Biofilm Formation and Colonization are of Prime Importance in Initiation and Progression of Dental Caries

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An ideal restorative material should have a property of adhesion to tooth structure and an ability to withstand the occlusal forces. However, some therapeutic and caries preventing efficacy might be desirable. Glass ionomer cement has been shown to produce some degree of antibacterial effect due to release of fluoride [3]. Several studies have been done to increase the antimicrobial effect of GIC without compromising the physical properties of the restoration. Takahashi Y [4] in 2006 and Tuzuner T [1] in 2011 advocated that the incorporation of chlorhexidine into GICs has resulted in an excellent antibacterial effect in vitro. Frencken JE [5,6] observed that microorganisms counts in both affected and infected dentine were significantly …show more content…
An ideal restorative material should have a property of adhesion to tooth structure and an ability to withstand the occlusal forces. However, some therapeutic and caries preventing efficacy might be desirable. Glass ionomer cement has been shown to produce some degree of antibacterial effect due to release of fluoride [3]. Several studies have been done to increase the antimicrobial effect of GIC without compromising the physical properties of the restoration. Takahashi Y [4] in 2006 and Tuzuner T [1] in 2011 advocated that the incorporation of chlorhexidine into GICs has resulted in an excellent antibacterial effect in vitro. Frencken JE [5,6] observed that microorganisms counts in both affected and infected dentine were significantly lower underneath conventional GIC restorations. It is speculated that the chlorhexidine released from the material can persist in the mouth by binding to the pellicle and saliva, creating a bacteriostatic milieu, which delays bacterial colonization and biofilm formation as observed by Auschill TM et al. [7] in 2005. Lactobacillus has been found to be the most resistant oral microorganism to the inhibitory effects of GIC (Herrera M. et al. 1999) [8]. Botelho et al. [9 ] in their study claimed Cetrimide-GIC combination to be more effective in comparison with Chlorhexidine-GIC combination. Chitosan is a safe and nontoxic material, which is capable of promoting regeneration of oral soft tissue and alveolar bone. It has bactericidal
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