Asthma Analysis

Decent Essays
Asthma is a heterogeneous disorder characterized by acute episodic exacerbations against a background of chronic persistent inflammation associated with structural changes that may produce persistent symptoms and impaired pulmonary function (Martinez, 2011).
Asthma severity and asthma control are different terms but related pathogenesis. Asthma severity describes the underlying disease process in absence of concurrent treatment to determine the initial step of therapy. Asthma control describes the clinical status of disease in response to interventions. However, the individual parameters which determine asthma severity and asthma control overlap significantly (Yawn et al, 2006).
Assessment of asthma control has become a key element in asthma management. Asthma control is assessed from two domains: symptom control and risk factors. Pulmonary function is an important measure of asthma control and future risk and can be used as a monitoring tool in children. According to the level of asthma control, patients are categorized into well-controlled, partly
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Asthma treatment has been adjusted mainly on the basis of symptoms and pulmonary function. Biomarker can be used to monitor the response to treatments, optimize corticosteroid dose and act as prognostics for exacerbation risk and longer term asthma outcomes (Brisk, 2016)
Airway inflammation and tissue injury with subsequent abnormal repair may lead to structural changes in the airway of asthmatic subjects that defined as airway remodeling. Airway remodeling contributes to irreversible airflow obstruction and airway hyperresponsiveness, and it has been associated with increased disease severity and impaired pulmonary function. [5] Reversal of remodeling gain therapeutic importance, and mechanisms responsible for airway remodeling has become an important target for asthma treatment (Shifren,
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