Antipsychotic Medications and Yoga Therapy as an Adjunct Treatment for Schizophrenia
Sarah Garrabrant
University of South Florida
Introduction
Schizophrenia is a severe form of mental illness classified in the DSM IV-TR as a Psychotic disorder. It is characterize by broad impairments in cognition that place limitations on recovery (Eack, 2012, p. 235). Antipsychotic drugs are the first line of treatment for Schizophrenic patients, but come with adverse side-effects and many patients are treatment-resistant (Tandon, Nasrallahb, & Keshavanc, 2010). Adjunct treatments that focus on cognition and coping with stress, along with the antipsychotics have shown to be more effective (Sungur, Soyguur, Guuner, Uustuun, Cetin, &
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Typical antipsychotic drugs occupy around 70-90% of D2 receptors at a common dosage (Kleinman, Casanova, & Jaskiw, 1988).
Due to side effects and the nature of the illness, some patients do not keep continuous use of anti psychotic treatment. It has been found that patients with light use of antipsychotics were more likely to be hospitalized than continuous users. The average duration of anti-psychotic use was six months in any single year and compared to individuals with a continuous pattern of anti psychotic treatment, individuals with moderate or light use had odds for hospitalization, 52 or 72% greater (DosReis, Johnson, Steinwachs, Rohde, Skinner, Fahey, & Lehman, 2008). First generation and Second-generation antipsychotics
Researchers wanted to know who was more effective, first generation antipsychotics or second-generation antipsychotics (Kane, 1999). The CATIE trial compares first and second generation antipsychotics, comparing first generation perphenazine with second generation drugs, olanzapine, quetiapine, risperidone, and ziprazidone. Overall, olanzapine did better than other treatments,. What surprised researchers most is that first generation antipsychotic, perphenazine, was similar in effectiveness to three of the four second-generation antipsychotics (Liberman & Stroup, 2010). It has been found that 30% of patients fail to
Schizophrenia treatment has developed to have two specific classes of drugs, typical antipsychotics and atypical antipsychotics. Typical antipsychotics were the first type of drugs to be used on schizophrenia patients. They are also known as the ‘first-generation’ drugs. Atypical antipsychotics, or ‘second-generation’ drugs are newer drugs that are now often used in replacement of the ‘first-generation’ drugs. However this progression of drug treatment for schizophrenia patients has shown little change in effectiveness as studies were unable to find distinct difference. The only real difference between the two can be seen in their prices and side effects. Although, the typical antipsychotics have now tapped into the fast-growing generic drug
For the treatment of bipolar disorder, antipsychotic medicines are sometimes prescribed to treat episodes of mania or hypomania. Examples of antipsychotic medicines include: aripiprazole, olanzapine, quetiapine and risperidone. These drugs may also be used as a long-term mood stabiliser and quetiapine can be used for the treatment of bipolar depression in the long-term. Antipsychotic medicines can be particularly useful if symptoms are severe or behaviour is disturbed. As there is a chance that the antipsychotics could cause side effects, the initial dose will usually be low. These side effects could include weight gain, blurred vision, constipation and dry mouth. If prescribed an antipsychotic medicine, regular health checks will be required at least every three months. If the symptoms don 't improve, the patient may be offered lithium and valproate as well.
Antipsychotics are medications that physicians use to treat psychotic disorders such as Schizophrenia, Delusional disorder, Paraphrenia, and Substance-induced psychotic disorders. These disorders are characterised by the patient’s inability to make good judgments, think with a clear head, communicate effectively, relate to society, and understand reality. Antipsychotic drugs are also useful in the treatment of bipolar conditions that involve extreme cases of manic behaviour. Examples of these drugs include Thorazine and Trilafon. These drugs belong to a drug class called phenothiazines. They work by changing the actions of chemicals in the brain. The drugs can be beneficial, however, Steen et al. (2014) argue that the medicines have several harmful effects such as changes
For most individuals with schizophrenia, a thorough treatment plan is vital to assist with medication adherence, reduce hospitalization and to provide improvement in quality of life. Typically a prescription for antipsychotics is necessary not only to reduce positive
The management of schizophrenia is complex and requires an “all-encompassing approach” which should be individualized to meet the needs of a particular patient (Schizophrenia Society of Canada, 2016, para. 5).
