Blood Glucose Regulation And Negative Feedback

The blood glucose level has very limited range for humans to survive and stay healthy. Generally, people are able to remove excess glucose rapidly from the body but this is not the case when they are diagnosed with diabetes and insulin resistant situations. The lack of insulin resistance can also lead to a decrease in glycogen synthesis and storage as it usually converts glucose to energy for cell’s use (Jensen & et al. 2011). When insulin is produced under insulin resistance, the cells are incapable of using them effectively which then leads to high blood sugar level as ketones and ketoacids are produced as an alternative energy source for the body. The rise of ketoacid causes the blood pH acidic and the patient may also be diagnosed with ketoacidosis (Newton & Raskin 2004). There would also be less intake of lipid and more of stored triglycerides as the lipids are effected by the insulin. As the glucose levels increase, the muscle glucose uptake will decrease while the liver glucose production and blood fatty acid concentration will also increase within the body (Lichtenstein & Schwab 2000). Excess glucose within the blood are converted to fat which can lead to Diabetic Dyslipidaemia and furthermore to obesity, hypertension and

Homeostasis is a biological process that maintains a constant internal environment, regardless of what is going on in the external environment. This process ensures the bodily functions and chemicals are kept in a state of balance which in return allows the body to function optimally. Homeostasis requires coordination of the hormonal (endocrine system) and nervous systems, which together regulate the activity of the body’s organ systems. The regulatory activities are constantly adjusted in response to stimuli (change) from both the internal and external environment. A change influenced by the external environment can cause a state in the body that will take it away from the normal, the body will act to counteract this change and return the internal environment back to a steady state. This is negative feedback. Negative feedback has a stabilising effect reducing changes from a set point and returning internal conditions to a steady state. Most body systems e.g. controlling blood glucose levels, obtains homeostasis through negative feedback which makes the negative feedback system critically important in obtaining homeostasis. However there is also positive feedback which is a system that results in the escalation of a response to a stimulus. It causes instability in the system and is used when there is a specific outcome required. Positive feedback ceases once the natural resolution is reached e.g. baby is born, pathogen is destroyed, blood clot forms. This system is not used

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Results: According to Table 7.1 for the non-diabetic blood glucose sample measured in tube one .012, tube two .138, tube three 38, tube four .15 and tube five .06. For the diabetic blood glucose sample measured in tube one .16, tube two .71, tube three 1.5, tube four 1.05 and tube five .69.

Diabetes is one of the most prevalent diseases to this day. With over 171 million cases of diabetes all over the world, this disease is spreading exponentially fast. Lesser known as Diabetes Mellitus, this disease is all about the amounts of sugar in one's body. Glucose, in particular. Glucose is the powerhouse of the body. It helps run your body by transforming into the energy that we use to function on a daily basis. Whether or not one's diabetes is minor or even off the charts it can lead to terrible outcomes. These include stroke, blindness, vascular disease and heart disease. As mentioned before, the major symptom of diabetes is that too much sugar is in one's body. This is similar to a disease previously mentioned, hemochromatosis. However,

Diabetes one, and two revolve around the hormone insulin. Insulin is produced by the pancreas and its job is to help the cells in the body absorb glucose from the blood. Once the glucose is absorbed it signals beta cells from the pancreas to secrete insulin. Insulin enables glucose to enter cells of the liver and muscle. After the glucose has entered the cells, hormones that include insulin, decided if the glucose will be used as energy, or stored as glycogen for the future. The stored glycogen is important because if you haven’t eaten and your blood sugar is low, the body can take from the stored glycogen and use it as a source of energy.

Diabetes is a chronic disease in which a person’s glucose (blood sugar) is higher than normal. After our bodies have digested foods and turned them into sugar, the pancreas produces insulin. Insulin helps the body take sugar (blood sugar) out of the bloodstream and helps to shuttle it into our cells to be used for energy. If a person has diabetes, their bodies either doesn’t make enough insulin (Type II) or the body doesn’t use the insulin as it should (Type I). Either of these conditions can result in high sugar (glucose) levels (CDC, 2013).

