Aversive Effects of Ethanol in Adolescent vs. Adult Rats

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Researchers Nicole L. Schramm-Sapyta, Alexandra

DiFeliceantonio, and Cynthia M. Kuhn (2010), conducted

the study of 'Aversive Effects of Ethanol in

Adolescent vs. Adult Rats', looking to address two key

questions: Number one, do reduced aversive effects of

ethanol in younger rats correlate with increased

ethanol consumption? and second, are the reduced

aversive effects in adolescents attributable to

reduced sensitivity to ethanol's physiological


A sample of adolescent and adult male CD rats (outbred

Sprague-Dawley derived strain) were obtained from

Charles River Laboratories (Raleigh, NC), and

maintained in a temperature vivarium standard of 12:12

light-dark cycle throughout the experiement. Before

the experiment could begin, it was vital to find out

which of the 94 rats formed a conditioned taste for

ethanol, this was achieved with aversion therapy

whereby the rats were deprived of water for 24 hours,

and then given 15 minute acccess to a water bottle the

next day, this was then repeated but the water was

replaced with 0.2% saccharin solution and also

injected with ethanol. After another water deprived 24

hours, the rats had access to two bottles, one

containing water and the other with 0.2% saccharin

solution. The dependent measure was the percent of

saccharin consumption on the test day thus the rats

that consumed less than 1ml of total solution were

excluded from the experiemnt, leaving the researchers

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