Blood Brain Barrier Research Paper

There are many expecting mothers who suffer from serious mental illnesses like schizophrenia, bipolar disorder, or borderline personality disorder that requires they must take antipsychotic drugs to remain stable. There are different types of antipsychotics like typical and atypical. Typical antipsychotics are classified as the first generation of antipyschotics. The atypical antipsychotics, the second generation, are reported to be safer than the typical antipsychotics because they are the newer form of antipsychotic medication. Even though they are reported to be safer, they still have severe side effects on the individual consuming it, like tardive dyskinesia, which are uncontrollable movements of the mouth (McCauley et al., 2009). Some drugs can affect the fetus by transferring to the blood-brain barrier. The blood-brain barrier is a permeable barrier that allows some chemicals to pass through. It separates the circulating blood from the brain extracellular fluid in the central nervous system. The blood-brain barrier also transports molecules to the brain that are essential to function properly, like glucose and amino acids. Since capillary endothelial cells, which line the whole circulatory system, form the blood-brain barrier the medication could be transported to the fetus. From

In the article “Head Rush,” Laura Sanders explains the role blood has upon our brain. As blood travels our body, it takes in our information, thoroughly giving us details on our health ,genetics and many more. Our blood actually has a bigger job that many of us didn’t know about. Past experiments are suggesting that blood has the power to control nerve cell, instead of just taking commands from them. Science textbooks point out that astrocytes connect neurons and blood vessels, but it is still uncertain as to how neurons receives its signal to carry blood to the brain. Sanders talks about two neuroscientists Robert Hill and Jaime Grutzendler of Yale University published work. Hill claims that, “endothelial cells are perfectly poised to detect

amount of the fluid that protects the brain and spinal cord. The fluid is tested to

Correspondingly, there are two pathways that transports blood to the brain called internal carotid artery and vertebral artery. The internal carotid artery has three layers call the tunica adventitia, tunica media, and tunica intima. Tunica intima is made up of smooth muscle cells and elastin. The basilar artery forms and it branches out to the posterior cerebral arteries. The posterior cerebral arteries form the internal carotid arteries and when they connect they make cerebral arterial circle ( circle of willis). The middle cerebral arteries branch out two separate arteries called the anterior cerebral arteries. Each of these arteries are the force that direct the blood flow to the brain. There are three tiny vascular systems that work together to profuse the deep brain. Which are the pial, subependymal, and lenticulostriate arteries. The small area of white matter that depends on blood flow is called the subcortical “shed water” area. The subcortical is more prone than other areas of the brain to have ischemia. The leading cause of ischemia is the fibrin builds up and this cause a narrowing of the lumen. Which does not allow the flow of red blood cells and deprives the white matter of tissue of oxygen. The tissue then losses density and produces white matter lesions. The neurons become demyelinated which leads to loss of cognitive ability.

It is speculated to be the source of 10-20% of dementia cases, which is not unexpected due to the fact that in America alone, “Every year, more than 795,000 people in the United States have a stroke…” (https://www.cdc.gov/stroke/facts.htm) . “In this condition, changes in the brain’s blood vessels restrict the amount of blood and oxygen reaching particular areas of the brain – resulting in the death of brain cells...” (https://qbi.uq.edu.au/brain/dementia/types-dementia) .

The brain is supplied with blood by two internal carotid arteries and two vertebral arteries. These arteries form the anastomosis known as the Circle of Willis. In 1951, two researchers, McDonald and Potter demonstrated that, "the blood supply to half of the

Vascular dementia is a decline in thinking skills caused by conditions that block or reduce blood flow to the brain, depriving brain cells of vital oxygen and nutrients. Conditions that can block blood flow to the brain are generally transient ischemic attacks (TIA’s) or stokes. When these occur, often major brain blood vessels are damaged and blocked causing effects on personality, ways of thinking and problem solving, and generally can coexist with

The topic assigned to me for the health paper is cerebrovascular disease, which is a stroke. Cerebrovascular is really two words combined. Cerebro is the largest part in the brain and vascular is termed as veins and arteries. From those two terms, one can interpret that this disease has to deal with the blood flow that goes on in the brain. According to the Association of Neurological surgeons, cerebrovascular disease is defined as the any disorder that is in the brain is either permanently or temporarily affected by bleeding and even by ischemia (AANS, 2005). It states, “ Cerebrovascular disease includes stroke, carotid stenosis, vertebral stenosis and intracranial stenosis, aneurysms, and vascular malformations” (AANS, 2005). When this

oxygen. The brain can be deprived oxygen either by a blockage such as a blood clot, or the

The nervous system and the endocrine system regulate all body functions (class notes). But, certain diseases and disorders can affect any of these organ systems. One disorder that can affect the brain is a cerebrovascular accident (CVA), also referred to as a stroke. CVA usually results from either a blood vessel in the brain that has burst and decreased the flow of blood to a specific area of the brain or a blood clot that blocks the flow of blood to specific areas of the brain. Either of these causes can result in the brain tissue being deprived of nutrients and oxygen, which will make the brain tissue die (class notes). The following features a study on the association between Chlamydia pneumoniae (C. pnuemoniae) and cerebrovascular accidents.

1. Resveratrol plays a vital role in preserving the blood–brain barrier (BBB) integrity, reducing brain water content and improving neurological outcomes after subarachnoid hemorrhage (SAH).

The over the counter medication once known only for its ability of easing aches and pains or fighting off fever and inflammation is proving itself to be quite the miracle drug. Aspirin has become part of the protocol for stroke victims as a preventative measure due to its neuro-protective benefits. Stroke can cause lesions in cerebral white matter, which may result in cognitive impairments such as deficits in learning and memory. White matter lesions (WML) have also been linked to increasing the risk of post-stroke dementia. Cerebral white matter damage has been widely overlooked. Comprised of oligodendrocytes that form the insulating myelin in the CNS, white matter is evidentially just as vulnerable to ischemia as gray matter.

     The blood brain barrier protects brain cells from harmful substances, as well as, pathogens, by preventing passage of many substances from blood into brain tissue.

Our brain is most complex organ system in our body. This three pound of tissue creates the main nerve center of the body. It controls our all body function, body movement, thought, and our behavior. Many of people do not know about the how a brain works? The left part of the brain controls our right side of the body and right side of brain part controls our left side of the body part. Our brain uses 20% of the total oxygen and blood in the body so it is required oxygen and nutrition from the blood for work properly. The lake of oxygen in the brain for 5 to 10-minute results in permanent brain damage or occurs a stroke. A stroke occurs when the blood supply to part of our brain is interrupted or severely reduced. A stroke is one of the diseases

That layer of cells forms a barrier between the capillaries and the cells and fluid of the brain.