Analysis Of Exelon ( Rivastigmine Tartrate )

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Exelon (Rivastigmine Tartrate) is a hydrogen tartrate salt of Rivastigmine that acts as a reversible cholinesterase inhibitor. As a cholinesterase, it is administered in an increasing amount over a set period of time. Through the inactivation of butyrlcholinesterase and acetylcholinesterase, Exelon prevents the breakdown of the chemical acetylcholine which is thought to be important in memory, thinking, and reasoning. Due to these capabilities, it is frequently employed to combat the effects of dementia due to Alzheimer’s and Parkinson’s diseases where patients tend to have a lower concentration of acetylcholine. Rivastigmine is also under evaluation in clinical trials as a treatment for cocaine dependence. It can be employed both orally and as a transdermal patch. The patch is more popular due to fewer side effects. In addition, Exelon has a size of about 250Da per molecule; this is small relative to the benchmark of 500Da for transdermal transfer. Its small size combined with its lipophillic and hydrophilic nature makes it ideal for topical administration. Rivastigmine has a halflife of about 1.5 hours and when taken in a transdermal patch, it has a lag phase of between 0.5 and 1 hour. When taken orally, it has a bioavailability that is linear until about 3mg at 40%. It then follows a nonlinear pharmacokinetic model, as its bioavailability will increase with an increase in dosage; when administered via transdermal patch, approximately 50% of the active ingredient is
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