Anti- diabetic and antioxidant effects of grapefruit, mango and strawberry juice in streptozotocin – induced diabetic rats
Safaa Moustapha Abd El Fatah Faid1 , , Eman Aly Sadeek FadlAlla 2, Ebtihal Yaqoob Khojah3
1 Home Economics Dept. Faculty of specific Education, Ain Shams University, Egypt
2 Biochemistry & Nutrition Dept. Women 's College, Ain Shams University, Egypt.
3 Food science and nutrition Dept. Designs and home economic college, Taif University
E-mail: dr_safaa2010@yahoo.com, dr_emansaddeek@yahoo.com, eykhojah@yahoo.com
ABSTRACT
The present investigation was undertaken to evaluate the physicochemical characteristics of mango, grapefruit and strawberry juice and identification of phenolic acids and flavonoids compounds using HPLC. Also the present study aimed to investigate the effects of mango, grapefruit and strawberry juice at a dose of 1ml/day (was taken orally) to streptozotocin - induced diabetic rats for four weeks on serum triglycerides (TAG), serum glucose, serum insulin, total lipid (TL), total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in diabetic rats compared with control negative rats and diabetic rats fed on different fruit juice.
The results showed that the mango was the highest amounted in protein, crude fiber, ash content and total carbohydrates (0.82, 0.72, 0.51 and 9.61 g/100g fresh weight) followed by strawberry (0.50, 0.35, 0.27 and 8.95 g/100g fresh weight) and also, grapefruit was 0.40, 0.25,
The concentration of glucose in Gatorade was analyzed with a calibration curve, and to insured the best fit was used all R2 were of 0.99 or better (Figure 1). The calibration curve created with data of samples 1 to 7, with glucose concentration that ranged from 0.1mM to 0.06mM (Table 1). The calibrated samples were made with known glucose and to attain the concentration of glucose, specific enzymes that react with ferrocyanide and glucose were used. The first reaction of glucose oxidase, O2 and glucose were bind to create beta D-glucolactone and hydrogen peroxide. The hydrogen peroxide with a 1:1 stoiquiometric ration to glucose is catalyzed by horseradish peroxidase to Ferrocyanide. (lab manual) The final product of the enzymes catalysis is
Compared to diabetic control rats, total antioxidant levels were significantly increased in GTE supplemented rats. Inversely, malondialdehyde levels and AT(1) receptor were significantly lower in the GTE supplemented diabetic group [77]. Catechin and its derivatives in green tea are shown to be therapeutically very effective.
In this study, one group of male rats were given water sweetened with HFCS in addition to their standard diet and another group of male rats received water sweetened with table sugar with their standard diet for a period of 6 months. The proportion of HFCS used in the study was half the amount of the sugar used. The study “monitored weight gain, body fat and triglyceride levels in rats”. The male rats that had HFCS in their diet gained about 48 percent more weight (characteristic of obesity). They also had substantial increases in abdominal fat and circulating triglycerides (i.e. a “fatty liver”). "In humans, these same characteristics are known risk factors for high blood pressure, coronary artery disease, cancer and
Beta- carotene is an organic compound categorized as a terpenoid (Gutiérrez, & Gonzalez, 2010). Naturally, it is a predecessor of vitamin A, and found in several yellow fruits and vegetables. These organic nutrients play a vital role in aiding vision, skin growth, and bone development. In addition to these crucial roles, Beta-carotene may be of significant help in regulating the blood sugar in diabetic persons (Gutiérrez, & Gonzalez, 2010). Human bodies regulate blood sugar levels with the help of the hormone called insulin. In the absence or inadequate supply of this hormone, an individual is said to be diabetic. Diabetes may results in solemn conditions such as blindness, heart diseases, and stroke. Over the years, medical
Many people think that fruit juices are healthy because they are made out of fruit. However, they are not good for a diabetic. Fruit juices have just as much sugar as soda, which can cause a
The goal of eating the fruit food group was to consume an approximate 1 1/2 cups. Carry out this goal, consuming more fruits as snacks or during my breakfasts, replacing it with other foods. Compliance with this food group was satisfactory since it consumed varied and good fruits of flavor where it could vary them in the meals. In many cases, the limit of the amount of intake was passed, consuming fruits that contained a higher level of sugar and
Kale has antioxidant identified as alpha-lipoic acid that helps lower the blood glucose levels, improves insulin sensitivity and prevents against oxidative stress- developed in people with diabetes. Studies have done on alpha-lipoic acid and their results have shown reduction in peripheral
