Binding Sites Of Drosophila And Humans

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tor binding sites in Drosophila and Humans

This research paper is about analysis of variation at transcription factor binding sites in Drosophila and humans. This analysis is done in order to investigate the transcription factor binding sites (TFBS) variability with the comparison of ready published data of transcription factor binding maps for Drosophila isogenic lines and human individuals. In this paper, it is very important to understand the concept of population genetics. Population genetics explains the study and research of distributions and modifications of allele frequency in a population. It further states that there are actually four evolutionary processes such as; selection, genetic drift, mutation and gene flow.
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The paper also analysis that, relationship between individuals and interspecies like Drosophila variations expresses an idea and generates an evidence for the reader that, operational buffering of transcription factor binding sites exist both in humans as well as in other living organisms. If the analysis is just done through broader spectrum the results acquired will demonstrate the actual capacity and potential of combing functional genomics and population genetics. In this paper basically, three approaches were used to investigate and find out the TFBS functional constraints based on the variation data that is either ENCODE or other established and published data, those are: Position-by-position comparisons results in the diversity of interspecies at bound motifs and flanks, genome wide properties show that there is no relationship between average motif and 100 kb of Drosophila chromosome and individual motif instances show the general distribution of TFBS load in human and Drosophila.
Based on the above mentioned observations, it can be concluded that the quality and genetic diversity of the DGRP (Drosophila Genetic Reference Panel) has made it suitable for an international analyses of transcription factor binding sector variation. It has also been understood that this information is unlikely to elicit a prohibitive bias and that TFBS are functional constraints and can be tolerated so that, possible buffering effects
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