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Arterial Remodelling

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Non-heamoidynamic factors and arterial remodelling in chronic uraemia: Arterial remodelling is already observed in patients at the start of renal replacement therapy and is comparable in patients on peritoneal dialysis and patients treated by hemoidialysis. This suggests that non-hemodynamic factors could play an important role in the pathoiphysiology of vascular complications. As shown experimentally, the endothelium influences the mechanical and geometric properties of large arteries, and removing the endothelium causes an increase in arterial diameter (Levy et al., 1990). Endothelial function is altered in ESRD patients (Joannides et al., 1997) (Gris et al., 1994) (Van Guldener et al., 1998), and these alterations are associated with arterial

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