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Bestatin Hydrochloride Research Paper

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Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B [1].
Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases. It can be administered to cultured cells, intact animals and humans with low toxicity. It has been used as an useful tool to elucidate the physiological role of some mammalian exopeptidases in the regulation of the immune system, the growth of tumors and their invasion of surrounding tissues, and in the degradation of cellular proteins [2].
In vivo: In a mouse dorsal air sac assay, oral administration of bestatin (100-200 mg/kg/day) significantly inhibited the melanoma cell-induced angiogenesis. Bestatin inhibited the tube-like formation
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