Antibiotics And Respiratory Infection

In the last decade, the number of prescriptions for antibiotics has increases. Even though, antibiotics are helpful, an excess amount of antibiotics can be dangerous. Quite often antibiotics are wrongly prescribed to cure viruses when they are meant to target bacteria. Antibiotics are a type of medicine that is prone to kill microorganisms, or bacteria. By examining the PBS documentary Hunting the Nightmare Bacteria and the article “U.S. government taps GlaxoSmithKline for New Antibiotics” by Ben Hirschler as well as a few other articles can help depict the problem that is of doctors prescribing antibiotics wrongly or excessively, which can led to becoming harmful to the body.

It is thought that overuse of antibiotics is related to the development of antimicrobial resistance (AMR) (Austin). As a consequence, there has been an increasing trend to promote appropriate prescribing of antibiotics so as to maximise their therapeutic efficacy and minimise the outbreak of resistance. Antimicrobial stewardship (AMS) programs in hospitals are exemplary of a method used to promote rational prescription of antibiotics. In this review, we will briefly introduce some examples of AMR to illustrate the extent of this issue. We will then move on to describe AMS programs and the strategies required to

The most frequently reason for prescription of antibiotics was abscesses, 170/464 (37%). The most widely used NSAIDs were Par¬acetamol (Acetaminophen), resulting in 270/464 responses (58.2%). The most commonly prescribed antibioticswas Amoxicillin (n = 344, 74.1%). Only 4.4(8.8%) of the participants followed the WHO guide for good prescription. Female students showed significantly more errors than their male counterparts regarding the dose and drug’s brand name; p=0.002,p= 0.030, respectively. There was a significant reduction in prescription errors with the increase of the students’ educational level (p=0.001), and students from public universities showed more errors in knowing brand names and duration of treatment comparing to those from private universities

Antibiotics, composed of microorganisms such as streptomycin and penicillin, kill other infectious microorganisms in the human body. At one point, antibiotics were considered to have “basically wiped out infection in the United States”, but due to their overuse and evolutionary

Fleming in 1928. Penicillin helped to treat some common infections: step throat, boils, it would heal wounds quicker, as well as treat more serious infections such as meningitis and pneumonia. Antibiotics usually kill only weak bacteria and after some years of antibiotic usage stronger bacteria have not only survived but also became resistant to the old cure. “Doctors have started to prescribe antibiotics to cure conditions such as ear infections, sinusitis, bronchitis, non-specific upper respiratory tract infections and even common colds and flu… According to the Director of Antimicrobial Resistance, Dr. Richard Besser, each year US physicians write $50 million worth of prescriptions that are ineffectual and unnecessary.” (Elisa Bussey). The more doctors were prescribing antibiotics, the bigger the number of people who become resistant to them. Most of the European countries prescribe antibiotics to kill bacteria only in cases of life threatening conditions. Patients in the US have become accustomed to receiving antibiotics for almost any health concerns and with time, patients have started to expect such prescriptions as a norm.

The confusion begins with the public, and their views on the topic. The research into public perception of antibiotics has occurred multiple times, each leading to a similar conclusion: the lack of awareness leads to false perceptions about the effects of antibiotics. Per the World Health Organization (WHO), surveying 10,000 people, 64% of individuals who responded believed that antibiotics could treat the flu and the cold. This is especially odd since the same percentage of people believed that AMR “is an issue that could affect them and their families” (World Health Organization). Due to the constant confusion, about if

Antibiotics are inarguably one of the greatest advances in medical science of the past century. Although the first natural antibiotic Penicillin was not discovered until 1928 by Scottish biologist Alexander Flemming, evidence exists that certain plant and mold growths were used to treat infections in ancient Egypt, ancient India, and classical Greece (Forrest, 1982). In our modern world with the advent of synthetic chemistry synthetic antibiotics like Erithromycin and its derivative Azithromycin have been developed. Antibiotics have many uses including the treatment of bacterial and protozoan infection, in surgical operations and prophylactically to prevent the development of an infection. Through these applications, antibiotics have saved countless lives across the world and radically altered the field of medicine. Though a wonderful and potentially lifesaving tool, antibiotic use is not without its disadvantages. Mankind has perhaps been too lax in regulation and too liberal in application of antibiotics and growing antibiotic resistance is the price we must now pay. A recent study showed that perhaps 70% of bacterial infections acquired during hospital visits in the United States are resistant to at least one class of antibiotic (Leeb, 2004). Bacteria are not helpless and their genetic capabilities have allowed them to take advantage of society’s overuse of antibiotics, allowing them to develop

