Siv Research Paper

“some way must be found to permit the SIV to remain at high levels in people for long enough that such spontaneous mutations might take place. He suggests that the required mechanism is "serial passaging" of virus through unsterile needles. That is, a cut hunter might get an injection while he is still harboring large numbers of viral particles in his bloodstream; that same needle would then be used to infect another person, who might soon receive a second injection, and so forth. High viral population levels can thus be maintained in a series of different people getting shots. With each transfer via contaminated needle, the virus finds itself in a fresh host, with an opportunity to proliferate before the infected person can mount an immune response. Chance mutations can thus accumulate, and eventually the SIV adapts, becoming HIV.”

Numerous species of monkey were infected with the Simian Immunodeficiency Virus (SIV) or Simian-Human Immunodeficiency Virus (SHIV). The macaques were the primary group of monkeys infected. “Macaques are physiologically and immunologically similar to humans so there is a significant advantage over rodents and other species. The pathogenic SIV infection of macaques can lead to a disease that is called “simian AIDS;” it is similar in many respects to the disease caused by HIV-1 in humans” (Evans and Silvestri). Using the macaques allows different treatments to occur on the experimental level that cannot be conducted in humans. The treatments have provided and continue to provide “essential information to reach a deeper understanding of the biology of HIV infection and AIDS” (Evans and Silvestri). Non-human primates are easier to use than humans do to the ability to control the timing, dose and route of the virus as well as collecting the samples from tissues that are difficult to collect from humans. Macaques can be infected by vaginal or rectal routes or by oral routes. Macaques have been used to test various “microbicides and vaccines for mucosal protection against HIV acquisition” (Evans and Silvestri). By using non-human primate models for studies of AIDS, many results have been

It is believed that the first case of HIV/AIDs was first recorded somewhere in West Africa somewhere in the beginning of the twentieth century. Since then, it has spread across central Africa, undetected for a long time. But the question that has bewildered many, is how HIV spread in the first place. According to “Natural Transfer Theory”, HIV was spread to humans through chimpanzees. “Africans have been killing and eating monkey for at least fifty thousand years” (43). It was common for small African communities to hunt and eat chimpanzees. Chimpanzees were said to have “SIVs, simian immunodeficiency viruses that closely resembles HIV” (41). The virus is said to have spread to humans through these infected chimpanzees. The blood of these chimpanzees could have

During the initial infection, the infected are reported to experience a period of influenza-like symptoms, which are soon followed by an extended period of time without any visible anomalies. As the conditions of the infected person worsen, it causes more and more problems with the immune system. The complications plaguing the immune system makes it difficult for the immune system to effectively combat disease. This results in the infected person becoming more likely to get infections. HIV spreads primarily via sexual intercourse conducted without adequate protection. Other ways to contract the disease are: contaminated blood transfusions, hypodermic needles, and passing from mother to child during pregnancy, delivery, or breastfeeding.

Pathogens are a type of microorganism that spreads viral and bacterial diseases. These diseases when present in human blood and body fluids are known as blood borne pathogens, and can spread from one person to another. (Worcester polytechnic institute) The most serious types of blood borne diseases are the hepatitis B virus (HBV) and hepatitis C virus (HCV), which can cause liver damage; and HIV (human immunodeficiency virus), which is responsible for causing AIDS (acquired immune deficiency syndrome). The blood borne pathogens can be spread when the blood or body fluids (semen, vaginal fluid, breast milk, and amniotic fluid) of an infected individual comes into contact with mucous membranes or an open sore or cut on the skin of another

This “simian” or monkey pathogen then developed and evolved into the present day contagion called aids. Transfers of human bodily fluids, sex, and the reusing of infected needles spread aids. This Disease weakens the immune system, with the possibility of death. It affects people by them having intercourse with infected people, and by the sharing of needles. It is not contagious like the Black Death but is still deadly. 3 million people died last year by aids. Aids are a serious thing, as minor ailments can kill you. In the year of twenty fourteen, there was a study that showed that 36.9 million people had aids, and one and a half million died of it.

James is continuous maintaining all of his responsibilities in SIV (Scanning, Indexing and Verification) Section and assisting mailroom when needed. His work is conscientious and accurate.

