Biosynthesis of Nucleic Acids
Page Break How in the world did the nucleic acid come from and how was it discovered is the question. Well, in 1869 a biochemist by the name Johann Fredrich Miescher (1844-1895) that was Swedish discovered nucleic acids. While biochemist Miescher was looking at cells he saw that there was an odd organic compound in the nucleus. With Miescher seeing this compound he named it nuclein. The organic compound was unique because it had phosphorus and nitrogen in it. Also, the compound had oxygen, carbon and hydrogen also in its makeup. The nuclein compound was the first compound of this type to have those elements. as time progressed and more research was conducted on the compound. It was found that nuclein
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These reactions are very elaborate and complex and thus they both require different enzymes which in case are absent, the defects and deficiencies result to very severe diseases and conditions in animals.
Nucleic acids are seen as very large molecules with the DNA molecules as the largest followed by the RNA. Studies reveal that nucleic acid molecules have sizes that ranges in size from 21 nucleotides which are the smaller RNA to large chromosomes found in human beings which are single molecule which contain about 247 million nitrogenous base pairs. It also revealed that most naturally occurring DNA molecules are always double-stranded while the RNA molecules are single-stranded and this shows the physical difference between a DNA molecule and that of RNA. However, there are several disparities and numerous exceptions which shows that some viruses have genomes made which are made of double-stranded RNA while other viruses have single-stranded DNA genomes a phenomenon which has been seen to contradict the scientific facts known
The Nucleic acids are seen to be linear polymers which make chains of nucleotides. In such chains, each nucleotide is made up of three components which are discussed above. These structures are further subdivided into the nucleobases that is found in the two nucleic acids. These subdivisions include: adenine, cytosine, and guanine which are all found in both RNA and DNA molecules. In contrast,
Understanding DNA can take a lot of studying and confusion to even get the general idea of the concept. The structure of DNA is very complicated and complex to understand, but researchers James Watson, Francis Crick, Maurice Wilkins, and Rosalind Franklin all developed the idea of the DNA structure in 1953. Deoxyribonucleic Acid is found in the nucleus of the cell. It is a double stranded molecule that contains the genetic code and is the main component of chromosomes. DNA is the blueprint of organisms. Nucleotides are the basic unit of DNA and they are made up of sugar, phosphate, and one of the four basis including adenine,
• *Compare and contrast the structure and function of DNA and of RNA molecules. Reference Table 4.1.
Ribonucleic acid (RNA): It is a single nucleic acid supported by adenine, guanine, cytosine and uracil supported by ribose sugars. mRNA, rRNA and tRNA.
A Matching—Nucleotides: DNA and RNA 1. A 2. F 3. D 4. C 5.
D)Nucleic Acids monomer(s) are called nucleotide. The functional group is dna(Deoxyribonucleic acid) and rna(Ribonucleic acid). The linkage type is covalent bonds and hydrogen bonds. The primary function of nucleic acid is to store and transfer genetic material.
When analyzing DNA it is important to understand it and all the chemicals that it is made of. The first thing that’s important to know is simply what DNA stands for, which is deoxyribonucleic acid. The chemical units are called nucleotides, and each nucleotide has a compound of phosphate sugar which is the backbone, and a sugar deoxyribose. The Phosphates and sugars are the same in all nucleotides but the one thing that is different would be the bases. DNA bases are cytosine, thymine, adenine, and guanine. Each base has specific partner, for example Cytosine will always pair with guanine. And Thymine will always pair with adenine.
