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Ble Constructive Stricture: A Case Study

Decent Essays

INTRODUCTION

Bile duct stricture is a rare but challenging clinical condition. There is often delay in diagnosis of biliary stricture because of its slow progression. Benign strictures develop due to injury of the bile ducts during surgery or trauma to the abdomen; a recurring condition like pancreatitis or bile duct stones or a chronic disease like primary sclerosing cholangitis (PSC). Inflammation occurs soon after injury, which is followed by fibrosis and narrowing of the bile duct lumen. Degeneration of the hepatic segment or lobe void by the involved bile ducts, associated with hypertrophy of the natural segments, can occur, especially with chronic strictures. These changes eventually develop to portal hypertension and secondary biliary …show more content…

Several studies have been done for detecting malignant biliary strictures .For example, osteopontin was the most consistently overexpressed gene in intrahepatic cholangiocarcinoma (Hass et al. ,2008). In this work, we have ana¬lyzed microarray data to identify differential expressed genes between malignant and benign biliary stricture and association of these genes with liver cancer using a computational bioinformatics analysis. These genes may be possible targets for future drug design or identification of cholangiocarcinoma …show more content…

Raw data were processed and normalized by the Robust Multichip Averaging (RMA) method (Irizarry et al., 2003) using affy packages of R(v. 3.1.3) (Team, 2004) .The linear regression model package limma (Smyth, 2004) was used to classify chips into each group. The Bayes method (Benjamini and Hochberg, 1995) was used to correct for multiple testing. |logFC| > 2 and P-value < 0.05 were used as cutoff to identify genes which are differentially expressed in

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