Calcium Channel Blockers Research Paper

1. Calcium channel blockers, a type of anti-hypertensive drug, block the entry of calcium into smooth muscle which causes smooth muscle to relax. Explain how this decreases blood pressure. This dialates arteries and arterioles and slows cardiac conduction. 2. Explain why cutting an arterial vessel will cause a greater loss of blood over the same amount of time than cutting a venous vessel. There is more force expelling blood inan arterial

Calcium plays a very significant role in our bodies. Approximately 99 percent of the calcium in our bodies is stored in the teeth and bones. Calcium generates about two percent of our total body weight. Calcium is crucial in bone formation, keeping strong bones and teeth and is known for helping to prevent osteoporosis. Although calcium is mostly thought about in the bones and teeth, it also plays important roles throughout the body. The amount of calcium outside the bones and teeth may be small in comparison to what is inside the bones and teeth, but is very useful in many functions in the body. Calcium is required in functions such as the contraction

Sarah has been taking prazosin for hypertension which a alpha blocker. It blocks receptors in the arteries in smooth muscle. This helps relax the blood vessels and leads to an increase in blood flow and a lower blood pressure. The most common side effects of are dizziness, drowsiness, fatigue, headache, nervousness, irritability, stuffy or runny nose, nausea, pain in the arms and legs, hypotension, and weakness. Also another side effect is first-dose orthostatic hypotension because initially the patient has more sensitive to the blood pressure-lowering effects. As patients continue to take the medication they become less sensitive and have fewer problems with hypotension. There

Patients who have congestive heart failure and do not respond to diuretics may benefit from a combination of several types of diuretic medication, each with a different system of action. Another medication for someone that has congestive heart failure can take Beta-blockers. Side effects include fatigue, cold hands, headache, upset stomach, constipation, diarrhea, dizziness, and shortness of breath. Data reported from 17 studies, researchers came to the conclusion that the risk of death from all causes was 31 percent lower in patients with heart failure who were treated with beta-blockers than in those not receiving such medications. Aldosterone blockers is a form of medication one may take to help slow down the rate of congestive heart failure.This medication can sometimes affect kidney function and can also increase potassium levels. Aldosterone blockers are prescribed to individuals who develop heart failure after a heart attack. Studies show that these medications can reduce the risk of hospitalization and death from cardiovascular disease. The last form of medication is BiDil (isosorbide

Varying patients may present to their clinician or the emergency department for treatment with heart failure. It is important to understand that there is more than one type of heart failure; primarily the focus is placed on diastolic heart failure and systolic heart failure. Depending upon the cause of heart failure and what areas are affected dictates the treatment plan needed. While there are similarities with both kinds of heart failure, there are also differences that can help the clinician distinguish the diagnosis needed to fit the patient. Once a diagnosis is made the clinician can move forward in determining if the patient is at risk for use of diuretics and then look towards prescribing ACEIs, ARBs, and beta-blockers.

While at the hospital, the patient, was having excessively slow AV nodal conduction rates that unfortunately haven’t been recognized. He started on the prescribed antihypertensive drug (s). As soon as blood levels climb towards the usual therapeutic range the patient goes into complete heart block. Which of the following drugs most likely provoked this further prolongation of the P-R interval, ultimately leading to the complete heart

Nifedipine is a calcium channel blocker which can be used alone or in conjunction with other medications for treatment of angina and hypertension. It decreases the contractility of the arterial smooth muscle as well as the subsequent vasoconstriction through inhibition of calcium ions influx through the L-type calcium channels. As a result, the coronary and systemic arteries become dilated and the delivery of oxygen to the myocardial tissue is increased. Furthermore, the total peripheral resistance is decreased as well as the systemic blood pressure and afterload.

