Efficacy and Safety in Total Knee Arthroplasty In our review, the focus is on benefits of liposome bupivacaine on management of post-operative pain after TKA procedure. Bramlett et al. (NCT00485693) Phase 2, randomized, double-blind, dose-ranging study evaluated the efficacy, safety and pharmacokinetics of four dose levels of Depo-Foam bupivacaine compared with 150 mg of bupivacaine HCl/epinephrine, in TKA (N=138). Patients with age limit from 18-75 years who were undergoing TKA are allowed to participate in the study. Patients who were pregnant or nursing , using long-acting opioid medication within past 3 days or any opioid medication within 24 hours were excluded from the study. Patients enrolled in the study were divided into three groups on the basis of different dosages of Depofoam bupivacaine. In …show more content…
In group 2, patients received DepoFoam bupivacaine 133 mg, 266 mg, 399 mg. Patients in group 3 received DepoFoam bupivacaine 532 mg. The goal of this study was to evaluate the effects of different doses of liposomal bupivacaine on cumulative pain score by using AUC of numeric rating scale at rest (NRS-R) where (0=no pain and 10= extreme pain) and at activity (NRS-A)after maximal flexion at the joint through Days 2, 3, 4 and 5 after surgery. Safety parameters were also evaluated by AEs, vital signs, wound healing status, scarring, and electrocardiogram results. Results of the study showed mean AUC of NRS-A scores were lower in the DepoFoam bupivacaine at 266-mg, 399-mg, and 532-mg groups compared with bupivacaine HCl through Days 2, 3 and 5, (p>0.05) though the differences is not statistical significant. Mean scores of AUC of NRS-R were also lower for the three highest dose levels
In 1998, the Massachusetts General Orthopedic Associates (MGOA), a specialized unit within Massachusetts General Hospital (MGH), hired Dr. Harry Rubash and Dr. James Herndon, respectively, to help to remedy the annual financial deficits, which were “financed” by dipping into endowment and borrowings from MGH. These financial deficits have been continually getting into MGOA’s mission of providing high-quality patient care, research, and teaching (Barro 3). In the immediate months after accepting their positions of leadership, both Rubash and Herndon steered the hospital into the green turning a modest profit. However, it was clear that their new initiatives wouldn’t be viable for the long term. To do so, Rubash and Herndon proposed a new physician compensation plan. This plan included a development fund tax, a bonus, in addition to periodic adjustments to a base salary based on individual physician performance in regards to how profitable the physician was for MGOA. Initial physicians’ reaction to the proposed plan varied, however, if the case study was an indication, Rubash and Herndon were determined to implement their plan.
MMHS is a successful home health service company which has expanded constantly over the intervening 20 years, with further patient growth forecasted in 2012. The home healthcare business is seasonal with 66% of the entire annual sales occurring in the late Fall and Winter months. The evolving expansion of the agency and seasonality of the business makes cash management challenging for Ms. Ringer and has landed her in the predicament of requiring a loan to pay salaries. Aligning operating expenses to revenue, improving management of operating costs and decreasing the amount of cash in accounts receivable will improve her immediate cash flow crisis. For details see prior question.
Imagine living in a world where everything is super-sized. Imagine having to step on a stool to crawl into bed, or having to climb onto a shelf to be able to reach a light switch. Most of all, imagine having to look up to your much taller younger sister when she speaks to you. Situations like these are what Ivy Broadhead, a teenager with achondroplasia, have to go through everyday.
