preview

Benefits Of The Low Back Pain Condition

Decent Essays
The low back pain condition is becoming more frequent in industrialized countries. The treatment of this condition is effective using peripherally acting NSAIDs justly in a short-term relief or in acute low back pain.1 At the same time, the use of antidepressants or other drugs such as tramadol have shown efficacy, where tramadol is centrally acting analgesic by inhibiting serotonin and noradrenaline reuptake, and activating nonselective m-opioid receptors via its active metabolite. 1 Moreover, acetaminophen is considered a first-line treatment for chronic pain and commonly used among several years, which effectiveness is due to its analgesic and antipyretic properties. 1 However, acetaminophen may present some hepatotoxic effects when misused.1 Therefore, the concomitant use of both therapies would bring efficacy with a multiple analgesic mechanism of action, since this therapy also shown a synergistic effect in animal models. 1
According to Lee (2013), it would be more effective an extended-release release tramadol HCl 75-mg/acetaminophen 650-mg fixed-combination tablets (TA-ER) formulation to achieve pain relief effects in a sustained analgesic activity over time. 1
Therefore, the objective of this study was to evaluate the efficacy and safety of TA-ER, in a Phase III clinical trial, for the treatment of moderate to severe chronic low back pain insufficiently controlled by previous NSAIDs or cyclooxygenase-2 (COX-2)–selective inhibitors. Hence, they conducted the study in
Get Access