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Canagliflozin Research Paper

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Canagliflozin is an oral selective Sodium-Glucose co-transporter 2 (SGLT2) inhibitor used for the management of type 2 Diabetes Mellitus [1]. The chemical name (IUPAC) of Canagliflozin is (2S,3R,4R,5S,6R)-2-{3-[5-(4-fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyltetrahydro-pyran-3,4,5-triol with molecular formula C24H25FO5S. It is white to off white solid with melting point of 95-105ºC . It is soluble in many organic solvents (methanol, Dimethyl sulfoxide) but insoluble in aqueous media.It curbs the transporter protein SGLT2 present in the proximal tubules of the kidney which curtails renal glucose absorption, thereby increasing urinary glucose excretion and lowering blood glucose levels. It is a product of Mitsubishi
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