Can Muscle Fatigue Analysis

myasthenia Gravis is caused by a breakdown in the normal communication between nerves and muscles. Muscle weakness which is caused by myasthenia gravis worsens as the affected muscle is used repeatedly.

According to Burgen, M., Stam, H., & Pangailia, R. F 3 doctors who conducted a study and wrote an article “prevalence of pain, fatigue and affective disorders in adults with muscular dystrophy” explain that in addition to the loss of motor functions, in some forms of muscular dystrophy it can affect the heart muscle causing severe heart problems (Burgen). Also, some muscular dystrophy patients suffer from breathing problems as muscles are used to help aid with breathing. Some patients experience a weakness in the swallowing muscle causing it hard to eat and require support to get the proper nutrients. Many patients develop orthopedic problems such as curvatures in the spine or muscle contractions which require surgery to correct. The life of patients with muscular dystrophy is very challenging and simple daily task that people take for granted are very difficult for people that suffer from muscular dystrophy. Patients with muscular dystrophy are constantly in severe pain, experience severe decreased mobility, and have overall weak muscle function.

Fatigue in athletes may be thought of as presenting on a continuum: More transient states that last hours or days (as in overreaching) to chronic states that may take months of rest or reduced activity, as well as other interventions, to resolve (Derman et al., 2000). Moreover, repeated, exhaustive, successive exercise may increase the risk of chronic immunodepression (Castell, 2003). Along this continuum, Budgett (2000) recognizes a fatigue state termed Unexplained Underperformance Syndrome (UPS), defined as "persistent performance deficit despite 6 weeks relative rest". This time frame differentiates UPS from Chronic Fatigue Syndrome (CFS), a hallmark of which is symptoms lasting at least 8 months. As in UPS, Overtraining Syndrome

The causes of fatigue during exercise could be any combination. Some happen within the muscle itself, like the decreased rate of energy production ATP, anaerobic glycolysis, and aerobic metabolism. The accumulation of metabolic lactate and H+. The failure of the muscle fiber's contractile mechanism from a injury of some sort. Also alterations in neural control of muscle contraction such as changes in the brain or central nervous system. It all depends on the type and intensity of the exercise, the fiber type of the involved muscles, and even the nutritional diet. (Kenney, 11/2011, p. 128)

5. What could be a chemical cause of fatigue? It is suspected that fatigue is caused by an accumulation of lactic acid, ADP, and P, in muscles. Another reason comes from Calcium levels decreasing from muscle contractions.

It’s not a surprise no one is getting any younger and that we are all aging. Once we dip into our thirties muscle strength can decrease by 3-5 percent every decade and 10-20 percent each decade once we hit sixty. With all of this muscle loss, how can “older” adults compete in triathlons or weight-lifting competitions?

PCr depletion, ATP decreasing, muscle glycogen depletion, possibly lactic acid accummulation --> increased muscle acidosis (increased H+), Failure of muscle fiber's contractile mechanism 2) glycogen depletion, increased muscle temperature, loss of water (dehydration) and electrolytes (high body T)

Loss of skeletal muscle with advancing age begins relatively early, and continues until the end of life. From 20 to 80 years of age, there is a ≈30% reduction in muscle mass and a decline in cross-sectional area of ≈20%. This is due to a decline in both muscle fiber size and number (Evans, 2010).

Another common cause for muscle pain and dysfunction is repetitive movements. For example, a person who types each day at work can suffer wrist pain and stiffness. If the person does not address this problem, it can lead to carpal tunnel syndrome, which is debilitating at times.

As women age, muscle control begins to slowly decline. The choice in loss of muscular velocity seems to be voluntary due to the lack of strength training in older women. In order for muscles to strengthen, activation through endurance is necessary. The study done by Andre Gurjao, and his colleagues, suggest the use of strength training (ST) has a positive correlation on rate force development in women, specifically older women. Neuromuscular changes take affect on the power contributed within muscles that are accompanied with aging. Strength training reverses the effects of muscular power deterioration by improving neuromuscular performance in older adults (Gurjão, Gobbi,Carneiro et al., 2012).

The human body is not invincible. None of us are Captain America, and our muscles will break down when lifting weights. If a human’s muscles do not get the time it needs to recover, then muscles will stay broken down and torn, thus leaving no time for the muscles to rebuild as a stronger muscle. The important part of the lifting process is the regeneration of the muscle, as the goal is for those muscles to become stronger and healthier, and if not given a proper resting period, ruins the whole purpose of the lifting process.

Stay away from overtraining: If you feel weak, or aching, you are likely overtraining. This article explains just how to avoid the common mistake of overtraining. Hypothetically then, you might do your chest muscles, shoulders, triceps and ab muscles on Friday; on Sunday you might do your legs, back, biceps and ab muscles; you would take Wednesday off to provide your muscle tissues some time off; on Thursday you'd do chest, back, triceps as well as ab muscles once more; and on Sunday you would probably do legs, back, biceps and abdominals again. Muscle tissues grow by tearing, as well as mending. Therefore, the time off is

cramping and fatigue. Potassium builds up in the t-tubule system and around the muscle fiber as a

1. In terms of progressive weakness and degeneration of muscles one group of disorders is being connected from it and that disorder is called Muscular Dystrophy. It is said to be caused by mutations on the X chromosome and due to not being able to produce a protein called Dystrophin that plays a vital role in building and repairing muscles that cannot function properly. The said protein aids various elements within muscle cells together and bonds them all to the outer membrane or the sarcolemma. Without the presence of dystrophin, disruptions transpire in the sarcolemma results to weakening of muscles and may cause damage to the muscle cells.

Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder that is characterized by fatigue and exhaustion of muscle. The skeletal muscles is having different degrees of weakness and this occurs when nerve cells and muscle are not be able to communicate efficiently and becomes impaired. This impairment put a stop to the muscle contraction from occurring which can lead to muscle weakness. Myasthenia Gravis originally comes from the Latin and Greek words that means “grave muscle weakness’’. According to Osserman (as cited in Turner, 2007) MG is divided into four groups based on the severity of the disease - ocular myasthenia, generalised myasthenia of mild or moderate severity, severe generalised myasthenia, and myasthenic crisis with respiratory failure. The history of MG dated