Azacitidine Research Paper

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Azacitidine is a pyrimidine nucleoside analogue of cytidine (Figure 1). Chemotherapy drug used to treat a group of disorders that affect the bone marrow and blood, known as myelodysplastic syndromes (MDS).It is a pro drug. Once inside the cell it is uptaken by human concentrative nucleoside transporters. It is phosphorylated into monophosphate, di and tri phosphate forms. Azacytidine triphosphate is the active form which is incorporated into RNA. Azacytidine is approved for the treatment of adult patients who are not eligible for hematopoietic stem cell transplantation with intermediate-2 and high-risk MDS, chronic myelomonocytic leukemia (CMML) with 10%–29% marrow blasts and without myeloproliferative disorder and AML with 20%–30% blasts and
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