Angiogenesis: New Blood Fertilization

(p133-134, text). * Define metastasis. * Development of a secondary tumor in a location distant from the primary tumor. * Accomplished via lymphatic channels and circulation. * Trace the pathways for the hematologic and lymphatic spread of metastatic cancer cells. Evidence of disseminate disease presence in lymph that drain the tumor area, tumor cells lodge first in the initial lymph node that receives drainage from the tumor site, once in this lymph node cells may die b/c of the lack of a proper environment, remain dormant for unknown reasons, or grow in a discernible mass, If they survive and grow cancer cells, may spread from more distant lymph nodes to the thoracic duct, and the gain access to the blood vasculature, cancer cells may gain access to the blood vasculature from the initial node and more distant lymph nodes by way of tumor-associated blood vessels that may infiltrate the tumor mass. Sentinel

There are three main types of blood vessels: arteries, veins, and capillaries. Arteries are vessels that usually carry highly oxygenated blood away from the heart and to the rest of the body. (The pulmonary trunk and related arteries are exceptions, as they actually carry blood from the lungs toward the heart.) Because arteries must transport high volumes of blood being forcefully pumped out by the heart and must therefore withstand greater pressure, most have thick, muscular walls and are more flexible as well. Arterioles, smaller types of arteries with thinner walls, branch off of the arteries to carry blood to another type of vessel, called the capillary. Capillaries are the most abundant blood vessels in the body. Thinner and smaller than the other blood vessels, the role of capillaries is to exchange substances like water, gases, chemicals, nutrients, wastes, etc. with the tissues of the body. The third type of blood vessel is the vein. Although they are generally larger than the other blood vessels, veins tend to have thinner, less flexible walls, as they are not forced to deal with such high blood pressures. Venules (veins’ versions of arteries’ arterioles) connect the capillaries to the veins, which then transport blood back

I found the differences between arteries and veins are their functions they provide to the heart as well as their structure. Arteries transfers blood away from the heart into the periphery resulting in the pressure of the blood in the arteries being high. Where as, the veins transfer blood towards the heart. Arteries carry oxygenated blood distributing it in the periphery as the pulmonary artery moves deoxygenated blood into the lungs for purification. The wall of an artery consists of three layers machining it thicker than veins. The elasticity within the layers of the muscle allows arteries to handle great pressures of blood within it. The thickest layer is known as tunica media as the other two are recognized as tunica externa, and tunica interna. The vein obtains blood from the periphery and carries it towards the heart. Veins are known to carry deoxygenated blood and transfers it the heart for purification. The pulmonary vein is known to carry oxygenated blood. However, there are semilunar valves found within the vein that does not allow retrograde flow of blood in preventing blood to flow in the opposite direction. Veins are thinner when compared to arteries consisting of thin elastic muscle layers with one thick layer being the tunica adventitia. Arteries consist of: carrying oxygenated blood expect for the pulmonary artery; deeply found in the body; thick walled and

Breast Cancer is a type of cancer where in the breast cells growth are uncontrolled. To enhance our understanding of breast cancer, knowing how any cancer can develop is crucial. Cancer develops as a result of the alteration of the genes, or abnormal changes in the genes accountable for managing the growth of the cells and maintaining their health. In each nucleus, the genes operates as the “control room.” The cells in our bodies replace themselves through a process called cell growth in which the

Correspondingly, there are two pathways that transports blood to the brain called internal carotid artery and vertebral artery. The internal carotid artery has three layers call the tunica adventitia, tunica media, and tunica intima. Tunica intima is made up of smooth muscle cells and elastin. The basilar artery forms and it branches out to the posterior cerebral arteries. The posterior cerebral arteries form the internal carotid arteries and when they connect they make cerebral arterial circle ( circle of willis). The middle cerebral arteries branch out two separate arteries called the anterior cerebral arteries. Each of these arteries are the force that direct the blood flow to the brain. There are three tiny vascular systems that work together to profuse the deep brain. Which are the pial, subependymal, and lenticulostriate arteries. The small area of white matter that depends on blood flow is called the subcortical “shed water” area. The subcortical is more prone than other areas of the brain to have ischemia. The leading cause of ischemia is the fibrin builds up and this cause a narrowing of the lumen. Which does not allow the flow of red blood cells and deprives the white matter of tissue of oxygen. The tissue then losses density and produces white matter lesions. The neurons become demyelinated which leads to loss of cognitive ability.

Breast Cancer is made up of glands also known as lubes. In a women breast the small tubes (lobules) carry milk to the nipples (ducts) . Breast cancer begins in the cells that are in the in the ducts. It can also start in other cells of the breast tissues. There is a pathway in the breast called lymph. Lymph causes the cancer to spread throughout the breast. The vessels that carry clear fluid instead of blood connect lymph.

Discuss the different types of blood vessels. Include the different layers composing blood vessels (remember to include tissue types) in your discussion.

