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Arthroplasty Essay

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Efficacy and Safety in Total Knee Arthroplasty In our review, the focus is on benefits of liposome bupivacaine on management of post-operative pain after TKA procedure. Bramlett et al. (NCT00485693) Phase 2, randomized, double-blind, dose-ranging study evaluated the efficacy, safety and pharmacokinetics of four dose levels of Depo-Foam bupivacaine compared with 150 mg of bupivacaine HCl/epinephrine, in TKA (N=138). Patients with age limit from 18-75 years who were undergoing TKA are allowed to participate in the study. Patients who were pregnant or nursing , using long-acting opioid medication within past 3 days or any opioid medication within 24 hours were excluded from the study. Patients enrolled in the study were divided into three groups on the basis of different dosages of Depofoam bupivacaine. In …show more content…

In group 2, patients received DepoFoam bupivacaine 133 mg, 266 mg, 399 mg. Patients in group 3 received DepoFoam bupivacaine 532 mg. The goal of this study was to evaluate the effects of different doses of liposomal bupivacaine on cumulative pain score by using AUC of numeric rating scale at rest (NRS-R) where (0=no pain and 10= extreme pain) and at activity (NRS-A)after maximal flexion at the joint through Days 2, 3, 4 and 5 after surgery. Safety parameters were also evaluated by AEs, vital signs, wound healing status, scarring, and electrocardiogram results. Results of the study showed mean AUC of NRS-A scores were lower in the DepoFoam bupivacaine at 266-mg, 399-mg, and 532-mg groups compared with bupivacaine HCl through Days 2, 3 and 5, (p>0.05) though the differences is not statistical significant. Mean scores of AUC of NRS-R were also lower for the three highest dose levels

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