Analysis Of Huntington's Disease

Huntington’s Disease is a brain disorder affecting movement, cognition, and emotions (Schoenstadt). It is a genetic disorder generally affecting people in their middle 30s and 40s (Sheth). Worldwide, Huntington’s disease (affects between 3-7 per 100,000 people of European ancestry (Schoenstadt). In the United States alone, 1 in every 30,000 people has Huntington’s disease (Genetic Learning Center). Huntington’s Disease is a multi-faceted disease, with a complex inheritance pattern and a wide range of symptoms. There is also much research being done in the field of Huntington’s disease, because as of 2012, this disease is untreatable. THESIS.

Most people with Huntington's disease develop signs and symptoms in their 40s or 50s, but the onset of disease may be earlier or later in life. When disease onset begins before age 20, the condition is called juvenile Huntington's disease. Earlier onset often results in a somewhat different presentation of symptoms and faster disease progression.

Huntington's Disease is a genetic autosomal disorder which effects the brain. It affects about 1 in 20,000 individuals. The symptoms of the disease do not start to occur until after or around 40 years of age. With the onset of the disease the patient starts to gradually deteriorate intellectually, this deterioration also causes involuntary movements. Scientists have only recently found the section of the gene which causes Huntington's disease, and this is allowed them to devise pre-symptomatic tests. However, a cure for the disease is yet to be found.

Huntington’s disease destroys the organs that carry the functions of the central nervous system. Kalat (2013) states, “Huntington disease (also known as Huntington disease or Huntington’s Chorea) is a severe neurological disorder that strikes about 1 person in 10,000 in the United States” (A.B. Young, 1995, p. 258).Individual’s develop the symptoms in their middle age, but even if it is a rare disorders juveniles as well as children before the age of ten can develop the disease. Huntington’s disease is hereditary disease that is passed on from a parent. Huntington’s disease is of the lack of the chromosome 4, if one of the parents carries the gene, they can pass that gene to their

At present, there is no cure for the disease, but dynamic progress has been made as researchers explore this illness. HD is inherited as an autosomal dominant condition. In March 1993, scientists realized that HD is caused by a mutation in a gene located on chromosome 4. This gene has a unique genetic sequence for CAG (cytosine-adenine-guanine) and codes for the amino acid glutamine, a building block for the huntingtin pr otein. Normal individuals have this sequence duplicated from 11 to 40 times in their genetic coding without having symptoms of HD. However, individuals with the disease have from 40 up to 100 repeated CAG segments. Juvenile Huntington's Disease occurs wit h 60 or more repeats, linking the longer chains of CAG sequences to earlier and more aggressive onset of the disease.

Huntington’s disease is an autosomal, dominant inherited disorder caused by a polyglutamine expansion at the amino-terminal on the huntingtin protein. It causes a progressive degeneration of spiny nerve cells in the striatum and cortex of the brain, impairing a person’s functional and cognitive abilities. Polyglutamine repeats of 36 are found to be non-threating but sequences containing an additional two or three repeats are associated with Huntington’s disease.

At this stage, the individual is completely dependent for their care. A major concern during this time is choking. Also, involuntary movements can either be very severe or have stopped completely ("What Is Huntington's Disease," 2017). Although no longer able to speak, the individual is usually still able to understand language and even be able to recognize family and friends. Those with HD often die due to complications from the disease not actually the disease itself, such as choking and infection ("What Is Huntington's Disease," 2017).

Huntington’s disease is caused by a mutation in the gene for a protein called Huntingtin. The genetic mutation results in the building blocks of DNA (cytosine, adenine, and guanine) to be replicated many more times than in an average individual. As a result, Huntington’s disease breaks down brain cells, or neurons, specifically located in the primary motor cortex regions of the brain, but can effect other brain areas

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

Huntington's disease affects people in different ways. One member of a family may have more trouble with clumsiness while another may have emotional outbursts. Moreover, symptoms of Huntington's disease in the same individual change over time.

Huntington’s Disease is a genetic disorder characterized by the arrival of symptoms late in life, usually in the 30s or 40s. It is an autosomal dominant disorder, which includes nerve cells breaking down in the brain. There are both movement and cognitive symptoms related to this disease. Some movement symptoms are unintentional jolting, delayed eye movements, and a compromised manner of walking. Some cognitive symptoms are trouble organizing responsibilities, a deficiency of cognizance of one’s own actions and capabilities, and a difficulty in understanding fresh material. There are also psychiatric disorders associated with Huntington’s disease: depression, obsessive compulsion disorder, and mania. Huntington’s disease results from a mutation

Huntington’s Disease is a disorder in the brain that has an impact on the way people talk, think, and move. The disease kills off cells in the part of the brain that controls movements, emotions, and cognitive ability, which is called the basal ganglia. The brain cells of people with Huntington’s Disease build up lots of protein that eventually turn toxic, and cause the cells to die over time. People with this disease can lose up to 25% of their brain cells before they die!

Imagine caring for someone with constant jerky movements, and every word he or she attempted to say came out with a slur. Something as simple as speaking is an everyday struggle for an individual with Huntington’s disease. This is just a brief description of obstacles a person may experience with Huntington’s disease. Huntington’s disease is a genetic neurodegenerative disease that causes defects in a person’s cognitive thinking, movement, and physiological stability. (Ersoy 2007) This disease has said to affect one in ten thousand people in the United States, regardless of race, gender, or ethnic background. (Ersoy 2007) Males and females with this disease are affected by at least one of their parents, meaning

Huntington's Disease causes the progressive breakdown (Degeneration) of nerve cells in the brain. Huntington's disease has a big impact on a person's functional abilities and usually results in movement, thinking, and psychiatric disorders. When the disease develops before age 20, the condition is called juvenile Huntington's disease. An earlier emergence of the disease often results in a somewhat different set of indications and faster disease progression. Huntington’s Disease mostly causes movement, thinking, and psychiatric disorders with a wide spectrum of signs and symptoms. Some symptoms include Movement Disorders which can lead to involuntary jerking or writhing movements and difficulty with the physical production of speech or swallowing. Thinking Disorders which make you have a lack of awareness of one's own behaviors/abilities and slowness in processing thoughts or have trouble finding words. It also can make you have Psychiatric Disorders which can make you have a feeling of sadness or irritability, Fatigue, and loss of energy, and frequent thoughts of death, dying or suicide. Now for the causes of disease, Huntington's disease is caused by an inherited defect in a single gene. Huntington's disease is an autosomal dominant disorder, which means that a person needs only one copy of the defective gene to develop the disease. With the exception of genes on the sex chromosomes, A person inherits two copies of every gene, one copy from mom and one from dad. A parent with a defective gene could pass along the defective copy of the gene or the healthy copy. Each child in the family, Therefore, Has a 50 percent chance of inheriting the gene that causes the Genetic

The following paper will cover a description of Huntington’s disease and the symptoms that go along with it, how to test for Huntington’s disease, a case study, what gene is involved, the chances of