The patient had a distal open reduction internal fixation on her left and right wrist. She explained to me that she sustained the injury from a fall. According to her, “ both of her wrists broke from that fall”; which I don’t buy. The patient admitted that she has a history of falls, but what I think is that she was getting abused by someone close to her. There’s no logical reason why she should have sustained so many injuries from frequent falls, without a severe medical condition to support them at a young, but what do I know? She has complication on the left side of her head; because of the many falls, she endured in the past. It seems like she falls decreased when her husband passed, not to be cruel or anything. Arthroplasty was also
Rehabilitation for the hip joint is a long, strenuous recovery because it is the major weight bearing joint for the body as well as providing several ranges of motion. Following hip arthroplasty surgery patients are non weight bearing. Initial physical therapy rehabilitation focuses on stretching the hamstrings, quadriceps, hip flexors, abductors muscles. To maintain range of motion, passive and active exercises of the hip and knee are performed. To avoid atrophy of the muscles, strengthening exercises are progressively intertwined at very low intensity levels. As the patient continues muscle strengthening activities, they will begin weight bearing with normal gait. The next stage of rehab is in the closed kinetic chain, which lowers the
Kinesiotherapist monitors exercise programs that helps people regain muscle strength which was lost due to injury or disease. These are the people that study the depths of anatomy and understand how each part of the body works. The kinesiotherapist choose exercises that best suits the patient depending on what the patient’s goal is. The main goal for a kinesiotherapist to make sure the individual can reach their highest point of mobility and strength without causing pain to the individual. Staying faithful to the exercise routines the kinesiotherapist provides is key to being successful. The education requirements are obtaining a four year degree in kinesiology or exercise science, getting CPR certified, classroom study where you must know
Adequate control of postoperative pain following hip and knee arthroplasty can be a challenging task1,2. Previous studies have shown that over 50% of patients undergoing surgery report postoperative pain as a major concern3 .Inadequate control of pain may result in patient dissatisfaction, impaired patient rehabilitation, and prolonged hospitalizations3. The negative influence of postoperative pain on rehabilitation is particularly concerning for patients undergoing joint replacement. Functional recovery and return of muscle strength is dependent on the ability of these patients to comply with rehabilitation. The drawbacks of inadequate rehabilitation are especially cumbersome in hip and knee surgeries, since faster mobilization leads to quicker
Background: Total knee arthroplasty is a successful treatment for improving pain and function in patients with arthritis, however, approximately twenty percent of patients report being dissatisfied with their outcome. Factors affecting satisfaction are reported in the literature, however research explicitly exploring patient dissatisfaction is limited. Understanding factors associated with dissatisfaction are important on several levels: to reduce its incidence, to assist decision-making about whether to proceed to surgery, and to help dissatisfied patients with their specific problems.
In many cases of failure of cemented hip joint, delaminating of femoral stem from Poly methyl methacrylate (PMMA) bone cement occurs. This debonding is also associated with the torsional movements of implant. In order to control micro motion, the design of hip prosthesis should be such that it experiences an even distribution of stress avoiding any possible stress concentration, which may cause failure of the joint. Moreover, the bone density and shape around the implant changes due to various loads on the prosthesis. As bone density changes due to uneven distribution of stress, it alters fixation of the implant. Failure may also occur at cement bone interface, thus it is important to analyze interfacial stresses and micro movements. This study
Anterior cervical discectomy and fusion (ACDF) is the gold standard for surgical treatment of severe, progressive, or refractory degenerative discopathies. Boney fusion is often considered as the key outcome measure for ACDF. While autologous bone graft is the most biocompatible option for achieving successful fusion, this method is associated with donor site complications, such as pain, infection and long-standing functional disability. This wide array of morbidities has led to continuous efforts for improvement of ACDF, through combination with instrumentation and development of graft alternatives. Furthermore, increasing use of this method during the past decades has provided a rapidly expanding market that is intriguing for the industry. As a
The acetabulum doesn't fully cover the femoral head. This can cause problems reaching developmental milestones such as walking. The hip joint is made of soft cartilage that gradually hardens into bone p birth. If the femoral head isn't seated firmly into the acetabulum it will not fully form and will be too shallow.
It could be possible due to your hip replacement surgery first you consult with your doctor. There are some home treatment using those you can try to reduce the pain but diagnosis of actual cause is necessary. You can try Yoga exercises for pain relief. Some of the most effective Yoga exercise types include Janusandhi, Gomukhasana and Uttanpadasana. These are meant for the thigh and legs pain. You also can use elastic bands in the case of muscle pulls. This reduces the swelling and muscle strains.Manipulation, massage and stretching exercises sometimes help. Plz check with doctor for Meralgia paraesthetica is a nerve (neurological) condition that causes pain in the outer
People undergo total knee replacement when arthritis or injury erodes the joint's natural cushioning to the point where it's hard to walk even short distances without severe pain.
"The term hippotherapy means treatment with the help and use of a horse." (Meregillano) Hippotherapy uses the movement of the horse to challenge the client. With that being said within this following paper is it going to go into more depth about hippotherapy. Not only is it going to go into depth about hippotherapy, but also how the study of hippotherapy works, how it helps people, how it is used, the benefits, and the type of individuals that are needed to perform hippotherapy.
Orthognathic reconstructive surgery is a procedure carried out by a oral and maxillofacial surgeon to correct problems with the jaw. The surgery takes place in a hospital and involves the straightening and realigning of the jaws. Templates, screws, wires, and surgical plates may be used to accomplish this goal. Why would a person need this type of surgery and what should one expect when they opt for this treatment option?