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Caffeine Adaptation

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Caffeine is the most widely consumed central-nervous system (CNS) stimulant in the world. It is a commodity that people use to boost their adrenaline and increase their metabolism. Caffeine executes this by increasing the calcium in the brain. While caffeine’s pharmaceutical effects have been studied by many organizations such as the FDA, no studies have been conducted to assess caffeine’s role to induce endurance like adaptations. These adaptations include increased vascularization, mitochondrial biogenesis, and increased oxidative capacity. Specifically, caffeine’s effect on calcium concentrations ([Ca2+]) on the body’s muscular intracellular components and the stimulation of Calcium / calmodulin-dependent kinase (CaMK) has not been studied. It is now known that calcium enhances the calcium-sensitivity of the ADP-ribose-sensitive calcium release channels. This releases intracellular calcium levels in the sarcoplasmic reticulum and the endoplasmic reticulum in cells, specifically neuronal cells. Studies conducted by DeLorenzo, et al., Nehlig et al., and …show more content…

The most efficient way to acquire energy is through high levels of mitochondrial biogenesis and increase in Ca2+ concentrations. Greater concentration of mitochondria and Ca2+ will provide athletes the sustainable energy needed to cause muscle contractions. In addition, continuous exercise induces muscular intracellular and calcium concentrations. These muscle contractions are generated via the transmission of action potentials (AP) through the alpha motor neuron, and once transferred to the muscle fiber increase cytosolic Ca2+. Contractions result in larger levels of intracellular Ca2+, and more activation of CaMKII will efficiently generate these contractions; thereby, reducing the amount of muscle tissue the body damages to produce the energy it needs (Ojuka et al., 2003: Wu et al.,

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