Benzedrine Research

Xanax is a benzodiazepine that is most often used to treat anxiety. The effects of benzodiazepines mainly come from their ability to alter the movement of the inhibitory transmitter known as GABAa. GABA is triggered to release when it then can bind to the GABAa receptor. The binding of the two causes the ion channel to open and chloride ions are sent across the cell membrane. This causes the inhibitory factor by depolarizing the membrane (Griffin et al., 2013).

In this lab, liquid-liquid extraction was performed to isolate a mixture of benzocaine and benzoic acid. 2.0107 grams of the mixture was first weighed out for the trials. When HCl was added to the mixture for the first acid extraction of benzocaine, an emulsion formed during inversion and venting that prevented a defined separation of the two layers. 8 mL of water was therefore added before continuing the extraction. The addition of NaOH then turned the top aqueous layer basic, indicated by the pH strips that turned blue when tested. A vacuum filtration isolated 0.29 grams of benzocaine and a MelTemp apparatus measured the crystal’s melting point ranges to be 85.1C-87.4C. For the base extraction of benzoic acid, the aqueous layers were retrieved

It wasn’t until the mid-1800s that a PhD student in Germany created an isolated cocaine alkaloid that would be used as the first anesthetic. Albert Niemann, the student who perfected cocaine purification process, noted many properties of drug. One journal esteemed its bitter taste and temporary numbness the pharmaceutical caused. By the late 1800s, the drug’s known applications became increasingly popular. Cocaine became the go-to cure for everything from epidurals to tooth aches. When combined with alcohol, the resulting cocaethylene generated a potent concoction with potent effects, making cocaine

In a society where quantity of work overpowers quality of work, there is no wonder why "neuroenhancing" drugs such as Adderall and Ritalin are on the rise of consumption. As more people adopt the idea that these drugs are cognitively beneficial; the more they secretly use them for non-medical reasons. Margaret Talbot, a writer for The New Yorker, looks more into this problem in her article, "From Brain Gain: The Underground World of "Neuroenhancing" Drugs". Throughout this article Talbot focuses on a new trend of drug use, such as Adderall and Ritalin, for non-medical intentions. She focuses mainly on the increase of drug use by scholars and public intellectuals throughout her article. Talbot successfully proves to her audience that non-medical

Samples of benzophenone, malonic acid, and biphenyl were each tested with water, methyl alcohol, and hexane. Benzophenone was insoluble in water as it is nonpolar while water is highly polar. Benzophenone was soluble in methyl alcohol, dissolving in 15 seconds, because methyl alcohol is intermediately polar as benzophenone is nonpolar. Methyl alcohol is polar but not as much as water. Thus, the nonpolar benzophenone was soluble in methyl alcohol. Benzophenone was partially soluble in hexane because hexane is nonpolar as is benzophenone. Thus, benzophenone was dissolved in hexane. Malonic acid was soluble in water because both malonic acid and water are polar. It took 25 seconds for malonic acid to dissolve in water. Malonic acid was soluble in methyl alcohol because malonic acid is polar and methyl alcohol is intermediately polar, allowing malonic acid to dissolve in the methanol in 15 seconds. Malonic acid was insoluble in hexane because hexane is nonpolar while malonic acid is polar. Biphenyl was insoluble in water as water is highly polar whilst biphenyl is nonpolar. Biphenyl was partially soluble in methanol which is intermediately polar whilst biphenyl is nonpolar, allowing it to dissolve a little. Biphenyl was soluble in hexane because both biphenyl and hexane are nonpolar molecules. Biphenyl dissolved in hexane in 10 seconds.

In order to isolate benzoic acid, benzocaine and 9-fluorenone, each component needed to be separated from one another. All three compounds began together in one culture tube, dissolved in methylene chloride and formed into a homogenous mixture. In this culture tube, two milliliters of aqueous three molar hydrochloric acid was added, which immediately formed two layers, the top acidic aqueous layer was clear in color and contained benzocaine, and the bottom organic formed was yellow and contained benzoic acid and 9-fluorenone. Benzocaine’s amino group is protonated by the aqueous layer hydronium. This protonation forms the conjugate acid of benzocaine, benzocaine hydrochloride. Thus, the conjugate acid, benzocaine hydrochloride is a salt in which is soluble in water and furthermore can be isolated from the organic mixture. When testing out the pH levels in benzocaine, the pH test strip was dark blue in color, indicating a pH level of around 5 to 7. When isolating benzoic acid, two milliliters of aqueous three molar sodium hydroxide was added, which deprotonates the carboxylic group in benzoic acid, forming its conjugate base, sodium benzoate. As with benzocaine hydrochloride, sodium benzoate is a water soluble ionic salt in the aqueous layer that can then be separated from the bottom organic layer containing the 9-fluorenone. The pH test strip was a vibrant red for benzoic acid, indicating a pH of 2. Now the 9-fluorenone is left, deionized water is added to remove any excess