As we have seen, treatment of schizophrenia with antipsychotic drugs can have impressive results in terms of decreasing active symptoms, although it does nothing to alleviate negative symptoms or to improve cognitive functioning. Unfortunately, this kind of treatment has the drawback of extremely serious and even fatal side-effects. Newer generation atypical antipsychotics offer more hope, as they can treat both active and negative symptoms, and also improve cognitive functioning. Moreover, they have fewer side-effects. However, treatment is complicated by the fact that results are unpredictable; and in addition the side-effects that they do have can be very serious, such as diabetes, which in itself is life-threatening. However, as the potential side-effects are known, the physician has leeway to choose a drug which is a good match for the patient’s clinical profile. Then, once the patient’s symptoms have been much alleviated with an appropriate newer generation atypical antipsychotic, the patient should be able to also benefit from a range of psychotherapeutic interventions. It is argued that this is the best treatment regime to choose, as it is likely to result in the greatest improvement in quality of life, coupled with the lowest risk of potentially devastating side-effects, or of death. This is likely to be better than utilizing cognitive behavioral therapy, the results of which are not reliably known – although research has certainly shown that it is less efficacious
Schizophrenia is a life-long disorder that affects about one percent of the population (Mueser & McGurk, 2004). The cause of this mental illness is still unclear. Studies have suggested that Schizophrenia does not arise from one factor but from a combination of genetic, environmental, and social factors (Liddle, 1987). People diagnosed with Schizophrenia struggle to deal with a multitude of symptoms that make it difficult to function (Mueser & McGurk, 2004). Antipsychotic medications are a popular treatment of the symptoms of Schizophrenia (Mueser & McGurk, 2004). Research is constantly being done to develop these medications to enhance the quality of life of those diagnosed with Schizophrenia.
Antipsychotics are generally used to treat psychosis in mental disorders. These disorders include schizophrenia and bipolar disorder (Thyssen et al., 2010). Risperidone is known as an atypical second generation antipsychotic and used in the treatment of a multitude of disorders. This medication can often challenge behavioral problems that are associated with schizophrenia, autism spectrum disorder, bipolar disorder, or attention deficit hyperactivity disorder (Schatzberg & Nemeroff, 2013). It is important for the prescriber to be aware of the side effect and any possible adverse reactions that may occur. There can be many detrimental side effects that someone may not enjoy,
Seeman, P. (2002). Atypical antipsychotics: mechanism of action. Canadian Journal of Psychiatry, [online] pp.27-38. Available at: https://www.ncbi.nlm.nih.gov/pubmed/11873706 [Accessed 11 Nov. 2016].
Antipsychotics are primarily used to manage the symptoms of psychosis, particularly schizophrenia and bipolar disorder by blocking D2 receptors in the dopamine pathway of the brain. There are two main types of antipsychotics; typical antipsychotics, also known as the first generation antipsychotics (FGA) which were developed in 1950s, example of medicine in this category include Chloropromazine, Haloperidol, Flupenthixol, and Loxapine. Atypical antipsychotics, also referred as second generational antipsychotics (SGA) which acts as an antagonist for 5HT2A receptor aside from its blocking effect on D2 receptor, drugs in this class include Olanzapine, Quetiapine, Risperidone, Clozapine and Aripiprazole.
Clearly, this is a very serious disorder, which is often utterly incapacitating. Therefore, individuals urgently require efficacious treatment, both for survival and for quality of life, and many different kinds of treatment and therapy are used. This paper will examine the use of two of these, cognitive behavioral therapy and drug therapy, and evaluate which one is better. It will take the position that drug therapy is a more effective therapy for treating schizophrenia than is cognitive behavioral therapy.
Schizophrenia is a brain disorder that cannot be cured but there are various types of treatments that are available for lifetime support. Some of which are, Coordinated Specialty Care treatment which is aims at improving the quality of life by giving psychosocial therapies, family involvement, and education support. These specialists will give a certain type of treatment plan to the patients for them to follow and work together to make therapy decisions. Psychotherapy, and this treatment is a way to help patients understand their illness and manage their symptoms better. There are also different types of psychotherapy called Cognitive Behavioral
It was not rare for individuals to have a relapse of their mental illness, this was normally due to inadequate taking of their prescriptions or stopping their medication entirely. Although these pharmaceuticals are effective on the positive symptoms of Schizophrenia they are not as efficient on the negative and can cause involuntary movement cognitive dulling as a
Olanzapine has a better effect on negative symptoms compared to other 2nd generation antipsychotic drugs (Werner, 2015), and is one of those second generation antipsychotic medicine approved for the treatment of schizophrenia
Considering the times of data collection, the studies suggest that the use of typical antipsychotics was reducing, while the use