source1. The second type is the endogenous CS and is caused by the endogenous over secretion of glucocorticoids by the adrenal glands2. The incidence of any form of CS has been reported to affect between 2-3 million population per year3, with a higher incidence in women over men4-5. CS is uncommon in children but if it does occur, it commonly presents with growth retardation and weight gain after puberty5. When an individual suffers from CS it causes a continuous…show more content…
As shown in Table 1 Cushing’s Disease is the most common cause of CS. This disease most commonly develops due to an ACTH producing pituitary tumor9. The increase in ACTH production leads to an increased ACTH concentration in plasma causing bilateral adrenocortical hyperplasia and hypersecretion of cortisol from the adrenal cortex. Due to the feedback mechanism as shown in Figure 1 a chronic increase in cortisol leads to the suppression of CRH and ACTH secretion. The second major corticotropin-dependent cause of CS is called ectopic corticotropin syndrome (Table I) and is caused most commonly from a pulmonary carcinoma however can be from other tumors and carcinomas such as bronchial carcinoma. These carcinomas produce ACTH in an abnormal place, this increase in plasma ACTH causes bilateral adrenocortical hyperplasia and increased cortisol secretion, and once again high cortisol levels lead to a suppression of the HPA feedback loop9. This cause creates a more rapid and severe increased cortisol state. The third and final corticotropin-dependent cause is similar to the above mechanism however is simply due to an increased secretion of CRH instead, this can be from any nonhypothalamic tumor secreting CRH. This mechanism therefor stimulates hyperplasia of

More about Analysis Of Cushing 's Syndrome ( Cs )

Open Document