Brain Injury Enhances Fear Learning And Excitatory Processes

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The article, Concussive brain injury enhances fear learning and excitatory processes in the amygdala by Maxine L. Reger, Andrew M. Poulos, Floyd Buen, Christopher C. Giza, David A. Hovda, and Michael S Fanselow took a close look into the fears and behaviors generated in rats two days after suffering trauma to the brain. This particular article was discovered by searching the keywords: brain injury and amygdala, in the PubMed database. By searching those keywords, the database was able to pull up numerous articles discussing the two topics, but I felt that Reger et al (2012) demonstrated a clear association between the topics. The article brings about a question of whether or not there is a link between brain injuries, posttraumatic stress disorder, commonly referred to as PTSD, and the changes involved in the excitatory and inhibitory processes involved in the amygdala. In order to examine such a link, the authors performed a number of tests on adult Sprague-Dawley rats to test their hypothesis as well as to investigate the neurobiological correlation between concussion and PTSD. To further assess these correlations, it is imperative to explore the methods used to conduct this study. The experiment was conducted using adult male Sprague-Dawley rats from the Charles River Laboratories in Hollister, California. The rats were housed in cages, two rats per cage, for a 12 hour light/dark cycle. The investigation began by combining the use of lateral

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