Arteries carry blood away from the heart and are the largest of the blood vessels. Arteries are the largest and most muscular because of their function. They carry oxygenated blood away from the heart and therefore has force placed on them as the heart contracts and pumps. Veins carry blood back to the heart and lungs to be oxygenated again. The walls of veins are thin, elastic, and the flow of blood through veins are much slower and rely on surrounding muscles to push blood back to the heart. (They also have valves to prevent the backflow of

Cancer or the big C as it is commonly referred to by laymen is a scary word for people to hear or discuss. The exact cause of cancer is unknown, but is believed to be caused by many elements, including diet, chemicals, tobacco, radiation, and mutations that occur in the human body, as well as defective cells and genes. Experts know that cancer requires oxygen and nutrients to grow more cancer cells. The paper will explore the concept of angiogenesis, what it is, and how it impacts cancer, along with exploring activators and inhibitors to stop the growth of cancer. Natural products will be reviewed to highlight any potential value in eliminating and reducing the risks of getting any type of cancer.

Coronary Artery Disease is when the major vessels supplying the heart with blood, oxygen, and nutrients become blocked, damaged, or diseased. These major vessels (arteries) can become damaged in several ways including but not limited to high blood pressure, inflammation, high cholesterol, high sugar levels, and smoking. Following the initial damage of these vessels can cause even more

disease in which abnormal cells divide without control and can invade tissues nearby. Cancer can also spread to other parts of the body through the blood and lymph systems. The National cancer Institute and the World Health Organization (WHO) report that in 2012, there were 14 million new cancer cases and 8.2 million cancer related deaths. The number of new cases is expected to rise by about 70% over the next two decades. WHO also reports that in 2012 the most common cause of cancer death was lung cancer with 1.59 million deaths. The two main types of lung cancer are Small cell lung cancer (SCLC) and Non-small cell lung cancer (NSCLC). NSCLC makes up about 85% to 90% of lung cancers. Treatments for NSCLC can include surgery, radiation therapy, chemotherapy, immunotherapy and targeted therapies. One example of targeted therapy is angiogenesis therapy. Angiogenesis is the formation of blood vessels. Tumors need a blood supply to grow beyond a certain size and will give off a chemical signals to stimulate angiogenesis. One method of preventing this is to find ways to block tumor angiogenesis. This can be done through angiogenesis therapy, which is also called antiangiogenic agents. Angiogenesis is unique in fighting cancer because it focuses on blood vessels rather than tumor cells. Because angiogenesis is unique, arguments can be made for and against this type of treatment. This goal of this paper is to provide pros and cons for angiogenesis therapy.

Blood vessels are the conduits leading to and from the heart transporting blood throughout the body (bluedoorlabs). The arteries carry blood away from the heart whereas the veins carry blood back to the heart. The capillaries allow exchange of ions, small molecules and fluids. The arteries and veins are composed of three layers known as the tunica intima, tunica media, and tunica externa. The tunica interna is a cell that lines with the blood vessels. The tunica media is the middle layer, it changes the diameter of the blood vessel, that process is known as vasomotion. Tunica externa is the outer layer, it consists of loose connective tissue.

The first main vessel that leaves the heart is the pulmonary artery and is the only artery that carries de-oxygenated blood and traveling through the lungs is then oxygenated and returned to the heart by the pulmonary vein and that is the only vein in the body to carry oxygenated blood. The now oxygenated blood leaves from the heart by the aorta and the splits to the carotid artery also known as the subclavian artery to the arms and the thoracic artery. The carotid artery leads to smaller arteries, arterioles and continuous capillaries around the arms and head and lead back to the heart first through the fenestrated capillaries, venule and medium sized veins and back to the largest vein that is called the jugular vein that is also known as

Meanwhile, the favored channels for grafting are autologous arteries or veins. Although the use of arteries, such as the internal

The arteries are thicker and more elastic because of the fast pumping of blood that leaves the heart to other organs to the body, as where the veins are small due to the low blood flow because of the slow movement from the capillaries to the veins not like the forceful pumping from the heart to the arteries to the rest of the body. The Oxygenated blood goes through the arteries except the pulmonary arteries. Then Deoxygenated blood goes through the veins except the pulmonary veins. The lumen of the artery is narrow, were as the lumen of the veins is wider. There are not valves in the arteries, were as the valves are present in veins. In the arteries, endothelial cells of tunica intima are more long then wider, and have more elastic membrane that is more developed. Then the Tunica media is more muscular, and the tunica extrema is not as developed. In veins, the endothelial cells of tunica intima are not as long and have more elastic membrane then being developed. The Tunica media is less muscular were the tunica extrema is more developed. Arteries are deep within and the veins are more superficial. Capillaries are microscopic vessels; they carry blood from the arterioles then go to the small veins or venules. The wall of the capillary made up of a