Baycol Research Paper

Decent Essays
Baycol is a drug containing 0.2, 0.3, 0.4 or 0.8 mg of the active ingredient cerivastatin sodium and inactive ingredients: mannitol, magnesium stearate, sodium hydroxide, crospovidone, povidone, iron oxide yellow, methylhydroxypropylcellulose, polyethylene glycol, and titanium dioxide. Cerivastatin sodium is sodium (C26H33FNO5Na) with molecular weight of 481.5 and the following chemical structure:

Clinical Pharmacology
Baycol is a drug that was used to reduce cardiovascular diseases created by the pharmaceutical company Bayer. This drug is part of the class of statins. This class of drugs reduces the cholesterol level in the blood decreased cholesterol production by liver shutting down the enzyme responsible for its production. The enzyme is called hydroxy-methylglutaryl-coenzyme A reductase
…show more content…
The studies have incorporated more than 5,000 patients with Type IIa and IIb hypercholesterolemia treated in trials periods of 4 to 104 weeks.

Patents and Trademarks
FDA approved the application of Baycol in June 26, 1997, after a period of 2,262 days for applicable regulatory review. The testing phase occurred during 1,896 days, while the approval phase occurred in 366 days.
Baycol was marketed by Bayer A.G. until 2001, competing with Pfizer's highly successful atorvastatin (Lipitor). Voluntarily in 2001 Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis.

Post- market
During the practice of monitoring the safety of Baycol (postmarketing surveillance), 52 deaths and 385 nonfatal cases were reported in patients using cerivastatin due rhabdomyolysis. The cerivastatin caused 16 to 80 times more deaths than other statins. In 2002, over 100 deaths were reported due
Get Access