preview

Atopic Dermatitis Research Paper

Decent Essays

Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease characterized by pruritus and inflammation and accompanied by cutaneous physiological dysfunction with majority of patients having a personal or family history of “atopic diathesis”. The term Atopic Diathesis refers to the presence of allergic rhinitis, bronchial asthma or AD.1The first recorded reference to Hippocrates described a condition characterized as ‘itching’ over patient’s whole body ,over 2500 years ago.2 The concept of “atopy” (derived from the Greek atopia, meaning “different” or “out of place”) was originally proposed in 1923 and included asthma and allergic rhinitis, but in 1933, AD was added to the group of atopic disorders on the basis of association of …show more content…

Its pathogenesis may include disrupted epidermal barrier function, immune dysregulation, and IgE-mediated sensitization to food and environmental allergens. The centre point of research on the mechanisms of AD has been the adaptive immune system with an emphasis on the T-helper 1 (Th1)-Th2 paradigm. Recently, the conceptual focus has largely shifted to include a primary defect in the epithelial barrier as an initial event in AD, pointing to a complex secondary interplay of environmental and immunological squeal with barrier disruption.5 Various evidences suggests that AD is a cutaneous manifestation of a systemic disorder that also gives rise to other atopic conditions therefore optimal management of AD requires a multifaceted approach aimed at healing and protecting the skin barrier and addressing complex immunopathogenesis of this …show more content…

Decrease in incidence of rickets after fortification of foods with vitamin D led physicians to believe that vitamin D related health disorders had come to an end. But unfortunately, rickets appears to be a mere drop in the vast ocean of disorders resulting from vitamin D deficiency. Vitamin D has potential to suppress inflammatory responses, enhance antimicrobial peptide activity .It also maintains the integrity of the permeability barrier and can stimulate or inhibit keratinocyte differentiation and stimulate synthesis of proteins such as filaggrin that are necessary for formation of the stratum corneum barrier.8 Vitamin D plays a role in atopic dermatitis pathogenesis mainly through its immunomodulatory action.9 Vitamin D active form i.e. vitamin D [1,25(OH)2D3] plays main role in enhancing the expression of antibacterial peptides and thus preventing skin infection

Get Access