Cancer Essay

A team from the Brazilian university says the experimental drug binds with tumor cells and causes the loss of key molecules.

Compound 3a was selected by the National Cancer Institute (NCI) USA for anticancer screening with the NCI code D-785902/1. Compound 3c was found in the already tested cancer candidates in the NCI data base under NCI code NSC: 650353[42]. Both candidates were screened on human tumour cell lines at 10-5 M at the 60-Cell-Line Screenings of the Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI, Bethesda, Maryland, USA) under the drug discovery program of the NCI. The 60-cell-line-screening of the NCI includes 60 different tumour cell lines, the nine various organs and tumour types derived (leukaemia, non-small-cell lung cancer, colon cancer, CNS cancer, melanoma,

Sitting across from the doctor’s desk, listening to him say the last three words no one ever imagined. You have cancer. The hard plastic chair and the atmosphere in the room suddenly feel colder as your body and mind go still. The doctor rambles on about the state of the condition, but nothing is absorbed. There is only one thing that needs answering. Is this curable? Cancer is a truly devastating verdict to be given and something no one is ready for. Every city, state, country, and continent in the world experiences great loss due to deaths from cancer. It does not discriminate between men and women, young or old, black or white. Dying from cancer is not how anyone would want

TP53, also called tumor protein 53 is a tumor suppressor gene that encodes p53 and acts as a control center for the cell to act on when stressed (Brachova). Human p53 is a nuclear phsophoprotein of molecular weight 53kDa located on chromosome 17 containing 11 exons and 10 introns (Ling). One of its primary roles is as a transcription factor and in its active state is a homotetramer comprised of four 393 amino acid residues (Joerger , The tumor suppressor p53). Another main role p53 plays is as a tumor suppressor and once activated, protects against cancer by “functioning as a sequence-specific transcription factor, through protein-protein interactions, activating cell cycle arrest, apoptosis, and DNA damage repair (Brachova).”

Cancer kills many people a year, but with a single prescription drug, it can stop it. This drug is call pembrolizumab and it was marketed by Merck as Keytruda. This prescription drug can help all kinds of cancers, not just one or two. Immunotherapy drug opens a new era of precision medicine for cancer, many people think of this as a cancer breakthrough. I believe this new drug will help patients who are diagnosed with cancer.

This review will provide a brief investigation of current cancer therapies and the lack of effectiveness that these treatments provide while treating the disease. The aim of this review is to discuss the urgent need to develop new and effective cancer therapy options that can bridge the gap between the various types of cancer and effective cancer targeting.

After finding the target of disease, it gets much easier to find out the specific drug that will target the disease. Dr. Burdette’s lab screened many compounds and found 4 compounds that has already been approved by FDA that could potential

The drug will have severe side effects as mentioned above. Overdosing will lead to extreme health conditions and the cancer may develop resistance to the medicine.

More than four thousands mutations of p53 genes have been identified in human tumors. p53 mutation in human skin cancers is consider to be unique mutation among other cancers mutations. p53 mutation in human skin cancers is mostly found to be C to T transitions. These transitions are located on dipyrimidine sites that are the specific target for UV radiation (Dumaz et. al, 1997). Alteration of tumor suppressor gene p53 will hinder p53 to repair damaged DNA or perform apoptosis as needed, which then results in precancerous cell (Madan et. al,

In the recent decade, neoplasms are incurably deleterious, formidable non-communicable diseases. A neoplasm presumably arises when a singly normal cell in a given tissue has dynamically accumulated irreversible genetic impairments and instability of such key genes. And these preposterous genes usually incurs a perversity of cell cycle, growth, proliferation, differentiation, survival as well as senescence because they have lost their regulatory functions (Hanahan and Weinberg, 2000; Kumar et al., 2013; Strayer and Rubin, 2014).

These agents are therapeutically useful as they are specific against the receptor they are formulated against and have a long half-life which means that they can be used in chronic conditions and disease relapse

If given before surgery, then it is meant to shrink the size of the cancer, and if given after surgery, then it is to kill the cancer cells remaining behind after surgery, and may re-grow in the patient's body. To be given before surgery or after surgery or along with radiation therapy depends on the condition of the patient, the extent to which the cells have spread in his / her body and his / her

There are basically two important components present in the cancer that are the defense against the immune attack is (1) Myeloid derived suppressor cells and (2) Regulatory T cells. When these two cells are present, it affects the health of the person suffering from cancer. They mainly suppress the activity of immune system towards Cancerous cells. In a very short course of the drug, when given regularly to the patients will help to decrease these two types of cells from place where the tumor is present in the body. This drug will also increase the percentage of the tumor specific CD8+T cell in circulation of the cancer patient blood. It will also promote the activation on CD8+T cell in the tumor site. This drug could also help to reduce the tumor’s ability for defending itself from the immune system of patient. And for the best results the drug is also combined with the tumor vaccines which will cause more potent immune response to the body. The next effect is that it can produce is that it will reduce recurrent rates of cancer in the

It also can be used with other drugs and radiotherapy to destroys cancer cells and prevents them from coming back. In the article Breast Cancer Risk as Disease by Jennifer Ruth Fosket:

Patients suffer from poor quality of life while in treatment and even after the treatment has finished. Therefore, there is a need to develop new cancer therapeutics that are efficient, by minimizing toxicity and increase the local effective effect of chemotherapy drugs, at reasonable cost and provide patients with a high quality of life.