Besides, nucleic acids convey information that is utilized as a part of the development of particular proteins by living cells. This is because DNA arrangement doesn 't consider the most comparative structures of some amino acids to others and the comparable practical part they have in the protein. For instance, valine and isoleucine
DNA structure is composed of a double helix, constituting two strands twisted around one another. Each strand have a linear arrangement of building blocks called nucleotides or bases (adenine, thymine, cytosine and guanine). These strands
The large number of molecular groups made available for binding by each nucleotide component meant that there were numerous alternate ways that the components could combine. Several scientists put forth suggestions for how this might occur, but it was Levene's "polynucleotide" model that proved to be the correct one. Based upon years of work using hydrolysis to break down and analyze yeast nucleic acids, Levene proposed that nucleic acids were composed of a series of nucleotides, and that each nucleotide was in turn composed of just one of four nitrogen-containing bases, a sugar molecule, and a phosphate group. Levene made his initial proposal in 1919, discrediting other suggestions that had been put forth about the structure of nucleic acids. In Levene's own words, "New facts and new evidence may cause its alteration, but there is no doubt as to the polynucleotide structure of the yeast nucleic acid"
The nucleic acid is needed in the body to keep our dna. Nucleic acid is a macromolecule that stores and communicate genetic energy. There are six major nucleotides and it is made of carbon nitrate, oxygen, phosphorus, and hydrogen. In living organisms there are two types of nucleic acids called deoxyribonucleic acid and ribonucleic acid. DNA and RNA in the nucleic acids bonds into the phosphate of another nucleotide. ATP stores energy in a storehouse and it could only be used by cells in a variety of reactions. ATP releases energy when the second and the third phosphate group is broken. Triphosphate is a nucleotide with three phosphate group. Nucleotides are smaller repeating subunits made of nucleic acids.
The genetic material is carried by the DNA and is present in the nucleus of every eukaryotic cell and in the mitochondria and chloroplasts. Deoxyribonucleic acid (DNA) is a large macromolecule composed of nucleotides as monomers. Each nucleotide consists of a ribose sugar (pentose 5-carbon sugar), a negatively charged phosphate group that gives the DNA its polarity and acidity, and one of four nitrogenous bases (Adenine, Thymine, Guanine, and Cytosine). Every two nucleotides are linked together by a 3’-5’ phosphodiester bond, and thereby a series of these bonds forms one of the two strands of the double helix. Moreover, the two strands are connected together in an anti-parallel manner by hydrogen bonds, forming the DNA double helix. Whereby Adenine and Thymine are complementary and linked together by two hydrogen bonds, while Guanine and Cytosine are linked by three hydrogen bonds. This DNA molecule is then coiled and accompanied with histone protein to form the chromosomes.
Nucleic acid molecules which are to be analyzed are set upon a viscous medium, thegel, where an electric field induces the nucleic acids to migrate toward the anode, due to the net negative charge of the sugar-phosphate backbone of the nucleic acid chain. The separation of these fragments is accomplished by exploiting the mobilities with which different sized molecules are able to pass through the gel. Longer molecules migrate more slowly because they experience more resistance within the gel. The DNA fragments of different lengths are visualized using a fluorescent dye specific for DNA, such asethidium bromide. The gel shows bands corresponding to different nucleic acid molecules populations with different molecular weight. Fragment size
Deoxyribonucleic (DNA) is the molecule that hold the genetic information of living things. In our body every cell contains about 2 meters of DNA. DNA is copied every time a cell divides. Deoxyribonucleic (DNA) is made up of two polynucleotide strands. Polynucleotide strands twist around each other, forming a shape that looks like a ladder called a double helix. The two polynucleotide strands run antiaparallel to each other with nitrogenous bases this means that the stands run in opposite directions, parallel to one another. The DNA molecule consists of two backbones chains of sugars and phosphate groups. The organic bases held together by hydrogen bonds. Although bases bonded together are termed paired
Due to the DNA’s specificity, samples can be utilised for identification. DNA is a nucleic acid composed of deoxyribose sugar bound to a phosphate group and one of four nitrogenous bases (adenine, guanine, cytosine and thymine). Each section of these three components are referred to as nucleotides, which are joined to the phosphate or sugar of another nucleotide by strong covalent bonds to form a backbone. The nitrogenous bases are joined to complimentary bases of another nucleotide (adenine with thymine, guanine with cytosine) to create a double stranded molecule (Figure 2). To complete the double helical structure, the molecule coils to compact it’s contents. DNA molecules can contain up to two million base pairs, with a human genome containing approximately 3 million base pairs. The random assortment of nitrogenous bases as well as the numerous mutations within certain DNA sequences, results in genetically diverese DNA molecules and genomes between individials.