C4541 Unit 1 Research Paper

Satisfactory Essays
C4541 Description: IC50: 79 nM for EphB3 LDN-211904 is an inhibitor of erythropoietin-producing hepatocellular carcinoma (Eph) receptors. Erythropoietin-producing hepatocellular carcinoma (Eph) receptors, a group of highly conserved transmembrane proteins composed of multiple domains, participate in various cell signaling pathways. So far, 16 Eph receptors have been identified in vertebrates, which can be divided into two major classes (EphA and EphB) based on sequence similarity. Mammals including humans have 14 Eph receptors (EphA1–EphA8, EphA10, EphB1–EphB4 and EphB6). In vitro: Previous study found that LDN-211904, a 4-piperidinyl analog, retained significant EphB3 inhibitory activity, and also had greater aqueous solubility due to
Get Access