Together ACE inhibitors and ARB’s work to lower heart rate and blood pressure by inhibiting the RAS (renin-angiotensin system) in the sympathetic nervous system. This “fight or flight” system is activated by the heart when it senses the inability of the ventricles to pump blood, in which cardiac output and blood pressure are decreased. These medications act by blocking this system and therefore decreasing blood pressure and heart rate (Markaity, 2012). Commonly used ACE inhibitors include: enalapril (Vasotec), benazepril (Lotensin), lisinopril (Prinivil, Zestril) and captopril (Capoten). Commonly used ARBs include: losartan (Cozaar), Candesartan (Atacand), Valsartan (Diovan) (heart.org).Common side effects of ACE inhibitors and ARBs are: dry cough, dizziness, hypotension and hyperkalemia. Renal function tests and serum potassium levels should be monitored periodically. ACE inhibitors and ARBs have a label of pregnancy category D while in the second and third trimesters

It inhibits Na+K+ ATPase active transport raising cytosolic Na+ concentrtion and leading to the increasement of Ca2+ concentration in the sarcoplasmic reticulum by the reversival exchange of Na+ and Ca2+ in the myocardial cell. This increase in the contraction of the heart (32) and improve cardiac outpur , left ventricualr ejection fraction, stroke volume, pulmonary capilary wedge pressure and exercise tolerance (33). Secondly, digoxin produce vagus activation showing negavite chronotropic action in SA node and negative dromotropic action in AV node. This lead to a shift in automatic balance by dominating the positive iontropic action of the drugs digoxin (33). In this way digoxin is cosinder as a only available inotropic drug which increase cardiac output and decreae pulmoary capillary wedge preure with our increasing heart rate and without decreasing blood pressure

Antihypertensives block nerve impulses that cause arteries to constrict; slow the heart rate, reducing its contractility; restrict the hormone aldosterone in the blood. The primary use of the drug is to reduce and control blood pressure. Lisinopril is a generic form of Zestril, and is a drug that is used to lower blood pressure. It is not catorgorized as a controlled substance.

Angiotensin-converting enzyme inhibitors (ACE inhibitors) open up narrow blood vessels to help improve blood flow.

Beta Blockers are known as a medicine that used to treat a person who has a blood pressure. By blocking the effect of adrenaline and noradrenaline, this drug can lower blood pressure, slow down the heart rate and lessen the force of the blood impelled in the body. While taking this drug, it requires to check the pulse daily and when it is slower than it was supposed to be, ask the doctor if the medication needs to take that day. Sometimes, the beta blocker doesn’t work right while the person is also using another drug. The person who is taking this medication should avoid caffeine and alcohol and for those whom this drug may not work with them are older people and people with asthma, for those who has a low blood pressure, and person who has

No more than 2 percent of hypertensive patients can be treated surgically. There are basically four groups of drugs a physician would prescribe a hypertension patient:DiureticsThis is usually the first choice a doctor would prescribe. It helps by increasing the rate you body eliminates urine and salt. However, this can also increase your cholesterol level, make you urinate more frequently, and may cause a loss of potassium.Beta-Adrenergic BlockersThese drugs are usually prescribed if a diuretic does not help bring your blood pressure down, and sometimes are used in combination with diuretics. Beta-adrenergic blockers work by blocking the effects of adrenaline in your body.

Calcium regulation has significant effects on the human body's capacity to maintain homeostasis. Around 99% of the body's calcium is found within the skeleton in the form of calcium salts. The remaining 1% is found in blood and controlled within a very narrow range

Other side effects include cloudy urine, proteinuria, irregular heartbeats, and chest pain. Angioedema involving the extremities, face, lips, mucous membranes, tongue, glottis or larynx has been seen in patients treated with ACE inhibitors, including captopril (Capoten, 2014). If these effects happen nurses should be ready to administer epinephrine to reduce swelling. Other adverse effect according to Karch (2014) include, “CV: Tachycardia, angina pectoris, heart failure, MI, Raynouds syndrome, hypotension in salt-or volume depleted patients.”