HIV stands for human immunodeficiency virus and can lead to acquired immunodeficiency syndrome (AIDS) if not treated (About HIV/AIDS, n.d). Unlike some other viruses, the human body cannot fully rid itself of HIV completely, even with treatment. Simply put, once you contract HIV, you have it for life. This disease attacks the body’s immune system, specifically the CD4 cells (T cells), which help the immune system stave off infections. When left to its own devices, HIV reduces the number of CD4 cells (T cells) in the body, making the person more likely to

HIV which stands for human immunodeficiency virus is a virus that attacks the human infection fighting CD4 cells of the immune system. AIDS which stands for acquired immunodeficiency syndrome, is the most advanced stage of the HIV infection. If HIV is left untreated it leads up to AIDS, and that is when the immune system is too weak to fight off infections or even certain cancers. HIV is spread through certain body fluids such as blood, semen, pre-seminal fluid, vaginal fluids, rectal fluids, and breast milk. In the United States HIV is commonly spread by having sex with someone who is infected or by sharing drug injection needles. HIV is not airborne so you cannot get infected by a simple

The evolution of Human Immunodeficiency Virus (HIV) was originated from acquired immune deficiency syndrome (AIDS) is a pandemic disease in which creates unembellished harm of body cellular immunity and promotes decrease resistance to infection. This disease was formally predictable in patients of the United States in 1981 and the World Health Organization (WHO) estimated in 1988 that “five to ten million people worldwide are infected with AIDS” (Hunt 1989 p. 353-373). However the main catalyst of HIV was derived from the original host of an infectious chimpanzee in West Africa referred to as simian immunodeficiency viruses (SIVs) (Sharp & Hahn 2010). The recent article ‘The Evolution of HIV-1 and the Origin of AIDS’ illustrated by Sharp and Hahn (2010) proposes that there is a likelihood of transportation of the disease between chimpanzee to human beings through “exposure to infected blood and body fluids during the butchery of bush meat”. It was put forward, that after years of observation, it was established that women who were diagnosed SIV-positive had a fertility reduction in regards to the

Both diseases have mainly been affecting human beings since its discovery in 1981. They cause the immune systems to deteriorate by destroying white blood cells and hindering their ability to fight against illnesses ("What Is", 2014). When one participates in high risk events such as having unprotected sex, sharing contaminated syringes, blood transfusions or organ donations, tainted fluids may enter the body through the mucous membrane, damaged tissue or by direct injection into the bloodstream when one is not cautious (“How Do”, 2014). Once the immune system weakens, the body begins to produce minor illnesses which become more severe over time. As HIV progresses into AIDS, manifestations become prolonged and more strenuous causing the individual to suffer or eventually die if left untreated (“Signs”, 2014). The thought of contracting any disease is alarming itself; still, it is crucial to know that any person with the virus can continue living a healthy life without any patent signs (“Signs”, 2014).

HIV, also known as the human immunodeficiency virus, can have diminishing effects on the body’s immune system. Unlike other viruses, such as the flu, the body cannot get rid of HIV. This virus attacks T-cells (T-cells play a huge role in cell immunity), and replicates itself among the attacked T-cells. When too many of the cells have been attacked, and the body can longer fight infection, the HIV infection can then transform into AIDS. (Acquired immune deficiency syndrome)

HIV-II falls under the primate lentivirus group along with: Human immunodeficiency virus (HIV) types 1 and 3, Simian AIDs retrovirus SRV-1, Human T-cell lymphotropoic virus type 4 and Simian immunodeficiency virus (Stanford School of Medicine 2016). The primate lentivirus group uses the CD4 as a receptor and have a conic core which undergoes maturation after budding which allows them to infect the CD4 T lymphocytes (Focosi 2016). Some strains of HIV-II are indistinguishable from SIVsmm which is derived from the sooty mangabeys (AABB.org 2009 102S-104S), and are closely related to the macaque group (Griffin, Allen, Lever 2001). The macaque group is defined as “any number of short-tailed Old World monkeys of the genus Macaca and related genera” chiefly of Asian and African regions; especially rhesus monkey (Webster 1828).

Since the beginning of the epidemic, AIDS has killed more than 30 million people worldwide, including more than 500,000 Americans. AIDS has replaced malaria and tuberculosis as the world's deadliest infectious disease among adults and is the fourth leading cause of death worldwide. Over 13 million children have been orphaned by the epidemic. A person who is HIV-infected carries the virus in certain body fluids, including blood, semen, vaginal secretions, and breast milk. The virus can be transmitted only if such HIV-infected fluids enter the bloodstream of another person. This kind of direct entry can occur (1) through the linings of the vagina, rectum, mouth, and the opening at the tip of the penis; (2) through intravenous injection with a syringe; or (3) through a break in the skin, such as a cut or sore. Usually, HIV is transmitted through:

HIV is global pandemic stands for Human Immunodeficiency Virus, weakens the immune system by destroying the important cells in our body that fights against disease and infection. Our immune system is able to clear out most of the viruses from our body, but once you have HIV , you have it for lifelong. HIV can hide in our body cells for long time and it can attack the T cells and CD4 cells, a key part of our immune system to fight infections and diseases. Overtime, the HIV may attack so many of CD4 cells and our body is no more able to fight against infections. When this happens, HIV can lead to AIDS, the final stage of HIV infection. HIV can be transmitted through sexual contact, injection or drug use, pregnancy, breast feeding, occupational exposure, and rarely through blood transfusion and organ