Benefits Of Clostridium Difficile

Clostridium difficile associated disease will resolve when the patient discontinues taking the antibiotics to which he/she has been previously exposed (Nipa, 2010). Administration of a different antibiotic is used to treat the infection (Grossman, 2010). The infection can usually be treated with an appropriate course of about 10 days of antibiotics including metronidazole or vancomycin administered orally (Nipa, 2010). On occasion intravenous vancomycin may be necessary (Gould, 2010). The nurse should ensure patients are not only taking the newly prescribed antibiotic, but also responding to the treatment by showing a decrease in symptoms. Symptoms can recur despite antibiotic therapy, close monitoring is essential. In order to avoid risk of further complications, nursing interventions would include careful assessment of white blood cell count, temperature, and hydration status; meticulous skin care and assistance with bowel elimination given the loose frequent stools; and management of abdominal discomfort (Grossman, 2010).

Many Americans die each year from complications connected to Clostridium difficile. It can ill a significant number of individuals as well as animals. The Clostridium difficile infection is the result of poor hygiene, misuse, overuse of antibiotics and an aging population. In this paper I will be discussing the following topics, what clostridium difficile means, what it causes, signs and symptoms, complications, treatment and the prevention.

Clostridium difficile is a gram-positive, spore-forming, anaerobic bacillus. Since the turn of the 21st century, there has been a dramatic increase in the number of nosocomial infections associated with antibiotic exposure and an increase in the severity of the disease. Challenges of disease containment include emerging risk factors and recurrence. In 2008 the acute care costs, not including the economic burden placed outside of the hospital, was estimated to be around $4.8 billion in the US. As such, it has become clear that preventative measures are needed to monitor and reduce the risk of infection and recurrence.

Clostridium difficile involves a gram-positive spore-forming bacterium, which is a normal element of the colon flora in people. The Clostridium difficile can cause antibiotic-associated diarrhea when the competing bacteria in the gut flora are all killed by antibiotic treatment. The Clostridium difficile infection is one of the serious healthcare-related infection and also a rising health care problem. In the early 1970s, the Clostridium difficile has been known to have the ability to cause pseudomembranous colitis. As stated, the infection is the most cause of nosocomial infectious diarrhea (Aktories & Wilkins, 2000). Individuals that are colonized with clostridium difficile serve as the reservoir for infection and this is by contaminating the environment with spores of such bacteria. This will lead to the spread of the organism on the health care worker’s hands or even through the use of medical equipment. In this paper, we are going to focus on the effective prevention strategies for clostridium difficile. What are the effective prevention strategies for clostridium difficile?

Ingestion of the endospore causes infection. Once it reaches the preferred anaerobic environment of the gut, the endospores germinate and begin releasing toxins A and B (Burns & Minton 2011). The presence of C. difficile does not necessarily mean infection. A patient can be positive for C. difficile but have normal stool, which means there is colonization without infection. Patients who have the C. difficile pathogen without experiencing any symptoms allow it to be passed along undetected which contributes to the ongoing spread to others. Only when toxin A and toxin B are released at suitable levels does C. difficile become pathogenic to humans. Once infected, typical symptoms include watery diarrhea, abdominal pain, colitis, fever, and fecal leukocytes. Moderate to severe Clostridium difficile infection (CDI) consist of profuse diarrhea, abdominal distention, leukocytosis, systemic inflammatory response, pseudomembranous colitis, megacolon and death (Sunenshine & McDonald, 2006). With the combination of a highly resilient endospores, and asymptomatic carriers, this allows C. difficile to persist in the environment and spread to patients with compromised immune systems, or older patients who have a high risk of contracting CDI with a higher severity than healthy adults (Laffan, Bellantoni, Greenough, Zenilman, 2006).

CDI cannot be treated with many antibiotics, and as early as 2000 another strain appeared that was resistant to even more antibiotics, including fluoroquinolones (“Antibiotic/Antimicrobial Resistance.”). This new strain creates more toxins and can show up in people not normally considered at risk for CDI infection, like those who have not been hospitalized or treated with antibiotics (“C. difficile infection.”). This aggressive strain only adds more danger to an already resistant bacteria. As antibiotics became more common, they were prescribed for thousands of common illnesses. Over time, Clostridium difficile has built up a resistance to antibiotics to become a major concern. Even more frightening, it has started to appear in the community. In fact, the Centers for Disease Control rate it as an urgent threat. Superbugs like CDI are becoming a more ever-present threat and we must continually work towards newer and more effective treatments to counteract the bacterias frightening ability to resist us (“Antibiotic/Antimicrobial Resistance.”). CDI is just one of many superbugs, however, and others pose just as great a

In the article, Poop Pills Sound Gross, but Cure Serious Gut Infections, by Associated Press, doctors have found a way to put healthy people's poop into pills-and these pills are now being used to cure serious gut infections. In the article it states that, “Half a million Americans get Clostridium difficile, or C-diff, infections and about 14,000 die.” This was when poop pills were not invented yet and they had treatments that were very uncomfortable and very pricy. They did get rid off the bad bacteria in that area, but it destroyed the healthy, good bacteria and could cause reinfections of C-diff. C-diff is an infection in our bodies that gives us issues when we go to the bathroom. The, one time treatment created by Dr. Thomas Louie

