Experimental Design and Aortic Stenosis Model All experiments and procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health and were approved by the Animal Ethics Committee, São Paulo State University (#198). Three- to four-week-old male Wistar rats weighing 90–100 g were anesthetized with a mixture of ketamine (50 mg/kg, i.p.) and xylazine (10 mg/kg, i.p.). A total of 10 rats were submitted to aortic stenosis surgery, which involved placing a 0.6-mm-i.d. stainless steel clip on the ascending aorta via a thoracic incision (29). A total of 5 age-matched control animals underwent left thoracotomy without clip placement (Sham group). The rats were housed in collective polypropylene cages (2 animals per cage) covered with metallic grids in a …show more content…
The animals were given standard rat chow (Labina; Purina, SP, Brazil) and water ad libitum. At 18 weeks after surgery, when the AS animals presented with cardiac dysfunction as measured by echocardiography, the AS animals were redistributed randomly into 2 groups: heart failure sedentary (HF-S, n = 5), in which the group of AS rats remained untrained over a 10-week period, and heart failure ET (HF-ET, n = 5), in which the AS rats that were subjected to 10 weeks of aerobic ET. The ET protocol is described in detail below. Previous data from our laboratory show that rats with AS start to exhibit evidence of heart failure approximately 21–25 weeks after surgery (59). Thus, after 28 weeks, all 3 groups underwent another
The prevalence of congestive heart failure is on the increase both in the United States and all over the world, and it is the leading cause of hospitalization in the elderly population. Congestive heart failure is a progressive disease generally seen in the elderly, which if not properly managed, can lead to repeated hospital admissions or death. Heart failure means that the heart muscle is weakened. A weakened heart muscle may not be strong enough to pump an adequate amount of blood out of its chambers. To compensate for its diminished pumping capacity, the heart may enlarge. Commonly, the heart's pumping inefficiency causes a buildup of blood in the
In Falcon’s report “Heart Disease” he anatomically describes the heart as “a fist sized organ located in the lower left quarter of the chest…[consisting] of four chambers: the right and left atria on top and the right and left ventricles at the bottom” (Falcon). While the heart is one of the smaller organs in the body, it has an enormous and important job to do; deliver nutrient carrying blood to the tissues in the human body. In people with heart disease, the heart is impeded and cannot efficiently deliver nutrients and oxygen to structures such as our muscles or our brain. This is one of the reasons that heart disease is so deadly; when our body structures are deprived of necessary nutrients, they begin to breakdown. The term “heart disease” encompasses a wide variety of
Heart Failure is a progressive heart disease when the muscle of the heart is weakened so that it cannot pump blood as it should; the blood backs up into the blood vessels around the lungs and the other parts of the body (NHS Choice, 2015). In heart failure, the heart is not able to maintain a normal range cardiac output to meet the metabolic needs of the body (Kemp and Conte, 2012). Heart failure is a major worldwide public health problem, it is the end stage of heart disease and it could lead to high mortality. At present, heart failure is usually associated with old age, given the dramatic increase in the population of older people (ACCF/AHA, 2013). In the USA, there are about 5.7 million adults who have heart failure, about half of the people die within 5 years of diagnosis, and it costs the nation an estimated $30.7 billion each year (ACCF/AHA, 2013).
Although these interventions may improve immediate survival in the short term, only coronary artery revascularization and cardiac transplantation have been shown to improve long-term survival.” (DeMarco & Chatterjee, 1993)
Heart failure affects nearly 6 million Americans. It is the leading cause of hospitalization in people older than 65. Roughly 550,000 people are diagnosed with heart failure each year (Emory Healthcare, 2014). Heart failure is a pathologic state where the heart cannot pump enough blood to meet the demand of the body’s metabolic needs or when the ventricle’s ability to fill is impaired. It is not a disease, but rather a complex clinical syndrome. The symptoms of heart failure come from pulmonary vascular congestion and inadequate perfusion of the systemic circulation. Individuals experience orthopnea,
Heart failure (HF) is defined as a multifaceted clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. In HF, the heart may not provide tissues with adequate blood for metabolic needs, and cardiac-related elevation of pulmonary or systemic venous pressures may result in organ congestion1. In the United States, HF is increasing in incidence with about 5.1 million people suffering from HF and half of people who develop HF die within 5years 2. Over 75% of existing and new cases occurred in individuals over 65 years of age, < 1% in individuals below 60 years, nearly 10% in those over 80 years of age. HF costs the
Mountings of evidence exist on the benefits of physical activity and exercise for patients who have experienced a heart failure (HF) in recent years. HF occurs irrespective of age, therefore there will be no age categorisation within this report even though it is decidedly prevalent in older people, however, distinction will be made in relation to the group most likely to experience an event where pertinent. Owing to that, the intent of this report will be to asses the impact of physical activity and exercise on mortality and morbidity outcomes of those who have experience an event, as well as the advancement of quality taking into account the prognosis of the patients and their ability to undergo a particular exercise prescription.