Every year a familiar scene plays out in clinic waiting rooms, chairs filled with miserable patients waiting to see their physician with complaints of a never ending cough and a constant nasal drip. More than likely, these patients will receive a prescription for antibiotics, but should they? Most acute respiratory tract infections (ARTIs), do not require an antibiotic, the symptoms will resolve themselves over time without antibiotic treatment. Healthcare experts and scientists have warned the public about the dangers of overusing antibiotics, and there are thousands of studies to support that fact, but no one is listening. Patients are convinced they need to have antibiotic treatment, and somehow their time is wasted if they leave empty

Antibiotics differ from many other drugs in the fact that the treatment is for a very short time compared to drugs used to treat hypertension, diabetes, Parkinson’s, or cancer. The latter disorders have in common that the treatment, from the moment of diagnosis, is life-long. The treatment period for antibiotics is only a few weeks, making the return of investment poor. Increasing demands of authorities in both development and marketing phase and in legislation increase the costs of new antibiotics.[1] [3]

Although declining, inappropriate antibiotic prescribing continues to be a problem, especially the use of broad-spectrum antibiotics for infections of predominantly viral etiology, increasing risk for developing drug-resistant infection complications (Aspinall, Good, Metlay, Mor, & Fine, 2008; Garau & Dagan, 2003). Few interventions have been effective in moderating antibiotic overuse for acute URTIs (Legare et al., 2012). Emphasis on infection control alone is inadequate to address the rise of resistant infections. Judicious prescribing is the

Upper respiratory tract infections (URTI), including acute otitis media (AOM) are the most common cause of ambulatory physician visits and antimicrobial prescriptions in children1,2. The most common bacterial causes of URTI are Streptococcus pneumoniae and Haemophilus influenzae, though the majority of cases are caused by viral pathogens 3–10. Distinguishing between viral and bacterial URTI can be difficult. Reports on quality of antimicrobial prescriptions have shown a 30-50% of all out-patient prescriptions due to (upper) respiratory tract infections to be inappropriate2,10,11. In Europe the quality of prescription is higher in the north of the continent, including Iceland compared to in the south12. Conversely, many factors contribute to the overuse of antimicrobials2,13–15, which in turn results to increase in antimicrobial resistance16,17. Contributing factors cited by by physicians to cause over-prescription include uncertainty of diagnosis, fear of disease complications, lack of perception of harmful effects of antimicrobials, not perceiving their own prescription practices to be a problem, pressure by patients, limited time, fear of damaging doctor-patient relationship in addition to language, cultural and educational barriers2,13–15. Antimicrobials were long a mainstay treatment against AOM in fear of rare, but dangerous complications, which have later been found to be unfounded, asnd

Research has revealed how overprescribing antibiotic creates several adverse outcomes, including the development of multidrug resistant organisms, Clostridium difficile infection, and increased costs of health care (Myung et al., 2015). The Consumer Report (2015) raised concern for the overuse of antibiotics and how it leads to the loss of the ability to treat serious infections. Doctors,

It stands to mention that antibiotics are usually not prescribed for treating bronchiolitis. They are not effective because this illness is caused by a virus. In some instances, such drugs are necessary when the state of health is complicated by a bacterial infection (pneumonia and ear infection).

Antibiotics-resistant organisms have become one of the most serious threats to public health, infecting over two million people and killing approximately 23,000 people annually.1 According to the CDC, “total inappropriate antibiotic use,” such as prescribing unnecessary antibiotics or giving the wrong dose or duration, makes up to 50% of all outpatient antibiotic use,2,3 and in 2009, the United States spent $10.7 billion on antibiotics, indicating that there is a lot of potential money to save.4

FDA issued a black box for the increased risk of mortality during tigecycline treatment for severe infections, especially for hospital-acquired pneumonia or ventilator-associated pneumonia (2). Further assessment of the cause of excess deaths in these trials may in part be attributed to suboptimal tigecycline dosing. Due to these findings, several clinical studies were conducted by increasing tigecycline dosing and obtained positive efficacy compared with other dose regimens (3, 4). High dose tigecycline may be a desirable treatment strategy, but the degree of increment of tigecycline for different infections cannot be generalized in a fixed high dosing. Optimization of tigecycline high-dose regimens for dissimilar infections is needed.