Eli Lilly & Co’s (LLY) upcoming Fall 2016 data for Alzheimer’s disease drug Solanezumab has many investors wondering what we can expect from the Phase III readout. More generally, LLY has reignited investor interest in the Alzheimer’s treatment landscape. This week we will examine the disease and market size, and provide a brief overview of five companies (LLY, BIIB, AXON, MRK, and AB) with Phase III AD drugs in development. Lastly, we will raise some questions (hopefully with your help) for a free AD expert interview hosted by Slingshot Insights. What is Alzheimer’s Disease? AD is the most common type of dementia and causes problems with memory, behavior, and thinking. Symptoms typically worsen over time and the disease is most prevalent in the elderly. There are currently around 5 million people in the United States with AD and the number increases annually in tandem with the aging population. Although there are currently no treatments for Alzheimer’s, the market for drugs treating symptoms of the disease (like memory loss) is around $3 billion. This market could grow significantly if a disease-modifying treatment entered the space. The AD Companies You Should Know Although there are an abundant number of Phase I and II trials for AD, the number declines rapidly by Phase III. Let’s overview Lilly(LLY), Biogen (BIIB), Axovant (AXON), Merck (MRK), and AB Sciences (AB) to better understand five companies with AD Phase III trials underway. LLY has been a hot
Alzheimer disease (AD) is the most common cause of dementia in the elderly, accounting for 65–70% of all cases (Jellinger, Janetzky, Attems, & Kienzl, 2008). The other dementias are of the Parkinson 's group, the fronto-temporal group and the vascular group. The total worldwide yearly costs for the treatment and care of patients suffering from dementia are estimated to be around 250 billion US dollars. The lifetime risk for AD between the ages of 65 and 100 is 33% for men and 45% for women with an annual increase of 1–2% in the seventh decade to almost 60% in the 10th decade with doubling every 5 years (Jellinger et al., 2008). AD is incurable, and thus represents a major public health problem. AD represents a challenge to humanity due to its relatively recent discovery, progressive nature of the illness, and complex diagnosis.
Alzheimer’s disease (AD), a form of degenerative, fatal dementia, is characterized by progressive cognitive decline. While AD is the most common form of dementia, its prevalence has only recently been recognized. When Alois Alzheimer first described the sequence of changes in 1907, physicians believed the disease to be an extremely rare, mid-life condition. It wasn’t until the 1970’s that the same types of changes were shown to occur in both late- and early-onset forms (Cavanaugh et.al. 2008). As such, almost all knowledge of AD has been learned within the past several decades, with new discoveries being reported almost daily. It is now estimated that Alzheimer’s accounts for as many as 60% of all dementias and affects more than 500,000
Phase 3 clinical studies - Intended to gather the additional information about effectiveness and safety that is needed to evaluate the overall benefit-risk relationship of the drug.
The disease called Alzheimer’s is the fourth leading cause of death in the United States (Weiner, 1987). It is estimated that the elderly population will double between now and 2030. During this period, the number of elderly will grow by an average of 2.8% annually (U.S. Census Bureau, 2001). By 2050, the number of people with Alzheimer’s is estimated to range from 11.3 million to 16 million (Alzheimer’s Association, 2005). These startling numbers should prompt an examination into one of the leading causes of death among this group of people. Understanding what Alzheimer’s is and the known causes of the disease are a good starting point. For those who have aging family members, knowing the risk factors and warning
In the United States there are approximately 5.4 million people living with Alzheimer’s. Every sixty-nine seconds a person is diagnosed. This is an ongoing issue, and unless something is done, sixteen million people will be affected by 2050 (Latest).
Alzheimer’s disease is a prominent brain disease that effects a massive amount of individuals in the United States. Alzheimer’s disease (AD) is the sixth leading cause of death in the United States, accounting for 60-80% of dementia cases, with no chance of being cured, prevented or decelerating over time (Alzheimer’s Association, 2014). AD is the most well-known form of dementia, causing complications in brain function in the areas of memory, thinking, and behavior (Alzheimer’s Association, 2014). In an effort to gain a deeper understanding of Alzheimer’s disease, researchers create new knowledge about the disease, which is then distributed to the public. The goal in this information disbursement is to find new and inventive ways to treat AD, prevent AD from progressing at such a rapid pace, and aid in the quality of life in those diagnosed with AD as well as caregivers and medical professionals providing treatment to individuals’ with AD.
Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.
Alzheimer’s disease (AD) is a progressive and fatal form of dementia, frequently seen in the elderly altering their cognition, thought process and behavior. AD is reported in about half of patients that have a dementia diagnosis; one study states that about 10.3% of the population over 65 years is affected by dementia with an increase to almost 50% over the age of 8 (Beattie, 2002). Alzheimer’s disease is not a normal part of the aging process in humans, but rather found in a group of diseases that affect the brain leading to a decline in mental and physical control. AD when diagnosed has a very slow and gradual course, initially affecting the individual’s short term memory (Beattie, 2002). Alzheimer’s disease is the 6th leading cause of death, affecting more than five million people in the United States and is also one of the most common forms of dementia. Dementia can be defined as a disorder of progressive cognitive impairment severe enough to affect daily functions of an individual’s life (Fillit, et al., 2002).
Alzheimer’s disease (AD) is a form of dementia that causes problems with memory, thinking, and behavior. AD typically involves the development of a progressive neuropsychiatric disorder that is characterized by gradual memory impairment, loss of acquired skills and emotional disturbances (Lee, Y. J., Han, S. B., Nam, S. Y., Oh, K. W., & Hong, J. T.). Every 67 seconds an individual in the United States develops AD. AD is the sixth leading cause of death in the United States. There are 5.3 million Americans diagnosed with AD (Latest Alzheimer's Facts and Figures). AD is one of the few degenerative diseases that cannot be prevented, stopped, or cured (Latest Alzheimer's Facts and Figures). Post-mortem examination of the brain of AD patients usually
Alzheimer’s disease is a progressive degenerative brain disease characterized by progressive memory loss, cognitive impairment, and changes in behaviors and personality which has no cure. It is the most common cause of dementia in older adults and is increasing in prevalence in the younger population (Gosar & Bottomley, 2013). Research has shown that there are more than 5 million people in the United States and over 35 million people in the world who suffer from the disease. The number of Alzheimer’s patients increases steadily as the baby boomers age. Researches predicted that the population with Alzheimer’s disease will be doubled by 2030 (Alzheimer’s Association, 2015; Alzheimer’s Disease International, 2013; Black et al., 2010; Mohamed,
Alzheimer’s disease is a degenerative brain disease. It is a form of dementia most common in older individuals, identifiable to scientists by the presence of amyloid plaques and tau tangles. Most individuals associate the disease with memory loss, unusual behavior and moods, and watching their loved ones fade away. While there are recognized genetic risk factors that may contribute to disease-onset, environmental and lifestyle factors also play a role in disease development. Five FDA approved medications are currently on the market to treat symptoms, but none are capable of halting or slowing progression of the disease, nor are they capable of treating underlying causes. Though there is currently no known cure, scientists are working to
Despite being known for over one hundred years the cause of Alzheimer’s disease (AD) is still not completely understood. This terminal disease affects about 800,000 people in the UK and is expected to greatly increase in number of cases in the coming years. AD has proven to be an elusive disease to understand; yet it is more important than ever to continue researching AD in attempt to find a cure for the many people and family members that this disease affects.
One of the most common forms of dementia in US is Alzheimer’s disease with an estimated 5.3 million Americans with Alzheimer’s disease in 2015 and approximately 700,000 patients of age 65 and older to die of this disease. Alzheimer’s has thus become the sixth leading cause of death in the U.S. Currently, one of the top 10 causes of death in America, Alzheimer’s disease progression cannot be slowed, cured or prevented. However, various researchers have been working on methods to decrease the progression or cure the disease, primarily focusing on the potentially modifiable risk factors.
Alzheimer's Disease is a condition that affects 50% of the population over the age of eighty five, which equals four million Americans each year. It is becoming an important and high-profile issue in today's society for everyone. There are rapid advancements being made in the fight against this disease now more than ever, and the purpose of this essay is to educate the public on the background as well as the new discoveries. There are many new drugs that are being tested and studied every day which slow down, and may even halt the progress of the disease.
Alzheimer’s disease, the most common form of dementia, is a significant, persistent, and progressive memory loss that is associated with cognitive impairment and alterations in personality. Currently, there is no effective treatment for Alzheimer’s disease, despite the significant amount of effort by researchers. The main challenge in developing