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Barter Syndrome Research Paper

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Batter syndrome is inherited autosomal recessive thick ascending loop disorder that is characterized by following clinical features: • metabolic alkalosis • hyperreninemia • hyperaldosteronism • hypokalemia (low level of plasma potassium ion) • hypomagnesaemia (high level of excreted magnesium level) • hypocalcaemia (excessive urinary losses of calcium ion) • excess production of prostaglandin E2 (PGE2). Bartter syndrome is divided to two types: neonatal and classic. In case of neonatal Bartter syndrome, it is detected at 24-30 weeks of gestation, and excess of amniotic fluid. After birth, infant will urinate and drink excessively, and too much excretion of calcium ion might lead to formation of kidney stone. Meanwhile, classic Bartter syndrome is usually diagnosed at childhood and patients will have same syndromes as in case of neonatal Bartter syndrome. Difference is that, urinary calcium excretion is not too much and do not have tendency to to form kidney stones. In addition patents might have low blood pressure, excessive thirst (polydipsia), excessive urination (polyuria), which might lead to dehydration. Other symptoms include constipation, vomiting, and because of inability to retain sodium, magnesium and calcium ions, there might be muscle weakness, cramping and fatigue.…show more content…
Na+ , K+ and Cl- cotransporter is envolved in electroneutral transport at apical surface, which is driven by low concentration of these ions. This low concentration of ions is achieved by basolateral Na+ and K+ contertransporter (sodium-potassium adenosine triphosphatase) and basolateral chloride ion channel by facilitated diffusion (CLC-kb). Potassium ion is capable of diffusing back to lumen through apical potassium channel (ROMK) and returns net positive charge to lumen, this is important for reabsorption of calcium and magnesium
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