Précis
Brain and Central Nervous System Cancers
By Elissah Granger
In healthy individuals, cells grow, divide and die in a highly regulated fashion. When irreparable damage occurs to DNA this cycle is interrupted; resulting in apoptosis, programmed cell death, or uncontrolled cell growth, known as cancer. Cancer is the leading cause of death in Australia, accounting for about 3 in 10 deaths (Cancer Council, 2014). In 2010; 116, 580 new cases of cancer were diagnosed and there was a 1 in 3 risk of developing cancer in individuals below the age of 75 (AIHW, 2014). Since 2000, over $1.5 billion in research grants, from the National Health and Medical Research Council (NHMRC) has gone into cancer and cancer control issues. In 2013, there were 921 active research grants with $186 million dollars in funding in total (NHMRC, 2013). Of this funding, only 3% has gone towards brain and central nervous system (CNS) cancers, totalling just under $48 million.
Figure 1: Graphical summary NHMRC research funding from 2000-2013 of Cancer and Related Malignant Neoplasms.
In 2010, 1680 brain and CNS cancers were diagnosed in Australia and 1250 deaths occurred as result of brain and CNS cancers. The risk of being diagnosed with brain and CNS cancer by age 85 is 1 in 95 for men and 1 in 152 for women, the risk of death from brain and CNS cancer by age 85 is 1 in 124 for men and 1 in 193 for women (AIHW, 2014). Brain and CNS cancers include primary tumours, which start in the brain or the
Glioblastoma (pronounced like gleO blastoma) is an incurable brain cancer,Survival rate is usually measured in months.This became a word that was instantly defined, researched, dissected, feared, and tried to comprehend and understand by family,friends and acquaintances of Larry McKee (McKee)who was personally affected from this single word, it was quickly added to their vocabulary, because of the of the events that transpired on October 22, 2011 that forever changed lives “Glioblastomas are tumors that arise from the astrocytes- the star-shaped cells that make up the “glue-like,” or supportive tissue of the brain. These tumors are usually highly malignant (cancerous) because the cells reproduce quickly and they are supported by a large network of blood vessels.”(A.B.T A..) He was diagnosed with stage four.
The primary ones include these types. Gliomas, the most common brain tumor involving the brain tissue. There are different grades and even types of gliomas. But if the tumor grade is higher, it will probably grow faster. Medullblastomas are brain tumors that in young children. Without treatment it will spread rapidly into the spinal fluid and other parts of the brain. But almost or half of the brain tumors found are benign. These types of brain tumors are usually Meningiomas and Neuromas. Meningiomas begin in the tissue membranes. Neuromas are in the nerves mostly in people over
The CDC estimates that each year, more than eight million people are diagnosed, and consequently died from cancer, and this statistic was even higher in the 1950s. During this period, little was known of cancer’s effects on the
Dr Jennifer Chan, the head of this tumor research, is an Associate Professor & Neuropathologist in the Department of Pathology & Laboratory Medicine, Oncology, and Clinical Neuroscience in the University of Calgary. Besides her work on education, she is also directing a tumorigenesis research team at the University of Calgary, and a tumor banking program which supports pediatric cancer research. Nonetheless, she is also a member of both the Southern Alberta Cancer Research Institute and the Experimental and Applied Therapeutics Program (ExpAT).
The American cancer society estimated that 18,500 people would be diagnosed with brain tumor and those 12,760 men and women would die of brain cancer in 2005.The National Cancer Institute (NCI) estimated that 22,070 new cases of brain and other central nervous system (CNS) cancers would be diagnosed in the United States in 2009. The American Brain Tumor Association (ABTA) clarifies this statistic further by estimating that 62,930 new cases of primary brain tumors would be diagnosed in 2010. By the year 2030, there will be 26 million new cases, and the death toll will reach to around 1.7 million people. According to World Health Organization (WHO), there are more than 120 types of brain tumors.
Cancer is one of the leading cause of death in Australia and has a considerable social and economic influence on individuals, families and the community. Statistics shows that Australia has third highest cancer rate approximately 323 people being diagnosed per 100,000 in the world. (Begg & etal, 2007, pg.116). According to the recent disease study in burden of disease by WHO and Global Burden of disease study 2012, the findings of study showed 16% and 19% of the total disease burden in Australia (Moore & et al, 2007 pg.88)). Cancer is the sixth most expensive chronic disease due to the high expenditure of treatment and management compared to other chronic disease. It has been further described that approximately $4.5 billion were spent on cancer in 2008-09, accounting for 7% of total healthcare expenditure on chronic disease (Australian Institute of Health and Welfare, 2013b, p.7) and 79% of total expenditure that spent on cancer patients who were admitted in hospital which is 20% more than the same expenditure that was spent on all
CNS tumors represent the second most frequent tumor of childhood and the most common pediatric solid tumor; approximately 2,200 patients under the age of 20 are diagnosed each year with invasive CNS tumors, and CNS tumors are the number one cause of death from childhood cancer. [1] Therapeutic strategies generally involve surgery as a primary intervention, but complete resection is often not possible due to tumor location. In such cases, adjunct therapies, including chemotherapy and radiation therapy, may be required based on the tumor histology and presence of residual tumor. [2]
The most common cancers that have ended in death are, lung, bowel, prostate (males), breast (females) and pancreatic cancers. These cancers are the most common within the older population due to the time when they were young, their wasn’t any or many knowledge about cancer and how to prevent cancers. For example, 50% of lifetime exposure happens in early life and the skin cancer
Cancer is the main cause of death in the world, estimating 8.2 million fatalities in 2012 alone
Primary brain cancer develops from cells within the brain. Part of the central nervous system (CNS), the brain is the control center for vital functions of the body, including speech, movement, thoughts, feelings, memory, vision, hearing and more.
Common malignant brain cancers increase significantly according to statistical data collected by the National Cancer Institute. In 1984, the annual incidence rates of primary brain tumor and primary brain lymphoma also increased notably, the rate of lymphoma almost tripling,
Although research and treatment of common cancers such as breast cancer have been efficiently funded by the government, RLC cancers are lacking substantially in all aspects. This issue needs to be addressed as it has led to critical deficiencies in the scientific establishment of rare cancers, significantly lower survival rates and difficulties in treatmentment access. In order to prevent the existence of such inequalities, it is vital that the government must provide supplementary
Cancer, one of the most feared words in our vocabulary of this time, especially in childhood (Druker 1). Most people when thinking of “childhood cancer” envision very young children, although a “Nation Institute of Health Policy concerning inclusion of children in clinical research defines children as being younger than twenty-one years of age while the Food and Drug Administration considers children to be fifteen years and younger” (Ries 158). That being said, most cancers incidence peak among children occurs during the first year of life (Gurney 149). Some of the most well-known nationwide childhood cancers are leukemia, brain cancer, and other central nervous system cancers (oeconline 1). In conjunction, “the side effects of treatment,
The CM data (code C43, the International Classification of Diseases10th revision) registered from 1983 to 2013 were derived from Hong Kong Cancer Registry, Hospital Authority (http://www3.ha.org.hk/cancereg/c_a1b.asp, accessed 18th, June, 2016). Briefly, the Hospital Authority manages the Hong Kong’s public hospital services, and the Hong Kong Cancer Registry is a population-based cancer registry and a member of the International Association of Cancer Registries. The full dataset used in this study was attached as the Supplemental Table S1 and Supplemental Table S2. It contains the following categories: sex, five-year age groups, diagnosed cases, deaths, and age standardized rates (ASRs, per 100,000 person-years) of incidence and