Atherosclerosis is a multiple factorial disease, which is the major underlying cause of various

800 WordsApr 23, 20194 Pages
Atherosclerosis is a multiple factorial disease, which is the major underlying cause of various cardiovascular diseases including CAD, ischemic gangrene, abdominal aortic aneurysms, heart failure and stroke (Hansson et al., 2006). Worldwide it is the leading cause of morbidity and mortality, especially in developing countries where it is acting as a silent killer (WHO, 2005; Hansson et al., 2013). It was observed that Asian Indians have early onset of the disease as compare to whites, with present burden of 29.8 million people with coronary heart disease (Gupta, 2005; Yusuf et al., 2004). Extensive evidence in the literature supports the role of systematic and chronic inflammation in the pathophysiology of the disease since its inception…show more content…
Ayurveda, an old traditional form of medical practice in India, has produced many effective leads and contributed well for isolation and development of novel therapeutic compounds. Presently, it is estimated that in both developing and developed countries; about 70-80 percent of the world’s population is using alternative medicines for their primary health (WHO, 2008; Pandey et al., 2013). Recently, there is a reborn interest in the use of ayurvedic or traditional medicines for the prevention and treatment of several diseases. Although, number of medicinal plants has been described in “Atharva Veda”, a limited number of plant products are currently in clinical use by western medicine system to treat coronary artery disease (Dwivedi & Chaturvedi, 2000; Mahmood et al., 2010). Polyphenolic components isolated from such plants can delay the onset of the disease through modification of risk factors as well as suppression of oxidative stress and inflammatory response to fight against the disease (Gillespie & Gavins, 2013). Among several medicinal plants, one of the medicinal plants indigenous to Asia, that has shown the most encouraging and marked results as cardioprotective agent is Terminalia arjuna (Roxb.) Wight & Arn., popularly known as Arjuna. Traditionally, the bark extract T.arjuna has been well known for its beneficial effects in angina i.e., “hritshool” and other cardiac ailments (Dwivedi, 2007).

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