Animal Models Of Ibd : What Are The Main Ones And How Are They Relevant For Ibd?

2145 WordsApr 12, 20169 Pages
MED 571 Assignment #5 Animal Models of IBD: What are the main ones and how are they relevant for IBD? Introduction Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the intestine, including ulcerative colitis (UC) and Crohn’s disease (CD), which is caused by a combination of mucosal barrier disruption, immune system activation and dysbiosis of the intestinal microbiota. Greater than 66 animal models have been used to study IBD and can be classified into chemically-induced, cell transfer, mutant and genetically engineered models1. Each model induces IBD through specific mechanisms involving the immune system, physiological and pathological processes that lead to chronic intestinal inflammation. These experimental IBD models are carried out in a number of animals, including rats and mice. By studying the different types of experimental models of IBD, it is possible to analyze the various mechanisms behind the disease as well as develop therapeutic strategies in treating inflammatory bowel disease. Chemically Induced Models Dextran sulfate sodium (DSS) model Dextran sulfate sodium (DSS) is a synthetic sulfated polysaccharide1 composed of dextran and sulfated anydro-glucose2. It is administered orally in drinking water to induce acute intestinal injury3 such as bloody diarrhea, mucosal ulceration, intestinal inflammation, weight loss and shortening of colon. A study performed by Cooper et al.4 suggests that focal crypt loss is the earliest
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