Congestive heart failure (CHF) is a syndrome that occurs when the heart cannot pump sufficient blood to meet the tissues metabolic and oxygen needs. As a result, intravascular/ interstitial volume overload and poor tissue perfusion occurs. An individual with heart failure experiences reduced exercise tolerance, a reduced quality of life and shortened life span. The most common cause of heart failure is coronary artery disease (CAD). The incidence of heart failure increases with age. Approximately 1% of people over the age of 50 and 10% of people over the age of 80 experience heart failure. The prognosis depends on underlying cause and response to treatment. Heart failure may be classified according to the side of the heart affected.
Systolic heart failure results from the inability of the cardiac muscle to contract effectively from inadequate cardiac output. As the cardiac output drops, compensatory mechanisms to try to restore its function through takes place by ventricular remodeling. During this remodeling phase, the heart begins to develop changes in its size and becomes hypertrophic that results in a decreased ability of the heart to contract, decreased available oxygen, and available ATP. Secondly, this hypertrophic states increases preload that results
Patients with chronic heart failure present with decreased exercise tolerance. It is important that a well-designed exercise prescription is followed at all times and the appropriate health care provider such as the cardiologist is in agreement with your treatment plan. Query the physician if there is any specific exercise precautions or guidelines that are distinct to the patient. Furthermore, these particular patient populations may sometimes overexert themselves. Symptoms such as dyspnea, dizziness or lightheadedness,
Heart failure is term that is used to describe the heart’s inability to work efficiently as a pump. In order to decipher if an individual is likely to have heart failure is through their health history. Common backgrounds associated are diabetes mellitus, kidney dysfunction, hypertension, chronic lung disease, angina, myocardial infarction, and ischemic heart disease (Kirk, 2011). It is accompanied by shortness of breath on exertion, decreased exercise tolerance, paroxysmal nocturnal dyspnea, orthopnea, ankle swelling, sudden weight gain, lack of appetite or nausea and difficulty concentrating (Kirk, 2011). In worsening conditions it could progress to fluid buildup, rapid or irregular heartbeat, chest pains , and sudden
Heart failure is a syndrome that involves dysfunction of the cardiac muscle that results in or increase the risk of developing manifestations of low cardiac output and/or pulmonary or systemic congestion (Grossman & Porth, 2014). The National Heart, Lung, and Blood Institute estimate that about 5.8 million people in the United States have heart failure. Even though heart failure can occur in any age group, it primarily affects older adults. Although morbidity and mortality rates from other cardiovascular diseases have decreased over the past several decades, the incidence of heart failure is increasing at an alarming rate. Approximately 400,000 to 700,000 people are diagnosed with heart failure each year (Grossman &
To fully know what happens in congestive heart failure, it is important to be acquainted with how the heart functions and its anatomy. There is two independent
In year 2000 and 2010, an estimated 1 million hospitalizations for Congestive Heart Failure (CHF), of which most of these hospitalizations were for those aged 65 and over, the share of CHF hospitalizations for those under age 65 increased from 23% to 29% over this time period (Hall, Levant, & DeFrances, 2012). According to Held (2009), acute decompensated heart failure (ADHF) ensues when cardiac output fails to meet the demand of the body’s metabolic needs. The fluid volume overload makes the unstable condition necessitates instant treatment for the reason that it impairs perfusion to systemic organs, endangering their function.
As the population ages heart failure is expected to increase exceptionally. About twenty-two percent of men and forty-four percent of women will develop heart failure within six years of having a heart attack. “Thirty years ago patients would have died from their heart attacks!” (Couzens)