Brain Derived Neurotrophic Factor ( Bdnf )

1720 Words Apr 7th, 2015 7 Pages
I. Abstract Brain-derived neurotrophic factor (BDNF) is known to increase synaptic efficacy and promote neuronal survival. This protein is also a biomarker for impaired general cognitive function and memory. Studies have bee conducted on mice measuring the concentration of circulating, also called plasma or serum, BDNF in the blood of these animals when they exercise. Exercise has been proven to increase cognitive function and links between a large level of BDNF in the bloodstream and improved results on spatial/ cognitive testing of these rats shows that BDNF correlates to an increase in memory and cognitive abilities. In this research, studies with varying results on BDNF and exercise were taken and summarized in hopes of finding a link between this protein and exercise as well as the combined effects of these two on the cognition and memory of human subjects. A definite link was found between BDNF, exercise, and cognition, but results were too spread out to conclusively assert that increased BDNF is what causes increased cognitive abilities and memory post-exercise.

II. Introduction Brain-derived neurotropic factor (BDNF) is a neurotropic factor. A neurotropin is a protein that helps neurons survive. A growth factor is a protein that signals certain cells to survive, grow, and differentiate based on a number of different influences. The receptor for BDNF, TrkB, and BDNF itself are expressed in the smooth and skeletal muscle, pancreas, endothelial cells, and…
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