Common ways used to asses’ diabetes is through blood glucose meters. The blood glucose meter is a small device that pricks your finger in order to draw your blood and analyzes the glucose present in the blood (Guell 2012). This will allow individuals to asses whether they are diabetic or not. Furthermore, doctors recommend people regulate their diets and weight and engage in physical activity in order to prevent diabetes from

The body must keep a healthy blood glucose level so that there is a continuous supply of energy to the cells. If the blood sugar levels fall too low (hypoglycaemia) it can cause harmful complications such as fatigue and even loss of consciousness. If blood sugar levels raise too high (hyperglycaemia) it can lead to many difficulties such as cardiovascular disease, nerve damage and kidney damage (S Preet, 2013). This is why is important for the body to regulate its glucose levels. It does this by the pancreatic islets detecting a change in blood glucose levels, they then release the hormone insulin into the blood stream. Muscle cells are prompted by the insulin, to absorb glucose. The way insulin does this is by binding itself to receptors on the cell membrane, thuds increasing the amount of transporters and allowing more glucose to be transported into the cells. If glucose levels fall then another hormone is released by the pancreas called glucagon. Glucagon allows stored glucose (glycogen) to be released from the liver into the blood stream and raises blood glucose levels (Amis, 2011). This process of keeping blood glucose levels constant is an example of ‘homoeostatic control’ where the rise and fall of glucose levels allows each different hormone to be used in a constant

While typical healthy individuals use insulin to draw sugar into their cells for energy usage,

Well this all starts with knowing what glucose is. Most of the sugar in your body is called glucose. Glucose’s main job is to supply the body with energy. The body breaks down glucose. Releasing energy, water and carbon dioxide. It used by almost all tissues in the body, and is the only fuel the brain can use. If your glucose is too high or low this is caused by diabetes.

Homeostasis is the maintenance of near constant conditions/ state of the internal environment of an organism, this is important for the organism as it needs to maintain a near constant internal environment, it does this by allowing the body cells to function at optimal levels so internal and external influences don’t affect the state and conditions of the organism. An example of a homeostatic system is blood glucose regulation. It is the process that is maintained by the body for the levels of blood sugar; glucose, Glucose regulation is a process in the body that keeps it in homeostasis; insulin and glucagon are the main hormones involved in the process. Blood glucose is produced from food we eat, especially carbohydrates, fats and proteins, this is the main source of energy for the human body. Blood glucose is transported to the cells by the circulation and into cells by glucose transporters; some are regulated by insulin. Insulin is one of the hormones produced by the pancreas in which regulates the glucose levels in the blood around the body. Glucose is needed for respiration and the concentration levels of glucose in the blood is important to be kept and maintained at a near constant level (70 to 115mg, in a normal adult). Hyperglycemia means high blood glucose levels, this can caused by several factors such as poor food/ diet and physical activity choices and even illness. The body needs glucose to properly function due to being

energy. When a person consumes food with sugar, the sugar is broken down into glucose. Glucose is used as an energy source for the body and is transported throughout your blood into the cells by insulin. Without proper amounts of insulin, your body is unable to use the glucose as

Glucose is the primary energy source for the brain and it also serves as a source of energy for cells throughout the body. The energy provided by glucose helps the cells to carry out nerve cell conduction, muscle cell contraction, active transport and the production of chemical and metabolic reactions. These processes are all essential for the bodies survival and all require glucose to carry out their actions. Blood glucose regulation is the process by which the levels of blood glucose, are maintained by the body. The regulation of blood glucose in the body is a process of maintaining homeostasis. The purpose of homeostasis is the maintaining of the body’s internal environment in a steady state despite fluctuations from the external and internal environments. The homeostatic systems require the hormonal system to regulate the activity of the body’s internal organ’s systems. Homeostasis in the regulation of blood glucose is maintained at the level of 3.9-5.6molL-1. It is important for to keep the blood glucose level around the set point as many cells in the body require glucose as an energy source to carry out respiration and other cellular and metabolic processes. The blood glucose mechanism uses negative feedback to maintain the set point of glucose at 3.9-5.6molL-1. Negative feedback is the “corrective” mechanism which automatically reverses the change in the system whenever a change occurs- it brings the blood glucose level back to the set point of 3.9-5.6molL-1. The

The purpose of blood glucose regulation is to maintain the levels of blood sugar in the body at homeostasis. As humans, our bodies rely on our blood glucose levels to be maintained within a very small range (approximately between 5mM and 10mM). It is important for blood glucose levels to remain stable and within these approximate boundaries because the brain and body struggle to function properly outside of this range. Insulin and Glucagon are both pancreatic endocrine hormones secreted from the pancreas in order to maintain homeostasis in blood glucose regulation. It is the production of these hormones that is necessary in humans in order to prevent diseases such as diabetes or hypoglycemia from developing.