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Auditory Dysfunction

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Autism spectrum disorder (ASD) comprises a continuum of neurodevelopmental disorders clinically characterized by social difficulties, impaired communication skills and repetitive behavioral patterns. Despite the prevalence of ASD, the neurobiology of this disorder is poorly understood. However, abnormalities in neuronal morphology, cell number and connectivity have been described throughout the autistic brain. Further, there is ample evidence that auditory dysfunction is a common feature of ASD.(1) The majority of individuals with ASD demonstrate some degree of auditory dysfunction. The level and expression of this dysfunction ranges from deafness and increased thresholds to hyperacusis and difficulty listening with background noise and impairments …show more content…

In the real-world listening situations, auditory information is processed by two ears, often in the presence of background noise.(4) Binaural interaction is reflected in electrophysiological activity of neurons activated by binaural stimulation central to the cochlear nucleus. Binaural interaction is known to occur at three levels of the brainstem: superior olivary complex (SOC), lateral lemniscus and inferior colliculus (IC).(5) Binaural interaction component (BIC) manifests binaural interaction and is valid and proven response which reflects ongoing binaural processing. A BIC in ABR is defined as the difference between the binaurally evoked ABR waveform and a predicted binaural waveform created by algebraically summing the left and right monaurally evoked ABRs at amplitude of waves IV-V.(6, 7) There is a significant correlation between the amplitude of the BIC and the ability to lateralize a sound image as a function of interaural time differences (ITDs) and interaural level differences (ILDs). In addition to the dependence of BIC amplitude on stimulus lateralization, BIC presence is also an indicator of binaural stimulus fusion. Together, this suggests that the BIC reflects the spatial processing of sound in the horizontal plane in the

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