Mulberry and blueberry are examples of the berries species that contain high antioxidants and low in calories. These berries may contribute in minimizing and preventing the risk of diabetes due to the presence of high amounts of phenolic compound and flavonoids such as anthocyanin. It may exhibit neuroprotective and anticancer activity (Wang Y, Xiang L, Wang C, Tang C, He X, 2013). The reaction of the antioxidants in berries related to the reduction of oxidative stress and inhibition of macromolecular oxidation in fruits that high in phenolic compound (Larson, 1988). The anthocyanin content also have other health-related function such as anticancer, antiaging and antiobesity. However, the research regarding these functions still in progress and some of the research still needs a further improvement. The rich content of poplyphenol in berries helps in reducing the oxidation and producing the insulin to reduce the blood glucose
Based on the analysis of recipe, the nutritional facts for the whole recipe per yield of Mango Rice Drink with Mint declassify nutritional grade B+ based on a 2000 calorie diet. For two serving size of the rice drink will give you 53 kcal. Based on the information that give on the nutritional facts, rice drink product is a healthy product because it is does not have cholesterol and very low in saturated fat. In addition, the rice drink products are high in Vitamin C, high in manganese and very low in sodium. Our product low in cholesterol because the core ingredients of rice drink is rice, so in rice does not have cholesterol but high in sugar which is from carbohydrates. Do you know that Vitamin C is an antioxidant and evaluation from its
The Effect of Aqueous exatract of Tamarindus indica L. Seeds (TIE) and Crocus Sativus (CSE) on Fructose-Induced Metabolic Syndrome in Rats
This study is imperative for the growth of knowledge on diabetes. Recent studies have identified the rise of diabetes cases and how the disease is running out of control. This study explains the basic terms of diabetes and how it can be prevented and managed naturally. The study points at creating awareness of the prevalence of the disease. The research explains that in every 20 people in the world’s population, 1 has diabetes. Most of the death cases resulted in diabetes are because of unaffordability of the treatment. However, this study is aimed at
A diabetic diet is an eating plan or diet recommended for people with diabetes mellitus to assist them in controlling their blood sugar. A diabetes diet is medically known as Medical Nutrition Therapy. It is rich in nutrients, low in fat and calories and high in vegetables, fruits and whole grains. In such a diet, individuals are encouraged to eat moderate amounts of food and stick to regular mealtimes. The importance of eating dietary fibre is emphasised in such diets and it is even said that carbohydrates eaten with dietary fibre results in a lower glycaemic status (level of sugar in the
Diabetes directly caused 1.5 million deaths in 2012(Global reports on diabetes, WHO, 2016). Diabetes is a result of improper functioning of carbohydrate and lipid metabolism resulting in resistance to the insulin being produced by the pancreas which finally results into higher blood glucose levels. It can further lead to many complications such as retinopathy, hyperlipidemia, atherosclerosis, hypertension, neuropathy and nephropathy if not managed. There is strong evidence suggesting that T2DM is a result of failure of beta-cells in the pancreas. It starts as a decrease in the response by the peripheral tissues to insulin (insulin resistance) and gradually affects the functioning of beta-cells of pancreas, finally resulting in severe destruction of the cells and hence there is little or no insulin production in the body which results in impaired glucose tolerance and elevated blood glucose levels[1]. Controlling diabetes involves changes in dietary habits, exercise and use of conventional medications. However, traditional medicines can have adverse side effect and can be expensive. Lot of investigations continue to be done to check the efficacy of natural medicinal herbs and spices to manage a whole range of diseases including diabetes
Some, like dark chocolate will reduce insulin resistance, improve insulin sensitivity, drop insulin levels, fasting of blood glucose and will stop blunt cravings. Oily fish like salmon and raw vegetables like broccoli have anti-inflammatory benefits and can even improve blood sugar control and protect blood vessels. And fruits like berries helps flush fat out of the system. All of these ingredients are regularly used to make delicious dishes for
Enhanced oxidative stress and changes in antioxidant capacity, found in both clinical and experimental diabetes, are thought