Mothers and nurses were giving children heroin-filled soothing syrups to treat a cold, or simply to “soothe” them to sleep. The journalist said, “the systematic doping of the delicate organisms of infants with these subtle and powerful drugs [was] practiced everywhere remorselessly or in desperate ignorance of its consequences.” The involvement of innocent children in the drug problem evokes a sense of urgency; however, the article does not just appeal to the reader’s emotions. Rather it is substantive, providing insight about what was happening in politics and medicine at the time. There was an attempt to investigate and try to regulate the medical use of opiates and other questionable drugs. The author cited an investigation by the Division of Drugs in the Bureau of Chemistry that found that soothing syrups often contained drugs such as powdered opium, chloroform, codeine, and cannabis, in combination or in place of heroin. It also referenced the action taken by pharmacists in Philadelphia to only sell these habit-forming “remedies” with a doctor’s approval or prescription. When looking at this article in a broad sense, one can see the change in mindset by medical authorities--which only ten years prior saw heroin as a great innovation in medicine.

When concerned with the ethics of development in a global environment, the issue of drug abuse is of particular importance. All of the different aspects of the drug trade impact a nation, and specifically the development of a nation within a global environment. Within the United States, drug abuse has been prevalent among specific populations in society for almost a half of a century now. Historically speaking, drug abuse has erupted in many directions; new drugs have offered new markets, new trends have developed new habits. These patterns have become societal concerns on many levels. The creation of new drugs has added another dimension to prescriptive drug abuse. Though science is making

In “The Army Disease: Drug Addiction and the Civil War” written by Johnathan Lewy, he has concluded that the Civil War and the use of hypodermic syringes were the foundation of what led to the events of 21st century drug addiction, as well as one of the first events for the current mass drug addiction in America.

The earliest form of painkillers was first created in the 16th century where people used laudanum or opium prepared in alcoholic solution as pain relivers. In the early 19th century, people extracted morphine from old opium poppy plants and this form of painkiller was most commonly used in the American Civil War. As Morphine was found to be very addictive, chemists in the 1870s produced heroin that did not turn out to be a success as it was proved to be more addictive than morphine. Many other synthetic opiates such as Vicodin, OxyContin, Percocet were produced respectively in 1984, 1995 and 1999. However, these synthetic opiates could only be given if prescribed by a doctor as they could also be addictive. There were also other options of

Amphetamine was first marketed in the 1930’s under a different name (Dexamyl) as an over-the-counter inhaler to treat nasal congestion.2 By 1937, amphetamine was available by prescription. During World War II, amphetamine was widely used to keep soldiers operative.3 Now spreading fast into mainstream culture, meth was originally used by bikers and truckers to stay awake on long journeys.4

While these two drugs have had such a great impact on our world, there are many other drugs that were very important during World War Two. Sulfanilamide, for example, was carried by soldiers all the time. It was a white powder, sprinkled on wounds to prevent infection, and it still exists today! The mortality rate of wounds without Sulfanilamide was 75 per 100 people, however, with Sulfanilamide, the death rate plummeted to 11 per 100 people! Morphine was also greatly used during the war because of its strong painkilling properties. However, it was extremely addictive, it was even more addictive than Nicotine (one of the most addictive substances known to man)! It was originally made from poppy plants indigenous to Turkey and India, and it was administered through a syrette. A syrette is a small auto-injector with a tube attached similar to a tube of toothpaste, but much smaller. Morphine caused many people to faint if they were fatigued or severely wounded, proving the extreme strength of the drug.

Meth was based off the German-made amphetamine. Later in 1919, the Japanese found out methamphetamine was easier to make and more potent. It was used with both sides of World War II as an injection to keeps troops awake for things like suicide missions with Kamikaze suicide pilots. After the war though, it became available to the public in Japan.

Drugs have been around for thousands of years. "A drug is any chemical that produces a therapeutic or non-therapeutic effect in the body (Drugs and Teen Substance Abuse 2000.)" Most drugs were first used for medicinal purposes, such as marijuana. Active substances were not extracted into drugs until the 19th century. Newly discovered substances like morphine, laudanum, and cocaine were completely unregulated and prescribed freely by physicians for a wide variety of ailments. Wounded veterans returned home with their kits of morphine and hypodermic needles (History of Drug Abuse, n.d.) The use of illegal drugs is increasing, especially among young teens. The conflict theory of social problems states that, "society is marked by conflict due

Enhance the affinity of the recognition site for GABA by inducing conformational changes that make GABA binding more efficacious.