B12 Deficiency What is Vitamin B12 Deficiency Vitamin B12 deficiency limits selenium methylation

The lack of intrinsic factor in the stomach leads to a vitamin B-12 deficiency. Vitamin B-12 is necessary for production of normal, healthy red blood cells. Without B-12, red blood cells become to large(macrocytic) and do not carry enough oxygen to supply the body. Without enough oxygen the body can not function normally and a person is said to be anemic (Pernicious Anemia, n.d.).

How can anyone have a deficiency? Despite advances in vitamin research over the last century, millions of people around the globe still suffer from vitamin deficiency diseases. In the United States, the plentiful and

Other sources of vitamin B₁₂ are dietary supplements, tablets/lozenges, and prescription medications. In dietary supplements the vitamin is the form of cyanocobalamin which the body changes to methylcobalamin and 5-deoxyadenosylcobalamin. The ability to absorb the vitamin through the supplements is restricted due to the volume of the body’s intrinsic factor. Tablets/lozenges are known to have exceptional bioavailability. Prescription medications such as intramuscular injections can come in the form of cyanocobalamin or hydroxocobalamin and is used to treat vitamin B₁₂ deficiencies. Prescription medication can come in a gel form for people who would take it instead of injections and raises B₁₂levels in

Pernicious anemia is the etiology of vitamin B12 deficiency due to the lack of production of an intrinsic factor (IF), altered pH in the small intestine, and lack of absorption of B12 complexes in the terminal ileum as well as folic acid deficiency. Impairment of IF production can occur in adults due to autoimmune destruction of parietal cells, which secrete IF; gastrectomy can significantly reduce the production of IF. A rare congenital autosomal recessive disorder can result in deficiency of IF without gastric atrophy. Other disorders that interfere with the absorption and metabolism of vitamin B12 can produce cobalamin deficiency, with the development of a macrocytic anemia and neurologic complications. Some autoimmune diseases such as Graves' disease, Hashimoto's thyroiditis and vitiligo the depigmentation or blanching of skin areas. (Center Disease Control &Prevention (CDC), 2015)

One of the most vital nutrients for good health is vitamin B12. It comes from animal foods and is responsible for big things such as the synthesis of DNA and the sheath that protects the nerve cells. There are lots of things you could be doing to deplete the essential B12 your body needs, including eating an unhealthy diet, smoking, and drinking, but there are also things like pregnancy and growing older that can be affecting how much B12 your body is getting.

According to a case report published in the French journal, Encephale, patients with vitamin B12 deficiency can show signs of depression, mania, and psychosis.

In 1872 Michael Anton Biermer described a blood condition in a German article. He chose to name the rare disease he discovered “Pernicious anemia” because of the lethality and incurability at the time. Biermer’s disease or Pernicious anemia is a genetic disease where patients’ stomachs do not produce intrinsic factor which is a protein of the mucus membrane layer of the stomach.When the stomach does not make enough intrinsic factor, the intestine cannot properly absorb vitamin B12. The body needs vitamin B12 in order to function properly and remain healthy. Vitamin B12 assists in the production of red blood cells, DNA, and tissues, while helping keep nerve cells alive and healthy.This vitamin is found in many animal products such as beef, poultry, shellfish and more.

Selenium deficiencies have been linked to various illnesses such as depression, a weakened immune system, and infertility in both men and women.

Rates are also higher among mothers with certain health problems, such as diabetes or seizure disorders (taking certain anticonvulsants), and significantly higher among couples in which at least one has SB, and couples who have already had a child with SB.” But, as “The HealthDay News” reporter Robert Preidt noticed: “Serious birth defects of the brain and spine called neural tube defects have fallen 35 percent in the United States since mandatory folic acid fortification of enriched grain products.” Since that moment, 1,300 fewer babies are born annually with neural tube defects. However, the Mayo Clinic Staff point out that doctors and researchers do not know for why SB occurs, they have identified few risk factors: race, some medications, and family history of neural tube defects which are defined early in the paragraph. Also, sex, folate deficiency, diabetes, obesity, and increased body temperature can be considered as risk factors of developing SB. First is sex, girls are effected more often. Second, folate (vitamin B-9) is important to the health development of a baby. The systemic form, found in supplements and fortified foods, is called folic acid. “The Genetics Home Reference” noticed that the gene called MTHFR (methylenetetrahydrofolate reductase) provides instructions for making a protein that is involved in processing the folate, and shortage (deficiency) of this vitamin

Pernicious anemia is a condition in which the body fails to make enough healthy red blood cells because there is a deficiency of vitamin B12. Vitamin B12 is a nutrient that the body needs in order to make healthy red blood cells and to keep the nervous system working properly. Individuals with pernicious anemia can’t absorb enough vitamin B12 from foods because they lack intrinsic factor (IF), a protein made in the stomach that is necessary for the absorption of vitamin B12. A lack of this protein leads to a deficiency of vitamin B12. ( ) The decreased absorption of vitamin B12 from the gastrointestinal tract that causes this condition is believed to be the result of an autoimmune process which makes the body’s immune system attack the lining of the stomach. Normally, vitamin B12 binds to intrinsic factor in the stomach to help ease its absorption later when digestive products pass through the small intestines. The autoimmune process attacks the IF protein resulting in lower IF levels in stomach secretions, therefore, causing vitamin B12 to not be absorbed. ( )

Vitamin B12 shots have been a mainstream treatment for patients lacking in this vitamin. Intense destructive impacts of vitamin B12 lack can be disposed of or modified through vitamin B12 shots. An inclination for utilizing these shots is because of poor assimilation abilities of oral dosages when taken in huge

Some of the client education for this type of anemia would be dependent upon the reason for the deficiency. Education would be needed on options for dietary replacement of this vitamin. A list of foods high in B12 should be given, also clear instructions on dosage and self-administration of oral B12 supplements. Medications to avoid should also be included in education. Risks associated with not replacing B12 should be discussed. The patient should be educated on possible side effects and also symptoms of

I noted deficiencies in a number of vitamins in the January study. Calcium was only 0% of target levels, and potassium was well less than half of target levels. My sodium count was with the acceptable range, but just barely. I had deficiencies of iron, copper, and magnesium, but did acquire my recommended intake of phosphorous, selenium and zinc. I fell short on Vitamin A, Vitamin C, E, K, and

Vitrition Selenium is a nutrient that naturally occurs in trace amounts, but is vitally important to the human body. It has been shown to help prevent cancer, heart disease, dementia and thyroid disease, while low levels of the nutrient have been found in people with HIV and Crohn’s Disease. What makes selenium so beneficial is that it activates a powerful antioxidant within the body called glutathione, which does everything from remove toxins from the body to strengthen the immune system. Due to its potency, you only need one Vitrition capsule a day to reap the benefits of this powerful

Several studies have found an association between an elevated serum vitamin B12 level and cancer. Chiche et al (2008) found solid neoplasia in 23% and malignant hematologic disorders in 23% of subjects with elevated vitamin B12. The presence of malignant hemopathy was associated with an elevated vitamin B12 level. Researchers found a vitamin B12 level above 1275pg/mL in 80% of subjects with malignant hemopathies (p<0.05). (chiche 2008) Deneuville et al found a vitamin B12 above 820pg/mL was associated with cancer (OR 1.8, 95% CI 1.2-2.6), malignant hemopathies (OR 2.1, 95% CI 1.3-3.5), metastasis (OR 2.9, 95% CI 1.5-5.9), liver metastases (OR 6.2, 95% CI 2.7-14.5), hepatocellular carcinoma (OR 3.3, 95% CI 1.1-10.4), and lymphoma (OR 3.2,