These single celled tube-like organism finds a home in the gut of every human during their lifetime. If the person affected does not have the proper bacterial flora to balance Clostridium difficle, the bacteria will manifest itself. The bacteria produces a toxin that breaks down the outer and inner linings of the small and large intestine causing the condition, Clostridium difficle Colitis. The impaired intestine will cause the body to have up to 20 bowel movements a day. The bowel matter will eventually turn to water and blood, causing extreme malnourishment and dehydration. The bacterial infection, if not intervened will cause morbidity. According to Roos (2015), the CDC reported there are half- million cases and thirty-thousand deaths each year in the United States. Clostridium difficle is one of the world’s leading causes of deaths in assisted living facilities (Roos,

Each year in the United States, many people require hospitalization due to various medical reasons. Often times, patients must undergo a course of antibiotics to treat the medical condition that warranted the hospitalization. The combination of the necessity to be admitted to a health care facility along with the administration of an antibiotic may result in a Clostridium difficile infection (CDI). The purpose of this paper is to provide an overview of a CDI, including an overview of the microbiology of Clostridium Difficile (C- diff), as well as the epidemiology, pathophysiology, signs, symptoms, treatment and prevention of the infection.

Clostridium difficile or otherwise known as C.diff. is a life threating infection that can cause a wide range of symptoms. Patients can experience anything from diarrhea to inflammation of the colon that can lead to death. In the past few years, Clostridium difficile infection rates have increased here in the United States causing great concern about the effectiveness of current treatments. For the past fifty years, the medical community has been investigating other areas for better treatment options.

Clostridium difficile is a gut infection that infects 500,000 americans yearly and get around 14,000 of the infected people die from the infection. Treatment for it costs a lot and is uncomfortable. Dr.Thomas Louie has created a cheap and more comfortable alternative known as “poop pills.” It's not really feces just stool bugs. They take the poop/stool/feces from donors, take out the stool bugs, clean and sterilize them, while keeping them alive. Then they tripple coated in a gel coating. A couple days before the treatment, patients take antibiotics to kill the bacteria and have fresh, infectious bacteria that haven’t done anything yet. The day of the treatment people down 24-34 pills all in one sitting. Dr. Louie has tested

Clostridium difficile infection (CDI) is the most common cause of antibiotic associated diarrhea (AAD). Rapid diagnosis of CDI is essential to prevent hospital spread of infection. The aims were to determine the prevalence of CDI among cases of AAD in Zagazig University Hospitals, identify risk factors, and evaluate real-time polymerase chain reaction (PCR) and enzyme immunoassay (EIA), against toxigenic culture (TC). Stools were collected from 150 patients with AAD. They were tested for TC, toxin A/B EIA, and C. difficile tcdA/tcdB genes. Thirty four toxigenic C. difficile isolates were obtained (22.7%) out of the 150 patients and those patients were considered positive for CDI. On the other hand, 6 non-toxigenic C. difficile isolates were obtained (4%), while culture of the remaining 110 patients (73.3%) did not yield C. difficile. The later 116 patients (77.3%) were considered negative for CDI. Analysis of risk factors revealed that advanced age, prolonged hospitalization, long duration of antibiotic intake, potentiated penicillins, 3rd generation cephalosporins, antibiotic combined therapy, liver cirrhosis, malignancy, proton pump inhibitors, enteral tube feeding, and cancer chemotherapy were significantly associated with CDI. Sensitivitiy, specificitiy, positive predictive value, negative predictive value, and accuracy of real-time PCR against TC were all 100%, however, values of EIA were 79.4%, 100%, 100%, 94.3%, 95.3%, respectively. Conclusion: CDI is an

More than 14,000 people die every year from an infectious disease called Clostridium Difficile, or C-Diff. This is a germ that causes severe cramping, nausea, and diarrhea. But now doctors have found a way to cure people with this infection. The doctors give you 24 to 34 pills to swallow in one sitting. These pills aren’t anything regular though, they are triple-layered capsules filled with a healthy person's stool. There isn’t really any poop in the pill, but just the good bacteria which helps to cure you of C-Diff. This treatment is more successful at curing people of this disease. You can buy very expensive treatments that won’t cure you. So in conclusion, poop pills may not sound amazing, they can really help your gut if you need it.

“Recurrent C. difficile infection is defined as an episode of C. difficile that occurs 8 weeks or less after the onset of an initial episode of CDI that resolved with or without therapy.” (Gerding et al. 1986) Patients present with a variety of clinical findings ranging from an asymptomatic carrier state to the development of mild to moderate non bloody diarrhea. Typically, individuals experience the common symptoms like abdominal pain, malaise, nausea, vomiting, dehydration, and fever.

Doctors have discovered how to have healthy people’s poop be transformed into pills that can be used to cure dangerous gut infections. Every year half of a million people get C-diff every year and around 14,000 die. Fecal transplants can restore bacteria caused from C-diff and also stop it from coming back. The problem with fecal transplants is that they cost a ton and they’re very painful. The new way of “poop pills” makes patients swallow around “24-34 pills” which is around enough pills to hold enough bacteria for the cure. People have said things about C-diff such “I felt like I was dying.” Overall C-diff is very dangerous so it’s good that we found a cure.