Cancer Associated Cachexia (CAC): A Case Study

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Cancer-associated cachexia (CAC) is a paraneoplastic syndrome characterized by 1. systemic inflammation, 2. body weight loss, 3. atrophy of adipose tissue, and 4. skeletal muscle wasting. CAC is observed in a majority of cancer patients with advanced disease.

In addition to cancer patients, cachexia is typically seen at the end stage of various other morbidities, including infectious diseases, such as AIDS and tuberculosis, or chronic conditions, such as congestive heart failure, chronic obstructive lung disease, and multiple sclerosis.

No effective treatment is currently available for cachexia, which is responsible for approximately 20% of total deaths in cancer patients. Therefore, new therapeutic targets for cachexia prevention and treatment
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