Essay on Avian Influenza: The H5N1 Virus

636 Words 3 Pages
Avian influenza has been the prime focus owing to its importance in human health and the economic losses it creates. Asian countries have been mainly affected by the H5N1 virus where the disease is enzootic. A loss of 0.4% change in GDP occurred in South Asian region due to Avian influenza outbreaks (World Bank, 2006). The current control strategies against Avian Influenza are stamping and vaccination. Both these policies suffer from various drawbacks. The stamping out policy leads to loss of genotype, which will results in selection of low disease resistance birds and selection of high virulent virus. Stamping out policy disrupts the dynamics of host-pathogen interactions (Shim and Galvani 2009). Vaccination may result the …show more content…
Avian influenza has been the prime focus owing to its importance in human health and the economic losses it creates. Asian countries have been mainly affected by the H5N1 virus where the disease is enzootic. A loss of 0.4% change in GDP occurred in South Asian region due to Avian influenza outbreaks (World Bank, 2006). The current control strategies against Avian Influenza are stamping and vaccination. Both these policies suffer from various drawbacks. The stamping out policy leads to loss of genotype, which will results in selection of low disease resistance birds and selection of high virulent virus. Stamping out policy disrupts the dynamics of host-pathogen interactions (Shim and Galvani 2009). Vaccination may result the emergence of more virulent variants of the virus. Vaccination also suffers from drawbacks like antigenic drift in field viruses by inactivated vaccines, decreased efficacy when used for a long periods etc. (Ausvetplan 2008). These factors points towards the need for an alternative strategy to control Avian influenza for which a better understanding of the disease process is necessary. Targeting NS1directly would be an option in devising a control strategy against H5N1.
Integrating bioinformatics with gene expression data is an attractive strategy in enabling to propose new therapeutic strategies to combat avian influenza viruses in a very cost effective manner. Very many software’s are currently available in
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