Arthritis: Multifactorial And Complex Genetic Disease

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. While inflammation of the tissue around the joints and inflammatory arthritis are characteristic features of rheumatoid arthritis, the disease can also cause inflammation and injury in other organs in the

Rheumatoid Arthritis, what is it? The word Rheumatoid comes from the greek word referring to rheumatism, which means any painful disorder from the joints. Arthritis means inflammation of the joint. (William Collins Sons & Co. Ltd. 1979). Putting these two words together Rheumatoid Arthritis creates a disorder. The pathophysiology of RA is that it is a chronic, systemic, inflammatory autoimmune disease which means that this disorder is attacking your own body (Silvestri, 2013, p. 851 ). This usually happens at the joints where two bones meet that create movement of body parts. This disorder is systemic and usually if it happens one side,

Rheumatoid Arthritis or (RA) is an autoimmune disease that attacks the joints and connective tissue. The result is inflammation that produces permanent damage in the joints. Rheumatoid arthritis is a chronic syndrome that tends to be progressive and destructive as compared to Osteoarthritis or (OA), which is more of an age related disease caused by “wear and tear” of the joints. In contrast to (OA), rheumatoid arthritis is characterized by inflammation mostly of the joints, but is a general body disease.

Since rheumatoid arthritis is a systemic disease, it can also affect other organs and tissues, but it primarily attacks the joints in a symmetrical fashion. Rheumatoid arthritis develops from an abnormal immune response caused by exposure to an antigen, in a patient that is genetically susceptible. Autoantibodies develop and attack the patient’s cartilage and synovial tissues once the antigen exposure has occurred (Nelson, 2011). One of the most common

“Rheumatoid arthritis, RA, causes premature mortality, disability and compromised quality of life in the developed and emerging world (cdc.gov).” RA is the most common of chronic inflammatory arthritis. Rheumatoid arthritis is an autoimmune condition; it is a chronic inflammatory polyarthritis, in which more than five joints are affected. Rheumatoid arthritis is a systemic inflammatory disease which it manifests itself in numerous joints of the body. The inflammatory process mainly affects the lining of the joints, usually small joints then leading to many other organs. “Rheumatoid arthritis is a type of chronic arthritis that occurs in joints on both sides of the body. This symmetry helps distinguish rheumatoid arthritis from other types of arthritis. Rheumatoid arthritis may also affect the skin, eyes, lungs, heart, blood, or nerves (webmd.com).”

Rheumatoid arthritis is a disease where the body’s immune system attacks the joints and other healthy cells. This creates inflammation inside of the joints, which then causes swelling and pain in and around the joints. If inflammation goes unchecked,

According to research, rheumatoid arthritis (RA) is the most popular autoimmune disease. RA is known to be a prolonged, systemic disease that causes inflammation. This inflammation can potentially disturb the synovial tissue that is in the body which eventually leads to damage in the joints, disabling functional abilities, and sometimes even leading to death. Many different factors can be held accountable for the diagnosis (Korczowska, 2014). Throughout this display of research many different ranges of aspects will be discussed. This illness is seen in tremendous amounts amongst physical therapy. The etiology, which happens to be the cause of this case of arthritis, and the signs and symptoms, will be revealed. Certain medical and

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that typically affects the small joints in the hands and feet. Unlike the wear-and-tear damage of osteoarthritis, RA affects the lining of the joints, causing a painful swelling that can eventually result in bone erosion and joint deformity. In America, RA is the most common form of autoimmune arthritis, affecting more than 1.3 million Americans. Of these, about 75% are women. The disease most often begins between the fourth and sixth decades of life. However, the RA also can start at any age. In Malaysia, RA affects about 5 in 1000 people. According to Malaysian Statistic on Medicine in 2005, the total drug expenditure in 2005 for the treatment of inflammatory and rheumatic diseases was RM 50.7 million, and form 7.8% of the top 40 prescribed drugs in Malaysia. It was ranked 5th as the highest prescribed group of drugs (MOH, 2004).

Rheumatoid Arthritis (RA) has been a popular disease to study because it can affect any one person regardless of gender, age, and ethnicity. There are several causes of this disease and even still new causes are being discovered every day as scientists are seeking new routes of treatment. Rheumatoid Arthritis affects specific parts of the body such as the synovial membrane, particular types of cells, the skeletal system, and the cartilage located throughout the body. There are treatments that look to prevent Rheumatoid Arthritis in the early stages. Future research holds new and improved possibilities for Rheumatoid Arthritis.

Disease Overview. Rheumatoid Arthritis (RA) is considered the most common autoimmune inflammatory arthritis disease diagnosed in adult patients and affects quality of life and leads to increased mortality rates. It is defined as a chronic, inflammatory, systemic autoimmune disorder characterized by symmetric, erosive synovitis that often leads to joint destruction, deformity, and disability. If left untreated, progression of RA could lead to irreversible joint damage, systemic effects including damage to the heart, lungs, & GI system. Early diagnosis and treatment can prevent long term complications and increase odds of remission.

Hi Kerri, Thanks for your reply. As I mentioned in rheumatoid arthritis (RA), this is an chronic inflammatory disease condition that affects the synoviyal membranes of joints and other organs in the body such as heart , immune system, musculoskeletal system and respiratory system (Stark 2014).

In general Arthritis describes that inflammation that occurs in the joints which can be warmth, redness, pain and/or selling. RA is an ongoing type of arthritis, the symmetric involvements of joints differentiates RA from other arthritis types. normally when one side is effected the other side most likely is also effected such as both knees, hand or/and wrists. Patients with rheumatoid arthritis suffer from Joint pain, stiffness, fatigue etc which can effect their quality of life. In addition to medications clinicians must educate patients on Non-pharmacologic approaches to aid in relief such as the following

Normal wear and tear causes the most diagnosed form of arthritis, Osteoarthritis, otherwise identified as OA. A disease, injury or being overweight can worsen the natural breakdown of cartilage tissue. Another prevalent form of arthritis, Rheumatoid arthritis, otherwise identified as RA, is an autoimmune disorder. RA occurs when your body’s immune system invades the tissues of the body. These attacks affect the synovium, a delicate tissue in joints that produces a fluid that nourishes the cartilage and lubricates the joints. Doctors are still not certain of the cause of RA, but there is scientific evidence that hormones, environmental factors and genes are to blame. A patient's risk of developing arthritis may be higher if the patient has a family history of the disease. While different forms of the disease have different causes, they can all be equally

Rheumatoid arthritis (RA) is characterized by chronic, erosive polyarthritis and the presence of numerous autoantibodies in the serum and synovial fluid and membrane. Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease that manifests in multiple joints of the body. The inflammation leads to erosions in the cartilage and bone and can cause joint deformity. Individuals with RA often experience pain and swelling of the joints. It was estimated in 2005 that 1.5 million people in the United States were afflicted with RA. There are three times as many women than men affected with RA (CDC, 2015).

            Rheumatoid Arthritis is an inflammatory disease affecting joints casuing swelling, stiffness, pain and loss of function.  This autoimmune disease causes the immune system to attack the Hyaline Cartilage around the joints.  This tough, elastic tissue is surrounded by synovial fluid for lubrication and nutrient transfer as the cartlidge is avascular.   The synovium tissue encloses the fluid and is normally 1-3 cells thick composed by firbroblasts and macrophages.  In RA, the white blood cells navigate to the synovium causing synovitis and the syovium thickens to 8 to 10 cells.   As the disease progresses the inflammation destroys the Hyaline cartlidge and the joint begins to narrow.   In the more severe stages,