Assessment Of Acute Phase Protein

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Assessment of acute phase protein (plasminogen activating inhibitor) levels and in type 2 Sudanese diabetic patients

A research proposal for master degree of medical biochemistry

By Khalid M.Elhassan Osman Abdelsamad Supervisor Dr. Khalid Hussein

Introduction and literature review: Diabetes mellitus is a metabolic disorder of multiple etiologies. It is characterized by chronic hyperglycemia together with disturbances of carbohydrate, fat and protein metabolism resulting from defects of insulin secretion, insulin action or both.(1) Type 2 diabetes (formerly called non-insulin-dependent or adult onset diabetes) is caused by the body’s ineffective use of insulin. It often results from excess body weight and physical inactivity. The expected number of diabetic patients 438 million by 2030, an increase of 54% compared to predicted figures for 2010(2). Macro vascular diseases such as coronary artery disease are one of complications of both type 1 and type 2 diabetes mellitus. The prevalence of diabetes is increasing, now diabetes also affects adolescents and younger adults, thus promoting the earlier development of long term cardiovascular complications. Diabetes itself accounts for 75 – 90% of the excess coronary artery disease (CAD) risk and enhances the effects of other cardiovascular risk factors. Death from stroke and myocardial infarction (MI) are the leading
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