Antioxidants And The Human Body

Twenty healthy, age-matched (36 years of age, on average) subjects were randomized to either receive 200 mg of Polygonum cuspidatum extract (PCE) (containing 40 mg of resveratrol) or a placebo daily for 6 weeks. Blood samples were collected at baseline and at 1, 3 and 6 weeks. Oxidative stress was determined by analyzing blood for reactive oxygen species (ROS) generation. Inflammatory state was determined by assessing nuclear NFKB DNA binding activity (via gel shift assay) and TNFα mRNA expression (via PCR testing). Resveratrol supplementation was found to significantly reduce ROS generation, NFKB DNA binding activity, and TNFα mRNA expression compared to both baseline and the placebo group at 3 and 6 weeks. (see figure 1). The authors therefore concluded that 6 weeks of a resveratrol-containing supplement could reduce both oxidative stress and inflammation. A major weakness of the study is that the authors failed to report the sex of the subjects making it challenging to compare these findings with other studies. Furthermore, this study used a PCE supplement, which contains several other antioxidants in addition to resveratrol. The possibility therefore remains that these other compounds or an interaction effect could have been responsible for some of changes that were observed.

Your body is in a constant battle against infection, diseases and the formation of free radicals. However, there's a secret weapon that can help you fight against these things: antioxidants! Antioxidants are elements such as vitamins A, C and E that counteract the damage caused by free radicals and help protect your healthy cells. Free radicals are the molecules that contain unpaired electrons, which make them highly reactive. In this form, they can cause damage by attacking healthy cells, and when these cells grow weakened, you become more vulnerable to disease.

The roles of antioxidants( Endogenous compounds) are to neutralize the excess of free radicals, to protect the cells against their toxic effects and to contribute in disease

Coenzyme Q10 is a substance you already have in your body. You manufacture it and it converts the foods you eat into energy, as well as acts as a potent antioxidant for fighting free radicals associated with cancer. That might sound like a magic remedy to you, but in reality, it is simply a substance your body needs

Vitamin A (Vitamin Supplements): Vitamin A is an antioxidant that helps protect the body against harmful substances called free radicals. Individuals can boost the vitamin A in their bodies by taking supplements or eating vegetables, especially broccoli, carrots, spinach, kale, and cantaloupe. Vitamin A has also been noted to have anti-inflammatory effects, although the reason why is unknown. A lack of vitamin A has been linked to inflammation in the intestines, lungs, and skin in the past. By taking vitamin A supplements, individuals can reduce their vitamin A deficiency found in conditions like inflammatory bowel disorder and

Grape Seed Extract and oligomeric proanthocyanidins (OPCs) clearly possess remarkable antioxidant properties. Their effects on reducing free radical damage and oxidative stress suggest that they may be particularly effective in reducing the risk of cancer, cardiovascular disease and a number of the chronic diseases associated with ageing. It is 20 times more potent than Vitamin C and 50 times stronger than Vitamin E.

The thinking goes that if you don't have enough antioxidants in your diet, free radicals are able to damage the body and bring increases in LDL and

Each of us has a unique metabolism, a characteristic set of biological conditions (such as DNA, past experiences, living conditions, and behavioral patterns) that determine our needs for certain nutrients, our risks for certain diseases and injuries, and the efficacy of drugs and supplements. With the seemingly general lack of awareness of this fact, the amount of misinformation out there and the conflicting nature of scientific findings, any one of us looking for greater vitality and longevity can easily find ourselves take shot after shot in the dark, until maybe stumbling into something that works. (If we're

Antioxidants can normally neutralize a radical molecule before it damages a cell membrane or a DNA strand, but one of the facts of age is that older skin has fewer antioxidants. As a result, there are more free radicals and more damage

antioxidant enzymes including small-molecule-weight antioxidants depends on cellular redox environment as it is a delicate process to regulate the two. ROS are responsible to regulate several physiological actions such as the ability to mediate and relate signal transduction from membrane receptors, At low concentrations, ROS are involved in regulating several physiological actions, including their ability to mediate relate signal transduction from membrane receptors, thus aiding the stimulation of several proteins and enzymes (1,2). Conversely, accumulation of extra intracellular ROS lead to oxidative stress, in turn will impair cellular membranes, promoting mitochondrial injury and cell death, which adversely impacting upon cell function and survival 3,5)

many chronic disease also like cancer , heart disease . Vitamin C protect us from all these disease attack.

Vitamin C is an antioxidant, along with vitamin E, beta-carotene, and many other plant-based nutrients. Antioxidants block some of the damage caused by free radicals, substances that damage DNA. The build-up of free radicals over time may contribute to the aging process and the development of health conditions such as cancer, heart disease, and arthritis.

Chocolate has two groups of antioxidants called flavonoids and polyphenols. Antioxidants fight against free radicals in the body. Free radicals are unbalanced compounds created by the natural cellular processes in the body and from environmental toxins. Antioxidants are compounds including vitamins, minerals and phytochemicals that neutralize free radicals and protect the body from their damage. The substances in antioxidants counteract with the damaging normal effects of the body’s process of oxidization. Research shows that antioxidants help in preventing the development of chronic diseases such as cancer, heart disease, stroke, Alzheimer’s, rheumatoid arthritis, and cataracts.

Antioxidants are substances that stable enough to prevent or retard the oxidation of easily oxidisable biomolecules such as lipids, proteins and DNA, thus preventing oxidative damage (Lobo et al. 2010). Antioxidants can be classified into two classes, according to their action, into primary or chain breaking antioxidants and secondary or preventative antioxidants. Primary antioxidants, when present in low concentration, can either delay or inhibit the lipid oxidation by reacting with a lipid radical or peroxyl radicals. Secondary antioxidants on the other hand, retard the rate of oxidation by chelating of metal ions or quenching of singlet oxygen (Amalia et al. 2005). These antioxidants are widely used as food additives in foods,

1. Antioxidant properties: Some dietary resources can provide the antioxidants missing in our body 's natural regulating machinery. An excellent example of this is the Aloe vera which is a functional food that plays a significant role in protecting our organism from oxidative stress, not only because of its content of antioxidant constituents, but also for its ability to activate the body 's natural protective systems. The antioxidants contained in Aloe vera (vitamin C, E, zinc and seven superoxide dismutases), work primarily by scavenging free radicals. Among the multiple benefits of dietary antioxidant intake, researches have demonstrated its inverse relationship with the development of cardiovascular diseases. Still other studies have shown preventive or attenuating effects of dietary antioxidant consumption in virtually every other chronic disease related to oxidative stress (Total Health, 2007).