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Apoa-1 Lab Report

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CONCLUSION Apoliproteins are important players in cholesterol homeostasis. ApoA-I acting as a major HDL component is involved in both HDL biosynthesis and transport. In diseases of the CNS where BBB is compromised, such as MS a healthy cholesterol homeostasis becomes extremely important for neuronal status and regeneration. In as much as S1P receptor agonist fingolimod, Apo-I’s function is not completely understood in this disorder. However all implications are in favor of positive neuroprotective effect of this lipoprotein on the CNS. Reduction in ApoA-I levels is not causation for MS, however for progressive patients maintaining healthy levels of HDL/ApoA-I should result in better neuronal health. Agents designed to improve ApoA-I production

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