Bromopropane And Potassium Hydroxide Lab Report

What is the stereochemistry for the bromination of trans-cinnamic acid, and how is it formed?

The makeup of a compound drastically changes its intermolecular forces (IMFs) with the polar silica gel of a TLC plate; this concept is responsible for the variability of Rf values observed throughout the course of lab. The weaker the IMFs, the further a compound will travel through the silica. For instance, ionic interactions are the strongest IMF, but were not present during this experiment. H-bonding IMFs had the greatest impact for our specific compounds. Resorcinol and 3-chlorobenzoic acid exhibited low Rf values, due to its ability to H-Bond to silica’s hydrogen donors and oxygens acceptors (See graph 1). Both were adept to strongly H-bonded to silica because the compounds contained at least 1 H-donor and 2 H-acceptors. Thus, stronger/more

In this experiment, we alkylate sodium saccharin to N-ethylsaccharin with iodoethane in an aprotic solvent N,N dimethylformamide. Nucleophiles in this experiment will react better in an aprotic solvent. Aprotic solvents have dipoles due to its polar bonds but they do not have H atoms that can be donated into a H-bond. The anions which are the O- and N- of sodium saccharin are not solvated therefore are “naked” and the reaction is not inhibited and preceded in an accelerated rate. The reaction was an SN2 reaction. Since the Oxygen and Nitrogen are more electronegative than the carbon on which they’re attached electrons are pulled towards O- and N- attracting the ethane from Iodoethane. Iodine being more electronegative

Introduction: The purpose of this experiment is to understand the kinetics of the hydrolysis of t-butyl chloride.The kinetic order of reaction was studied under the effects of variations in temperature, solvent polarity, and structure. It is particularly observed in tertiarhalides i.e. in SN1mechanism, Nucleophilic Substitution which is in 1storder. It is basically a reaction that involves substitution by a solvent that pretendslikea nucleophile i.e. it donates electrons. The reaction being in firstorder means

(Q:1&2) An unknown (nucleophile) was subjected to SN2 reaction when combined with benzyl bromide (electrophile) in a sodium hydroxide (base) solution. The experiment provided a clear understanding in conducting nucleophilic substitution reaction where heat must be applied in order for the SN2 reaction to move forward. The goal was to determine the unknown by incorporating knowledge of polarity, the laws of physics, and the role of energy when forming crystals; "like dissolves like", "matter cannot be created nor destroyed". (Q3:Techniques) Melting point, recrystallization, and thin layer chromatography (TLC) mediated the ability to find which unknown nucleophile was provided

The SN1 mechanism leads to substitution products, and the E1 mechanism leads to formation of alkenes, therefore in this case, it is shown that this mechanism leads to a substitution of products since the Cl- ion is replacing the OH group by the addition of a strong acid (HCl). When the nucleophile

Table 2: Consists of color extract taken from a red cabbage for a natural indicator. The pH reading that was measured by using the pH meter and the result of the pH reading to determine whether the solution was acidic or basic.

The solvolysis of t-butyl bromide is an SN1 reaction, or a first order nucleophilic substitution reaction. An SN1 reaction involves a nucleophilic attack on an electrophilic substrate. The reaction is SN1 because there is steric obstruction on the electrophile, bromine is a good leaving group due to its large size and low electronegativity, a stable tertiary carbocation is formed, and a weak nucleophile is formed. Since a strong acid, HBr, is formed as a byproduct of this reaction, SN1 dominates over E1. The first step in an SN1 reaction is the formation of a highly reactive carbocation, in which a leaving group is ejected. The ionization to form a carbocation is the rate limiting step of an SN1 reaction, as it is highly endothermic and has a large activation energy. The subsequent nucleophilic attack by solvent and deprotonation is fast and does not contribute to the rate law for the reaction. The Hammond Postulate predicts that the transition state for any process is most similar to the higher energy species, and is more affected by changes to the free energy of the higher energy species. Thus, the reaction rate for the solvolysis of t-butyl bromide is unimolecular and entirely dependent on the initial concentration of t-butyl bromide.

In a bimolecular nucleophilic substitution or SN2 reaction, there is only one-step. This occurs because the addition of the nucleophile and the elimination of the leaving group spontaneously occur at the same time.

When performing the experiment, the objective was to dehydrate the Barium Chloride and to find out the mass difference from when it was hydrated. Throughout the test, it was required to check the measurements of the crucible and cover for the original mass and to be able to see the difference between a hydrated and dehydrated molecule. The Barium Chloride is then placed on top of the Bunsen burner using a ring stand and carefully placing the flames under the crucible. After waiting for about 17 minutes, which would usually allow for the substance to heat up and evaporate all of the water found within it, the crucible had to cool down for about 10 minutes. After it has cooled down, the measurement would be taken again and would be less than

The purpose of this experiment was to determine the pKa of the bromothymol blue (indicator) through absorption spectroscopy. Bromothymol blue being a monoprotic acid base indicator, displays different colors at different pH because of the differences in the ratio of the conjugated acid and base form. The fraction of conjugate acid and base was interpolated for the solutions through the acquired absorbance spectrum of the bromothymol blue at various pH. The rearranged form of Henderson Hasselbalch equation was graphed as a function of pH to determine the pKa of the indicator.

Birinapant (TL32711) is a bivalent SMAC mimetic. Apoptosis resistance acquisition is a fundamental event in the development of cancer. Among the mechanisms is the dysregulation of inhibitor of apoptosis (IAP) proteins regulated by endogenous IAP antagonists such as SMAC. Drugs mimicing the SMAC have been designed to overcome IAP-mediated apoptosis resistance of cancer cells.

Chemical kinetics involving reaction rates and mechanisms is an essential part of our daily life in the modern world. It helps us understand whether particular reactions are favorable and how to save time or prolong time during each reaction. Experiment demonstrated the how concentration, temperature and presence of a catalyst can change the rate of a reaction. 5 runs of dilution and reaction were made to show the effect of concentration on chemical reactions. A certain run from the previous task was twice duplicated to for a “hot and cold” test for reaction rate. The prior run was again duplicated for a test with

An ice bath was prepared in a large beaker and a small cotton ball was obtained. 0.5 g of acetanilide, 0.9 g of NaBr, 3mL of ethanol and 2.5 mL acetic acid was measured and gathered into 50mL beakers. In a fume hood, the measured amounts of acetanilide, NaBr, ethanol and acetic acid were mixed in a 25mL Erlenmeyer flask with a stir bar. The flask was plugged with the cotton ball and placed in an ice bath on top of a stir plate. The stir feature was turned on a medium speed. 7mL of bleach was obtained and was slowly added to the stirring flask in the ice bath. Once all the bleach was added, stirring continued for another 2 minutes and then the flask was removed from the ice bath and left to warm up to room temperature. 0.8mL of saturated sodium thiosulfate solution and 0.5mL of NaOH solution were collected in small beakers. The two solutions were added to the flask at room temperature. The flask was gently stirred. Vacuum filtration was used to remove the crude product. The product was weighed and a melting point was taken. The crude product was placed into a clean 25mL Erlenmeyer flask. A large beaker with 50/50 ethanol/water

The study that focuses on chemical reaction rates is kinetics. Kinetics contributes to the understanding of the speed of chemical reactions and what determines if a reaction happens at all. A large factor in determining if a reaction occurs is if the activation energy can be achieved. Activation energy is the energy required to start a chemical reaction so that it will not need any additional energy to continue. The amount of energy absorbed or transmitted by a solution is proportional to the solution’s molar absorptivity and the concentration of the solute, this is known as Beer’s law.