Antibiotic Resistance By Bacteria, Viruses, Antibiotics, And Antibiotics

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Background/Statement of Problem(s):One of the most critical challenges confronting the application of chemotherapeutic agents in general, and antibiotics in particular, is the development of resistance by target microbes such as bacteria, viruses etc. In most instances, antibiotic resistance, which is a natural phenomenon, occurs when bacteria undergo or acquire mutation to alter the target sites of drugs. As target microbes becomes less responsive to the inhibitory and killing effects of antibiotics, the unfettered multiplication that results leads to therapeutic failure with consequent morbidity and or mortality. This has been a serious and growing public health issue to which there has not been an effective solution.The traditional answer to this problem has been to introduce new antibiotics that kill the resistant mutants. Unfortunately, the pharmaceutical industry is now producing too few antibiotics, particularly against Gram-negative organisms, to replace antibiotics that are no longer effective for many types of infection. This paper reviews possible new ways to discover novel antibiotics.

Supporting Data:Over the past century of antibiotic discovery and development, few parallel and independent lines of discovery have been fruitful. The development of strategies to prevent the evolution of resistance strains of microbes has been a top priority. In clinical practice, several measures that have been tested to reduce the incidence of resistance development, including
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